Genomic Location: sc0000256_pilon:276146...306793
NR annotation: XP_044162892.1, C-myc promoter-binding protein-like [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0256.g16.t1 |
| Transcript |
| amur_s0256.g16.t1 |
| Protein |
| amur_s0256.g16.t1 |
| UniProt accession | Description |
|---|---|
| Q7Z401 | C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2 |
| A6H8H2 | DENN domain-containing protein 4C OS=Mus musculus OX=10090 GN=Dennd4c PE=1 SV=1 |
| Q5VZ89 | DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003075 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF03456 all species → | uDENN | uDENN domain | Domain | Interproscan |
| PF03455 all species → | dDENN | dDENN domain | Domain | Interproscan |
| PF02141 all species → | DENN | DENN (AEX-3) domain | Family | Interproscan |
| PF13041 all species → | PPR_2 | PPR repeat family | Repeat | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR043153 all species → | Homologous_superfamily | DENN domain, C-terminal lobe | Interproscan |
| IPR005113 all species → | Domain | uDENN domain | Interproscan |
| IPR002885 all species → | Repeat | Pentatricopeptide repeat | Interproscan |
| IPR005112 all species → | Domain | dDENN domain | Interproscan |
| IPR011990 all species → | Homologous_superfamily | Tetratricopeptide-like helical domain superfamily | Interproscan |
| IPR051696 all species → | Family | DENN Domain-Containing GEFs | Interproscan |
| IPR023341 all species → | Domain | MABP domain | Interproscan |
| IPR001194 all species → | Domain | cDENN domain | Interproscan |
| IPR037516 all species → | Domain | Tripartite DENN domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR12296 all species → | DENN DOMAIN-CONTAINING PROTEIN 4 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0031410 all species → | Cellular Component | cytoplasmic vesicle | Interproscan |
| GO:0032483 all species → | Biological Process | regulation of Rab protein signal transduction | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K20163 | DENND4; DENN domain-containing protein 4 | - | Membrane trafficking | ko04131 | deepkoala |
Transcript abundance of amur_s0256.g16.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 71 | 19.85 | 76.99 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 76.99 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 72.39 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 49.07 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 47.42 |
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 45.30 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 38.48 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 36.90 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 36.35 |
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 35.23 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 34.53 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 33.86 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 33.57 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 32.76 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 31.93 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 29.96 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 29.87 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 28.90 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 27.76 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 27.31 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 26.37 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 26.06 |
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 25.75 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 25.74 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 24.57 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 24.39 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 24.09 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 23.25 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 22.92 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 22.56 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 22.48 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 22.33 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 22.13 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 21.82 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 21.37 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 21.31 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 19.19 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 18.43 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 18.35 |
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 17.83 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 17.48 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 17.46 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 16.87 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 16.85 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 16.71 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 16.55 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 14.91 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 14.89 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 13.65 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 13.40 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 13.01 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 12.96 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 12.30 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 12.16 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 12.12 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 11.70 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 11.47 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 10.04 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 9.97 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 9.89 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 9.61 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 9.00 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 8.84 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 8.71 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 8.69 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 7.84 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 7.82 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 7.64 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 6.94 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 6.48 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 6.47 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 6.46 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 26 | amur_s0641.g1.t1 | 0.839358686073174 |
| Negatively correlated | 5 | amur_s0472.g7.t1 | -0.276139541901025 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |