Gene detail

Detailed information of asel_s0008.g50.t1 in Acropora selago

Genomic Location: sc0000008_pilon:636135...658762
NR annotation: XP_029196361.2, insulin-degrading enzyme-like [Acropora millepora]
Species Acropora selago · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

asel_s0008.g50.t1

ATGCCAATGGAGGGAGTAAAGAAAATTTTCAACGAAATTCCCAAATCGCCCCGCGATGACAGGCAGTATCGGGGTTTACAACTGAAAAATGAAATGAAAGTTTTGGTTATTAGTGACCCCAGCACAGACAAATCAGCAGCCGCGATGGATGTACACATTGGTAATTTGAGTGACCCAGATGATTTCCCAGGTCTTGCGCATTTTTGTGAACACATGTTATTTCTTGGAACTGAAAAGTATCCATCAGAGAATTCGTTCACTCAGTTTTTAAGTGAAAATGGTGGATCATCTAATGCATTCACAGGAGGTGAACACACCAACTTTTTCTTTGATATCAAACATGAATGTTTGAATGAAGCTTTAGATAGATTTGGACAGTTCTTCCTTTGTCCGTTATTCAATTCAGATGCAACAGATAGGGAAGTCAATGCCGTTGAATCAGAACATCTGAAGAATATCTTAAATGATTCTTGGAGGTTAAATCAACTTGATAAGTCTACGGTGGATCCATCGCACCCATTCAGTAGATTTGGAACAGGTAACAAACTGACGCTTGACACGCGACCAAAGGAAAAAGGGCTCAGTATACGAGATGAGCTTCTTAAATTTCACAGCTCCTTCTACTCGGCCAATATCATGGCACTTGTGGTTCTTGGCAGAGAATCCCTTGATGATCTGACAAATCTCACCATAAAGCTCTTCTCAGATGCTGAAGATAAATGCATTGCAATTCCTGAGTTCCCTGTGCATCCATATGGCGATAAACAGTTACAGGTAGAATTCAAAGTGGTGCCTGTGAAAGACATAAAACACCTGAACATTTCATTTCCAATACCAGATGTTTCACAACATTATGAAAGCAAGCCCTGTCATTACATATCCCACCTTCTTGGTCACGAGGGGAAAGGGAGCCTCCTGTCAGACCTGAAAACAAGAGGATGGGTGAATGAACTTATGGCTGGTGGTTTAGGTGGAGGCAAGGGCTTTATGTTTTTCATTTGCAACATGGAACTCACCACTGAAGGCCAAGAGCACATTTATGATGTAGTGACATGTGTGTTTCAATATCTGGAAATGCTAAGAAGAGAAGAACCTCAAGAGTGGGTGTTCAAAGAATGTCAGGCTCTTAGTGAGGTCAAGTACAGGTTTAAAGACAAAGAAAACCCAAGATCCTATGTCTGTTCCACAGCTCGCTGTTTGCATGATTTTGGAATAGAGGATGTCATCCAGGGTCAATTTTTGATCAGACATTTTAGGCCCGACTTGATTAAGATGATTCTTTCTCATCTCGTGCCATCGAAAGTAAGGATAACGGTGATTAGCAAGGCTTTTGAAGGCAAAACGGACCTTCAGGAAGAGTGGTATGGGACCGAATACTCGGTCAGCAAAATATCTCCAAAATTTATAGAGGAATGGAATAACGTGTCGCTGAACCCATCGTTGCAACTTCCAGTAGAGAACGAATTTATTCCCACAGACTTCACAATACGAGGCAGACCAGAGGACTCCTCGCCGATTCCCAGTCTGATTAAGGATGGGCCATTATTGAAGGCTTGGTTCAAGCAAGATGATACATTTAACCTCCCTAAAGCATGTATGCTCTTTGAAATTACCAGTCCTCTAGCTTATGTTGACCCAGGGCACTGCAATATGGCACGCTTGTTTGTGGAACTGCTGAAGGATTCATTGAATGAATATGCATATAACGCAGAGATAGCAGGAGTTGACTACAAAATAGAAAACACAATGTATGGAATTTGTCTTTCTATCAAAGGATACAATCACAAACAACCAGTGCTATTGAAGAAGATTTTCGACAGAATGACGTCCTTTCAAATCGATGCTAAGCGATTTCCAGTCGTCAAAGAAAGGTGCGAGATATCTCTGAAGAACTTTGCTGCTGAACAGCCTCATCAACACGCCTTGTACTACACGTCCTTTCTTTTAGAAGAACTTGCTTGGCATAAAGACGAGCTTTTGGAAGCTCTAGAAGAAGTAACCCTGGAGAAGTTAGCTGCCTTTATTCCTAACTTGTTAGCAAGACTTCATGTCGAGTGTTTGTTGCATGGGAACATGACAAAAGAGGAAGCTTTGGATACAGTGCATCTCGTGGAGGAGAATCTAAAGGAAAACAGTAAGACTAAACCGCTAGTTCCTGTGCAGTTAATACGACACAGAGAAATTCAGCTACCAAGTGGTTGTTCGTATTTGTATGAAGTGCAGAATGAAGTTCACAATAATTCTAGTTTGGAAATTTATTATCAGTGTGATCTCCAAGCCACCAAGAGCAATGTGCTTCTCGAACTGTTTTGTCAGATTATCAACGAACCGTGCTTTAATACTCTTAGGACCAAAGAACAGCTAGGATACATCGTTTTCAGTGGAACTAGGAGATGCAATGGTGCTCAGGGTCTTCATTTTCTAATACAATCAGAGAAAGAACCTACCTTGTTGGATTCACGTGTGGAGAATTTCATTCTGGAAGTTGAGGATTACATTCAGTCGATGTCAGATCAAGAATTTAGAAATCACGTAGAGGCATTAGCTGTGAGAAGACTAGACAAACCGAAGAAACTCTCCTCAGAATGCACAAAGCACTGGAAAGAGATTTTGTCGCGACAATACAATTTTGACAGAGATAACGTTGAGGTTGCATTTTTAATGACAGTGAAAAAGGAAGACATACTCACATTTTATAAGGATCTTATCGCTTTCAAAGCACCAAGACGTCACAAGTTGGCTGTTTATATCCTTTCTAAGAGCATGTCGAAGACTGTGTTAGAGAAAGGCATCAACCATGCCGTAGAAAACGCTGAAGAAGACGATACGAATTCTCAGTCTGCGCCAACAATTATTGACGACGTTGCAGCGTTCAAGAGCAGTTTGCCTCTGTTTCCCGTCGTGCCTGCGTACCACAGTAAACCCACCAAATCCAAGCTGTGA

Transcript

asel_s0008.g50.t1

CTAGTGATTTGAAGAAAAACTGTAAATTTTAACGTGAAAACGAAGCCACCTTGGGGTAGGAATAAACTTTTTGAGACTTTCGACAATAACTGAAAAGGATCGCGACGAAATACTTAAATTTGTTCTCCGAAATCCAAGGAAATCTGGAGTCTTGGGCCCGCATTTATTTCATCTGATCTGCTGCTTCTTGTGAAATCCTCGTGTTGGAATTGAAATGCCAATGGAGGGAGTAAAGAAAATTTTCAACGAAATTCCCAAATCGCCCCGCGATGACAGGCAGTATCGGGGTTTACAACTGAAAAATGAAATGAAAGTTTTGGTTATTAGTGACCCCAGCACAGACAAATCAGCAGCCGCGATGGATGTACACATTGGTAATTTGAGTGACCCAGATGATTTCCCAGGTCTTGCGCATTTTTGTGAACACATGTTATTTCTTGGAACTGAAAAGTATCCATCAGAGAATTCGTTCACTCAGTTTTTAAGTGAAAATGGTGGATCATCTAATGCATTCACAGGAGGTGAACACACCAACTTTTTCTTTGATATCAAACATGAATGTTTGAATGAAGCTTTAGATAGATTTGGACAGTTCTTCCTTTGTCCGTTATTCAATTCAGATGCAACAGATAGGGAAGTCAATGCCGTTGAATCAGAACATCTGAAGAATATCTTAAATGATTCTTGGAGGTTAAATCAACTTGATAAGTCTACGGTGGATCCATCGCACCCATTCAGTAGATTTGGAACAGGTAACAAACTGACGCTTGACACGCGACCAAAGGAAAAAGGGCTCAGTATACGAGATGAGCTTCTTAAATTTCACAGCTCCTTCTACTCGGCCAATATCATGGCACTTGTGGTTCTTGGCAGAGAATCCCTTGATGATCTGACAAATCTCACCATAAAGCTCTTCTCAGATGCTGAAGATAAATGCATTGCAATTCCTGAGTTCCCTGTGCATCCATATGGCGATAAACAGTTACAGGTAGAATTCAAAGTGGTGCCTGTGAAAGACATAAAACACCTGAACATTTCATTTCCAATACCAGATGTTTCACAACATTATGAAAGCAAGCCCTGTCATTACATATCCCACCTTCTTGGTCACGAGGGGAAAGGGAGCCTCCTGTCAGACCTGAAAACAAGAGGATGGGTGAATGAACTTATGGCTGGTGGTTTAGGTGGAGGCAAGGGCTTTATGTTTTTCATTTGCAACATGGAACTCACCACTGAAGGCCAAGAGCACATTTATGATGTAGTGACATGTGTGTTTCAATATCTGGAAATGCTAAGAAGAGAAGAACCTCAAGAGTGGGTGTTCAAAGAATGTCAGGCTCTTAGTGAGGTCAAGTACAGGTTTAAAGACAAAGAAAACCCAAGATCCTATGTCTGTTCCACAGCTCGCTGTTTGCATGATTTTGGAATAGAGGATGTCATCCAGGGTCAATTTTTGATCAGACATTTTAGGCCCGACTTGATTAAGATGATTCTTTCTCATCTCGTGCCATCGAAAGTAAGGATAACGGTGATTAGCAAGGCTTTTGAAGGCAAAACGGACCTTCAGGAAGAGTGGTATGGGACCGAATACTCGGTCAGCAAAATATCTCCAAAATTTATAGAGGAATGGAATAACGTGTCGCTGAACCCATCGTTGCAACTTCCAGTAGAGAACGAATTTATTCCCACAGACTTCACAATACGAGGCAGACCAGAGGACTCCTCGCCGATTCCCAGTCTGATTAAGGATGGGCCATTATTGAAGGCTTGGTTCAAGCAAGATGATACATTTAACCTCCCTAAAGCATGTATGCTCTTTGAAATTACCAGTCCTCTAGCTTATGTTGACCCAGGGCACTGCAATATGGCACGCTTGTTTGTGGAACTGCTGAAGGATTCATTGAATGAATATGCATATAACGCAGAGATAGCAGGAGTTGACTACAAAATAGAAAACACAATGTATGGAATTTGTCTTTCTATCAAAGGATACAATCACAAACAACCAGTGCTATTGAAGAAGATTTTCGACAGAATGACGTCCTTTCAAATCGATGCTAAGCGATTTCCAGTCGTCAAAGAAAGGTGCGAGATATCTCTGAAGAACTTTGCTGCTGAACAGCCTCATCAACACGCCTTGTACTACACGTCCTTTCTTTTAGAAGAACTTGCTTGGCATAAAGACGAGCTTTTGGAAGCTCTAGAAGAAGTAACCCTGGAGAAGTTAGCTGCCTTTATTCCTAACTTGTTAGCAAGACTTCATGTCGAGTGTTTGTTGCATGGGAACATGACAAAAGAGGAAGCTTTGGATACAGTGCATCTCGTGGAGGAGAATCTAAAGGAAAACAGTAAGACTAAACCGCTAGTTCCTGTGCAGTTAATACGACACAGAGAAATTCAGCTACCAAGTGGTTGTTCGTATTTGTATGAAGTGCAGAATGAAGTTCACAATAATTCTAGTTTGGAAATTTATTATCAGTGTGATCTCCAAGCCACCAAGAGCAATGTGCTTCTCGAACTGTTTTGTCAGATTATCAACGAACCGTGCTTTAATACTCTTAGGACCAAAGAACAGCTAGGATACATCGTTTTCAGTGGAACTAGGAGATGCAATGGTGCTCAGGGTCTTCATTTTCTAATACAATCAGAGAAAGAACCTACCTTGTTGGATTCACGTGTGGAGAATTTCATTCTGGAAGTTGAGGATTACATTCAGTCGATGTCAGATCAAGAATTTAGAAATCACGTAGAGGCATTAGCTGTGAGAAGACTAGACAAACCGAAGAAACTCTCCTCAGAATGCACAAAGCACTGGAAAGAGATTTTGTCGCGACAATACAATTTTGACAGAGATAACGTTGAGGTTGCATTTTTAATGACAGTGAAAAAGGAAGACATACTCACATTTTATAAGGATCTTATCGCTTTCAAAGCACCAAGACGTCACAAGTTGGCTGTTTATATCCTTTCTAAGAGCATGTCGAAGACTGTGTTAGAGAAAGGCATCAACCATGCCGTAGAAAACGCTGAAGAAGACGATACGAATTCTCAGTCTGCGCCAACAATTATTGACGACGTTGCAGCGTTCAAGAGCAGTTTGCCTCTGTTTCCCGTCGTGCCTGCGTACCACAGTAAACCCACCAAATCCAAGCTGTGAGCAACATATGTCCACATTTCCTAAACCTCCGAAGAAGCAACGCGTCTAAGCTTAGAATCACAGGAACACCAACCAAAGATCTTTGCTTTTAACCATCAAATGGTTGTTTCGCCCTCTTTCACCGTTCATATCATGAGCAGATTCAAGATGTAAAGCCCACTGCTCCTTATTATTACTTTTTGCTGTAACACCACCACTCATGCAAGCCCTGCCTCTTGAATGCCAAATGAGAGTGATAGAGGATTCTTGTTATGGACTTTTTATCTTATCTATTTATCATATAGGTAATTCAGCAGTGCTCTTGTtatggtgcttatgagcaaccactgcgacgatagtgacaagaacttcacaaatttgcacatttaaccatgtgaaaaataagtttgtgcgtttgcagccatgcacgagcgttcagcgacgcataagaatttgttttacagttgtgtggacgacatcagcacttgacgagaaatgttttcttttctctttctatccaaaactgctcgtaccaattgaattcccggatagaagtatgcattttgcaagccaaataatagagaaatgactgccgaaatacgaatttgtacttaaagatgacattctcgtcttagtcgatgtcgACATATCTACTGACGTTGTGTTTTCCGAAGTGTAGCGCGATTACAAAGCCAATTATtaatgccaatgataaggttaattaaagttaattaaccgtagtaatgatgatggtgataattacaataataatgaaaatATTCCCCATCGGTTGAACAGAGTGttttgttttgtttgttggttttttttttgtttgtttgttttttAACTTTTAAACGTCATTGCGCACAACCCTAATCATTTTTCAGCGGAGCATTTGCCACCAAAGAAATCACTTTTAAAACTGGTGCAATGTCTTAAATATTCCATATTAAATCCTGTTCGATTGGGCTAACTTTAACCTCAGCCCAGTCATAAGTCATGAGTGATGTACTTTTATAGATCGCTTTCATAATGGCCATCACATTTTAAGGCCCCATTCCAACGTTGCACTTCTGCCGTTTCGAAGTCAATTCAACTGAGTTCGACACGGCAGAAGTGCGACATCCGAATCACCTGTCGAATTTCTGCCGCAAGTTCGACAGGCTGCGGCACCGATTCAAGCATCGAATTTCCCGCCTTGTCGAATCAGATGCAGACATTTTAATTTAGGAACATTTGTTTATTGACTGCGCATGCCTTTAATTAAGCAGTAAACCCAACATGAAAATAAACATTGCACAATTAAACTCGACGTctgggcccagttgttcgaaagccggttaccttagtccaggattagcgtaaacttgttggtgaaaatttctttctcttatttctaattttcaagattgatttcttctaacgtaaagtttatccgaatatcagccttgaacagcatttgggagtagagaaaaacactggttggtaaatttttagtctgggattagtgttaatcggcttttgaacaaccaggcccTGAATTGGCTGTCGAACTTTGGTCCAACTTTTGTCGAACTCAATTGGATTAAGTTCGAACGACAAaatattcttttgtctcgttgctattaaacaagcctttctaacctcgctgtcatgggcaaaattcaaaaggctatttaaactaaagtgaagccactaggtctaattaacataaagacaaaggaataacaaataaactgccatttatgaa

