Detailed information of asel_s0033.g23.t1 in Acropora selago

Genomic Location: sc0000033_pilon:258858...286755
NR annotation: XP_029191416.2, focal adhesion kinase 1-like isoform X1 [Acropora millepora]
Species Acropora selago · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q91738Focal adhesion kinase 1 OS=Xenopus laevis OX=8355 GN=ptk2 PE=2 SV=2
Q00944Focal adhesion kinase 1 OS=Gallus gallus OX=9031 GN=PTK2 PE=1 SV=2
P34152Focal adhesion kinase 1 OS=Mus musculus OX=10090 GN=Ptk2 PE=1 SV=4
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003173 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF21477
all species →
FERM_C_FAK1FAK1/PYK2, FERM domain C-lobeDomainInterproscan
PF03623
all species →
Focal_ATFocal adhesion targeting regionDomainInterproscan
PF07714
all species →
PK_Tyr_Ser-ThrProtein tyrosine and serine/threonine kinaseDomainInterproscan
PF00373
all species →
FERM_MFERM central domainDomainInterproscan
PF18038
all species →
FERM_N_2FERM N-terminal domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR001245
all species →
DomainSerine-threonine/tyrosine-protein kinase, catalytic domainInterproscan
IPR011993
all species →
Homologous_superfamilyPH-like domain superfamilyInterproscan
IPR000719
all species →
DomainProtein kinase domainInterproscan
IPR020635
all species →
DomainTyrosine-protein kinase, catalytic domainInterproscan
IPR019748
all species →
DomainFERM central domainInterproscan
IPR049385
all species →
DomainFAK1-like, FERM domain C-lobeInterproscan
IPR019749
all species →
DomainBand 4.1 domainInterproscan
IPR036137
all species →
Homologous_superfamilyFocal adhesion kinase, targeting (FAT) domain superfamilyInterproscan
IPR005189
all species →
DomainFocal adhesion kinase, targeting (FAT) domainInterproscan
IPR014352
all species →
Homologous_superfamilyFERM/acyl-CoA-binding protein superfamilyInterproscan
IPR000299
all species →
DomainFERM domainInterproscan
IPR017441
all species →
Binding_siteProtein kinase, ATP binding siteInterproscan
IPR035963
all species →
Homologous_superfamilyFERM superfamily, second domainInterproscan
IPR029071
all species →
Homologous_superfamilyUbiquitin-like domain superfamilyInterproscan
IPR011009
all species →
Homologous_superfamilyProtein kinase-like domain superfamilyInterproscan
IPR008266
all species →
Active_siteTyrosine-protein kinase, active siteInterproscan
IPR041784
all species →
DomainFAK1/PYK2, FERM domain C-lobeInterproscan
IPR041390
all species →
DomainFocal adhesion kinase, N-terminalInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR46221
all species →
FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBERInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0004672
all species →
Molecular Functionprotein kinase activityInterproscan
GO:0006468
all species →
Biological Processprotein phosphorylationInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan
GO:0004713
all species →
Molecular Functionprotein tyrosine kinase activityInterproscan
GO:0005925
all species →
Cellular Componentfocal adhesionInterproscan
GO:0007172
all species →
Biological Processsignal complex assemblyInterproscan
GO:0005856
all species →
Cellular ComponentcytoskeletonInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K05725PTK2, FAK; focal adhesion kinase 1EC:2.7.10.2
Protein phosphatases and associated proteinsko01009deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of asel_s0033.g23.t1 across 24 RNA-seq samples of Acropora selago. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

24Samples
22TPM > 0
1Conditions
8.7Max TPM
5.4Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
coral larvae 24 22 5.35 8.69

Per sample · hover a bar for the full sample record

Show the sample table (24 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR14308018 coral larvae coral larvae not recorded not recorded SRP315987 8.69
SRR14308004 coral larvae coral larvae not recorded not recorded SRP315987 8.18
SRR14308006 coral larvae coral larvae not recorded not recorded SRP315987 7.46
SRR14308015 coral larvae coral larvae not recorded not recorded SRP315987 7.00
SRR14308008 coral larvae coral larvae not recorded not recorded SRP315987 6.84
SRR14308013 coral larvae coral larvae not recorded not recorded SRP315987 6.32
SRR14308010 coral larvae coral larvae not recorded not recorded SRP315987 6.17
SRR14308024 coral larvae coral larvae not recorded not recorded SRP315987 6.15
SRR14308026 coral larvae coral larvae not recorded not recorded SRP315987 6.00
SRR14308027 coral larvae coral larvae not recorded not recorded SRP315987 5.97
SRR14308025 coral larvae coral larvae not recorded not recorded SRP315987 5.93
SRR14308012 coral larvae coral larvae not recorded not recorded SRP315987 5.48
SRR14308011 coral larvae coral larvae not recorded not recorded SRP315987 5.39
SRR14308021 coral larvae coral larvae not recorded not recorded SRP315987 5.28
SRR14308017 coral larvae coral larvae not recorded not recorded SRP315987 5.20
SRR14308022 coral larvae coral larvae not recorded not recorded SRP315987 5.14
SRR14308007 coral larvae coral larvae not recorded not recorded SRP315987 5.05
SRR14308023 coral larvae coral larvae not recorded not recorded SRP315987 4.85
SRR14308016 coral larvae coral larvae not recorded not recorded SRP315987 4.79
SRR14308014 coral larvae coral larvae not recorded not recorded SRP315987 4.55
SRR14308019 coral larvae coral larvae not recorded not recorded SRP315987 4.52
SRR14308020 coral larvae coral larvae not recorded not recorded SRP315987 3.47
SRR14308005 coral larvae coral larvae not recorded not recorded SRP315987 0.00
SRR14308009 coral larvae coral larvae not recorded not recorded SRP315987 0.00

Source: CnidoSite RNA-seq expression matrices (ASELA_TPM, StringTie quantification over 24 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora selago tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated33asel_s0127.g19.t10.924036001016015
Negatively correlated5asel_s0026.g98.t1-0.813422726076034

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora selago, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

DNA methylation (bisulphite samples)

SampleMethylation profile
Coral_Fragment_Parentopen
Larval_Pool_Offspringopen

The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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