Genomic Location: sc0000388_pilon:1...24345
NR annotation: XP_029182717.2, histone lysine acetyltransferase CREBBP-like isoform X1 [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0388.g1.t1 |
| Transcript |
| amur_s0388.g1.t1 |
| Protein |
| amur_s0388.g1.t1 |
| UniProt accession | Description |
|---|---|
| Q92793 | CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3 |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP OS=Rattus norvegicus OX=10116 GN=Crebbp PE=1 SV=1 |
| B2RWS6 | Histone acetyltransferase p300 OS=Mus musculus OX=10090 GN=Ep300 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001731 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00569 all species → | ZZ | Zinc finger, ZZ type | Domain | Interproscan |
| PF02172 all species → | KIX | KIX domain | Domain | Interproscan |
| PF06001 all species → | RING_CBP-p300 | CREB-binding protein/p300, atypical RING domain | Domain | Interproscan |
| PF02135 all species → | zf-TAZ | TAZ zinc finger | Family | Interproscan |
| PF08214 all species → | HAT_KAT11 | Histone acetylation protein | Domain | Interproscan |
| PF00439 all species → | Bromodomain | Bromodomain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000433 all species → | Domain | Zinc finger, ZZ-type | Interproscan |
| IPR036529 all species → | Homologous_superfamily | Coactivator CBP, KIX domain superfamily | Interproscan |
| IPR000197 all species → | Domain | Zinc finger, TAZ-type | Interproscan |
| IPR003101 all species → | Domain | Coactivator CBP, KIX domain | Interproscan |
| IPR013178 all species → | Family | Histone acetyltransferase Rtt109/CBP | Interproscan |
| IPR010303 all species → | Domain | CREB-binding protein/p300, atypical RING domain | Interproscan |
| IPR031162 all species → | Domain | CBP/p300-type histone acetyltransferase domain | Interproscan |
| IPR001487 all species → | Domain | Bromodomain | Interproscan |
| IPR038547 all species → | Homologous_superfamily | CBP/p300, atypical RING domain superfamily | Interproscan |
| IPR035898 all species → | Homologous_superfamily | TAZ domain superfamily | Interproscan |
| IPR036427 all species → | Homologous_superfamily | Bromodomain-like superfamily | Interproscan |
| IPR018359 all species → | Conserved_site | Bromodomain, conserved site | Interproscan |
| IPR043145 all species → | Homologous_superfamily | Zinc finger, ZZ-type superfamily | Interproscan |
| IPR013083 all species → | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR13808 all species → | CBP/P300-RELATED | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0003712 all species → | Molecular Function | transcription coregulator activity | Interproscan |
| GO:0006355 all species → | Biological Process | regulation of DNA-templated transcription | Interproscan |
| GO:0004402 all species → | Molecular Function | histone acetyltransferase activity | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0000123 all species → | Cellular Component | histone acetyltransferase complex | Interproscan |
| GO:0003713 all species → | Molecular Function | transcription coactivator activity | Interproscan |
| GO:0005667 all species → | Cellular Component | transcription regulator complex | Interproscan |
| GO:0016573 all species → | Biological Process | obsolete histone acetylation | Interproscan |
| GO:0031490 all species → | Molecular Function | chromatin DNA binding | Interproscan |
| GO:0045944 all species → | Biological Process | positive regulation of transcription by RNA polymerase II | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K04498 | EP300, CREBBP, KAT3; E1A/CREB-binding protein | EC:2.3.1.48 | Mitochondrial biogenesis | ko03029 | deepkoala |
Transcript abundance of amur_s0388.g1.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 70 | 28.62 | 101.33 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 101.33 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 71.70 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 59.91 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 57.91 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 52.83 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 49.49 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 48.25 |
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 48.09 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 47.90 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 47.57 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 46.39 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 46.16 |
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 43.64 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 41.67 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 40.61 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 40.25 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 40.01 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 39.80 |
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 39.73 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 39.39 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 39.17 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 39.05 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 38.90 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 38.32 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 37.66 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 36.17 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 35.66 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 35.51 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 34.78 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 34.70 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 34.60 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 33.98 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 33.33 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 28.79 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 28.71 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 28.39 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 28.27 |
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 27.73 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 27.41 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 26.90 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 26.70 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 26.20 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 25.84 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 25.58 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 25.33 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 25.11 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 24.87 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 24.83 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 24.17 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 23.72 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 23.71 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 23.35 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 21.60 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 21.50 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 21.28 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 21.10 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 20.78 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 20.39 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 19.96 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 19.57 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 18.94 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 15.77 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 13.26 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 12.54 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 12.54 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 12.51 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 11.13 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 10.82 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 10.27 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 7.35 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 0.00 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 18 | amur_s0543.g5.t1 | 0.792484529895575 |
| Negatively correlated | 13 | amur_s0207.g9.t1 | -0.337928355663156 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |