Genomic Location: sc0000257_pilon:263386...291125
NR annotation: XP_029214230.2, proto-oncogene vav-like isoform X1 [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0257.g11.t1 |
| Transcript |
| amur_s0257.g11.t1 |
| Protein |
| amur_s0257.g11.t1 |
| UniProt accession | Description |
|---|---|
| P54100 | Proto-oncogene vav OS=Rattus norvegicus OX=10116 GN=Vav1 PE=2 SV=1 |
| P15498 | Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4 |
| Q08DN7 | Proto-oncogene vav OS=Bos taurus OX=9913 GN=VAV1 PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002902 (this species only) · gene tree & orthology |
| Ubiquitin family | UBD|Other|SH3 · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00307 all species → | CH | Calponin homology (CH) domain | Domain | Interproscan |
| PF00018 all species → | SH3_1 | SH3 domain | Domain | Interproscan |
| PF00169 all species → | PH | PH domain | Domain | Interproscan |
| PF00621 all species → | RhoGEF | RhoGEF domain | Domain | Interproscan |
| PF00130 all species → | C1_1 | Phorbol esters/diacylglycerol binding domain (C1 domain) | Domain | Interproscan |
| PF00017 all species → | SH2 | SH2 domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR036028 all species → | Homologous_superfamily | SH3-like domain superfamily | Interproscan |
| IPR035899 all species → | Homologous_superfamily | Dbl homology (DH) domain superfamily | Interproscan |
| IPR001331 all species → | Conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Interproscan |
| IPR011993 all species → | Homologous_superfamily | PH-like domain superfamily | Interproscan |
| IPR036872 all species → | Homologous_superfamily | CH domain superfamily | Interproscan |
| IPR000219 all species → | Domain | Dbl homology (DH) domain | Interproscan |
| IPR036860 all species → | Homologous_superfamily | SH2 domain superfamily | Interproscan |
| IPR001715 all species → | Domain | Calponin homology domain | Interproscan |
| IPR002219 all species → | Domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Interproscan |
| IPR001452 all species → | Domain | SH3 domain | Interproscan |
| IPR033116 all species → | Active_site | Serine proteases, trypsin family, serine active site | Interproscan |
| IPR000980 all species → | Domain | SH2 domain | Interproscan |
| IPR001849 all species → | Domain | Pleckstrin homology domain | Interproscan |
| IPR009003 all species → | Homologous_superfamily | Peptidase S1, PA clan | Interproscan |
| IPR043504 all species → | Homologous_superfamily | Peptidase S1, PA clan, chymotrypsin-like fold | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45818 all species → | PROTEIN VAV | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0005085 all species → | Molecular Function | guanyl-nucleotide exchange factor activity | Interproscan |
| GO:0035556 all species → | Biological Process | intracellular signal transduction | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0016477 all species → | Biological Process | cell migration | Interproscan |
| GO:0043087 all species → | Biological Process | regulation of GTPase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K05730 | VAV; guanine nucleotide exchange factor VAV | - | Lipid and atherosclerosis | ko05417 | deepkoala |
Transcript abundance of amur_s0257.g11.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 68 | 29.52 | 76.37 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 76.37 |
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 60.40 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 60.27 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 52.32 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 48.85 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 47.46 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 46.95 |
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 45.44 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 45.23 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 44.02 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 42.25 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 41.32 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 40.59 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 39.75 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 39.75 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 38.95 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 38.90 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 38.81 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 38.76 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 38.24 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 37.71 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 37.59 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 36.80 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 35.46 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 35.37 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 35.17 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 34.72 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 34.65 |
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 34.54 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 33.73 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 33.45 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 33.35 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 33.20 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 33.05 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 32.88 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 31.71 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 31.65 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 31.44 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 30.98 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 30.97 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 30.83 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 30.30 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 30.06 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 30.04 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 29.76 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 29.51 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 29.26 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 29.21 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 28.79 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 28.65 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 28.35 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 28.19 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 27.17 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 26.27 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 26.00 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 25.67 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 25.60 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 24.20 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 23.82 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 23.74 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 23.74 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 23.00 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 21.94 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 21.88 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 21.79 |
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 21.75 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 20.38 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 19.24 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 0.00 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 0.00 |
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 14 | amur_s0131.g3.t1 | 0.765221939244319 |
| Negatively correlated | 6 | amur_s0022.g29.t1 | -0.337608125571143 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |