Detailed information of amur_s0419.g18.t1 in Acropora muricata

Genomic Location: sc0000419_pilon:271786...276945
NR annotation: XP_029189259.2, malate dehydrogenase, cytoplasmic-like [Acropora millepora]
Species Acropora muricata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q5ZME2Malate dehydrogenase, cytoplasmic OS=Gallus gallus OX=9031 GN=MDH1 PE=2 SV=1
Q3T145Malate dehydrogenase, cytoplasmic OS=Bos taurus OX=9913 GN=MDH1 PE=2 SV=3
P11708Malate dehydrogenase, cytoplasmic OS=Sus scrofa OX=9823 GN=MDH1 PE=1 SV=4
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0004850 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF02866
all species →
Ldh_1_Clactate/malate dehydrogenase, alpha/beta C-terminal domainDomainInterproscan
PF00056
all species →
Ldh_1_Nlactate/malate dehydrogenase, NAD binding domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR010945
all species →
FamilyMalate dehydrogenase, type 2Interproscan
IPR011274
all species →
FamilyMalate dehydrogenase, NAD-dependent, cytosolicInterproscan
IPR015955
all species →
Homologous_superfamilyLactate dehydrogenase/glycoside hydrolase, family 4, C-terminalInterproscan
IPR022383
all species →
DomainLactate/malate dehydrogenase, C-terminalInterproscan
IPR001236
all species →
DomainLactate/malate dehydrogenase, N-terminalInterproscan
IPR001557
all species →
FamilyL-lactate/malate dehydrogenaseInterproscan
IPR036291
all species →
Homologous_superfamilyNAD(P)-binding domain superfamilyInterproscan
IPR001252
all species →
Active_siteMalate dehydrogenase, active siteInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR23382
all species →
MALATE DEHYDROGENASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006108
all species →
Biological Processmalate metabolic processInterproscan
GO:0016615
all species →
Molecular Functionmalate dehydrogenase activityInterproscan
GO:0030060
all species →
Molecular FunctionL-malate dehydrogenase (NAD+) activityInterproscan
GO:0003824
all species →
Molecular Functioncatalytic activityInterproscan
GO:0016616
all species →
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorInterproscan
GO:0005739
all species →
Cellular ComponentmitochondrionInterproscan
GO:0005829
all species →
Cellular ComponentcytosolInterproscan
GO:0006099
all species →
Biological Processtricarboxylic acid cycleInterproscan
GO:0006107
all species →
Biological Processoxaloacetate metabolic processInterproscan
GO:0006734
all species →
Biological ProcessNADH metabolic processInterproscan
GO:0016491
all species →
Molecular Functionoxidoreductase activityInterproscan
GO:0019752
all species →
Biological Processcarboxylic acid metabolic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K00025MDH1; malate dehydrogenaseEC:1.1.1.37
Proximal tubule bicarbonate reclamationko04964deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of amur_s0419.g18.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

82Samples
73TPM > 0
2Conditions
954.1Max TPM
445.8Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Polyps 79 73 462.73 954.08
Severed branch 3 0 0.00 0.00

Per sample · hover a bar for the full sample record

Show the sample table (82 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR12710849 Polyps Polyps OA 2 day3 not recorded SRP199550 954.08
SRR12710850 Polyps Polyps OA 2 day3 not recorded SRP199550 948.85
SRR12710851 Polyps Polyps OA 2 day3 not recorded SRP199550 947.21
SRR12710860 Polyps Polyps OA 2 day9 not recorded SRP199550 891.44
SRR12710861 Polyps Polyps OA 2 day9 not recorded SRP199550 871.81
SRR12710859 Polyps Polyps OA 2 day9 not recorded SRP199550 870.66
SRR27868160 Polyps Polyps regeneration day6 not recorded SRP199550 744.73
SRR27940222 Polyps Polyps not recorded not recorded SRP199550 666.15
SRR27868195 Polyps Polyps regeneration day21 not recorded SRP199550 656.69
SRR27940225 Polyps Polyps not recorded not recorded SRP199550 647.68
SRR27940227 Polyps Polyps not recorded not recorded SRP199550 625.77
SRR12959232 Polyps Polyps E2 day3 not recorded SRP199550 618.07
SRR27868159 Polyps Polyps regeneration day6 not recorded SRP199550 611.58
SRR27868196 Polyps Polyps regeneration day21 not recorded SRP199550 592.95
SRR12959206 Polyps Polyps E2 day0 not recorded SRP199550 587.71
SRR27868198 Polyps Polyps regeneration day0 not recorded SRP199550 563.96
SRR27868158 Polyps Polyps regeneration day6 not recorded SRP199550 562.46
SRR12959191 Polyps polyps E2 day21 not recorded SRP199550 555.25
SRR27940226 Polyps Polyps not recorded not recorded SRP199550 548.58
SRR12959195 Polyps Polyps E2 day0 not recorded SRP199550 543.67
SRR12959193 Polyps Polyps E2 day21 not recorded SRP199550 542.49
SRR27868206 Polyps Polyps regeneration day12 not recorded SRP199550 536.08
SRR12959192 Polyps Polyps E2 day21 not recorded SRP199550 524.77
SRR27868192 Polyps Polyps regeneration day24 not recorded SRP199550 507.87
SRR12786900 Polyps Polyps OA 2 day0 not recorded SRP199550 507.74
SRR27868175 Polyps Polyps regeneration day39 not recorded SRP199550 506.03
SRR27868210 Polyps Polyps regeneration day0 not recorded SRP199550 504.57
SRR27940228 Polyps Polyps not recorded not recorded SRP199550 504.39
SRR12959231 Polyps Polyps E2 day3 not recorded SRP199550 504.18
SRR27868194 Polyps Polyps regeneration day21 not recorded SRP199550 502.01
SRR12904786 Polyps Polyps not recorded not recorded SRP199550 501.98
SRR12959233 Polyps Polyps E2 day3 not recorded SRP199550 496.87
SRR12959217 Polyps Polyps E2 day0 not recorded SRP199550 494.38
SRR27868183 Polyps Polyps regeneration day33 not recorded SRP199550 484.70
SRR27868185 Polyps Polyps regeneration day30 not recorded SRP199550 483.53
SRR12786899 Polyps Polyps OA 2 day0 not recorded SRP199550 479.96
SRR27868193 Polyps Polyps regeneration day24 not recorded SRP199550 478.14
SRR12786901 Polyps Polyps OA 2 day0 not recorded SRP199550 473.07
SRR27868197 Polyps Polyps regeneration day18 not recorded SRP199550 470.22
SRR27868201 Polyps Polyps regeneration day15 not recorded SRP199550 467.95
SRR27868186 Polyps Polyps regeneration day30 not recorded SRP199550 466.52
SRR27940224 Polyps Polyps not recorded not recorded SRP199550 465.09
SRR27868200 Polyps Polyps regeneration day18 not recorded SRP199550 463.68
SRR12904784 Polyps Polyps not recorded not recorded SRP199550 463.24
SRR27868208 Polyps Polyps regeneration day9 not recorded SRP199550 453.45
SRR27868179 Polyps Polyps regeneration day36 not recorded SRP199550 450.27
SRR27868207 Polyps Polyps regeneration day9 not recorded SRP199550 450.08
SRR27868184 Polyps Polyps regeneration day30 not recorded SRP199550 426.01
SRR27868199 Polyps Polyps regeneration day18 not recorded SRP199550 425.49
SRR12959219 Polyps Polyps E2 day9 not recorded SRP199550 425.25
SRR27868204 Polyps Polyps regeneration day12 not recorded SRP199550 421.11
SRR12959220 Polyps Polyps E2 day9 not recorded SRP199550 419.31
SRR27868180 Polyps Polyps regeneration day36 not recorded SRP199550 412.85
SRR27868176 Polyps Polyps regeneration day3 not recorded SRP199550 409.32
SRR12959218 Polyps Polyps E2 day9 not recorded SRP199550 401.80
SRR27868202 Polyps Polyps regeneration day15 not recorded SRP199550 401.37
SRR27868174 Polyps Polyps regeneration day39 not recorded SRP199550 398.87
SRR27868178 Polyps Polyps regeneration day36 not recorded SRP199550 394.19
SRR27868182 Polyps Polyps regeneration day33 not recorded SRP199550 393.19
SRR12959204 Polyps Polyps E2 day15 not recorded SRP199550 390.28
SRR12959205 Polyps Polyps E2 day15 not recorded SRP199550 385.74
SRR27868203 Polyps Polyps regeneration day15 not recorded SRP199550 378.36
SRR27868187 Polyps Polyps regeneration day3 not recorded SRP199550 377.39
SRR27868189 Polyps Polyps regeneration day27 not recorded SRP199550 373.84
SRR27868209 Polyps Polyps regeneration day0 not recorded SRP199550 359.78
SRR12904785 Polyps Polyps not recorded not recorded SRP199550 351.78
SRR27868188 Polyps Polyps regeneration day27 not recorded SRP199550 338.71
SRR27868177 Polyps Polyps regeneration day39 not recorded SRP199550 303.51
SRR27868205 Polyps Polyps regeneration day12 not recorded SRP199550 301.81
SRR12959207 Polyps Polyps E2 day15 not recorded SRP199550 227.70
SRR27868165 Polyps Polyps regeneration day3 not recorded SRP199550 225.68
SRR27868181 Polyps Polyps regeneration day33 not recorded SRP199550 218.97
SRR27868190 Polyps Polyps regeneration day27 not recorded SRP199550 200.62
SRR12807382 Polyps Polyps OA2 day0 not recorded SRP199550 0.00
SRR12927881 Polyps Polyps E2 day0 not recorded SRP199550 0.00
SRR27868191 Polyps Polyps regeneration day24 not recorded SRP199550 0.00
SRR27940229 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9613488 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9613516 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR12995717 Severed branch Severed branch regeneration day0 not recorded SRP199550 0.00
SRR12996627 Severed branch Severed branch regeneration day0 not recorded SRP199550 0.00
SRR12996628 Severed branch Severed branch regeneration High gene expression not recorded SRP199550 0.00

Source: CnidoSite RNA-seq expression matrices (AMURI_TPM, StringTie quantification over 82 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated46amur_s0106.g59.t10.904696202761063
Negatively correlated5amur_s0022.g29.t1-0.394900135317118

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

DatasetTissue / stageCellsCell typesThis geneMarker of
AMURI_regenPolyps · regeneration8,72128unmapped

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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