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P14735	Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4
P35559	Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1
Q24K02	Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001147 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00675 all species →	Peptidase_M16	Insulinase (Peptidase family M16)	Family	Interproscan
PF16187 all species →	Peptidase_M16_M	Middle or third domain of peptidase_M16	Family	Interproscan
PF05193 all species →	Peptidase_M16_C	Peptidase M16 inactive domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR011765 all species →	Domain	Peptidase M16, N-terminal	Interproscan
IPR011249 all species →	Homologous_superfamily	Metalloenzyme, LuxS/M16 peptidase-like	Interproscan
IPR032632 all species →	Domain	Peptidase M16, middle/third domain	Interproscan
IPR007863 all species →	Domain	Peptidase M16, C-terminal	Interproscan
IPR050626 all species →	Family	Peptidase M16	Interproscan
IPR001431 all species →	Binding_site	Peptidase M16, zinc-binding site	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR43690 all species →	NARDILYSIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0046872 all species →	Molecular Function	metal ion binding	Interproscan
GO:0004222 all species →	Molecular Function	metalloendopeptidase activity	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0043171 all species →	Biological Process	peptide catabolic process	Interproscan
GO:0051603 all species →	Biological Process	proteolysis involved in protein catabolic process	Interproscan
GO:0006508 all species →	Biological Process	proteolysis	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01408	IDE, ide; insulysin	EC:3.4.24.56	Peptidases and inhibitors	ko01002	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of asel_s0008.g50.t1 across 24 RNA-seq samples of Acropora selago. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

24Samples

22TPM > 0

1Conditions

17.3Max TPM

7.3Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
coral larvae	24	22	7.30	17.28

Per sample · hover a bar for the full sample record

Show the sample table (24 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR14308005	coral larvae	coral larvae	not recorded	not recorded	SRP315987	17.28
SRR14308024	coral larvae	coral larvae	not recorded	not recorded	SRP315987	10.05
SRR14308027	coral larvae	coral larvae	not recorded	not recorded	SRP315987	9.84
SRR14308008	coral larvae	coral larvae	not recorded	not recorded	SRP315987	9.64
SRR14308015	coral larvae	coral larvae	not recorded	not recorded	SRP315987	9.56
SRR14308004	coral larvae	coral larvae	not recorded	not recorded	SRP315987	8.30
SRR14308013	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.95
SRR14308017	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.93
SRR14308012	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.85
SRR14308021	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.63
SRR14308019	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.53
SRR14308006	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.41
SRR14308011	coral larvae	coral larvae	not recorded	not recorded	SRP315987	7.22
SRR14308010	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.70
SRR14308023	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.62
SRR14308007	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.61
SRR14308022	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.52
SRR14308026	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.45
SRR14308014	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.21
SRR14308025	coral larvae	coral larvae	not recorded	not recorded	SRP315987	6.05
SRR14308016	coral larvae	coral larvae	not recorded	not recorded	SRP315987	5.92
SRR14308020	coral larvae	coral larvae	not recorded	not recorded	SRP315987	5.83
SRR14308009	coral larvae	coral larvae	not recorded	not recorded	SRP315987	0.00
SRR14308018	coral larvae	coral larvae	not recorded	not recorded	SRP315987	0.00

Source: CnidoSite RNA-seq expression matrices (ASELA_TPM, StringTie quantification over 24 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora selago tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	38	asel_s0319.g5.t1	0.956177861618198
Negatively correlated	8	asel_s0508.g1.t1	-0.863388150147887

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora selago, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

DNA methylation (bisulphite samples)

Sample	Methylation profile
Coral_Fragment_Parent	open
Larval_Pool_Offspring	open

The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →