Genomic Location: sc0000075_pilon:590271...685550
NR annotation: XP_044175947.1, delta-1-pyrroline-5-carboxylate synthase-like isoform X3 [Acropora millepora]
Species Acropora selago · all data for this species · gene families
| CDS |
| asel_s0075.g22.t2 |
| Transcript |
| asel_s0075.g22.t2 |
| Protein |
| asel_s0075.g22.t2 |
| UniProt accession | Description |
|---|---|
| P54886 | Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2 |
| Q5R4M8 | Delta-1-pyrroline-5-carboxylate synthase OS=Pongo abelii OX=9601 GN=ALDH18A1 PE=2 SV=1 |
| Q9Z110 | Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus OX=10090 GN=Aldh18a1 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002033 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00171 all species → | Aldedh | Aldehyde dehydrogenase family | Family | Interproscan |
| PF00696 all species → | AA_kinase | Amino acid kinase family | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000965 all species → | Domain | GPR domain | Interproscan |
| IPR016163 all species → | Homologous_superfamily | Aldehyde dehydrogenase, C-terminal | Interproscan |
| IPR036393 all species → | Homologous_superfamily | Acetylglutamate kinase-like superfamily | Interproscan |
| IPR015590 all species → | Domain | Aldehyde dehydrogenase domain | Interproscan |
| IPR005766 all species → | Family | Delta l-pyrroline-5-carboxylate synthetase | Interproscan |
| IPR016162 all species → | Homologous_superfamily | Aldehyde dehydrogenase, N-terminal | Interproscan |
| IPR041744 all species → | Domain | Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain | Interproscan |
| IPR005715 all species → | Family | Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase | Interproscan |
| IPR019797 all species → | Conserved_site | Glutamate 5-kinase, conserved site | Interproscan |
| IPR001057 all species → | Family | Glutamate/acetylglutamate kinase | Interproscan |
| IPR016161 all species → | Homologous_superfamily | Aldehyde/histidinol dehydrogenase | Interproscan |
| IPR001048 all species → | Domain | Aspartate/glutamate/uridylate kinase | Interproscan |
| IPR020593 all species → | Conserved_site | Gamma-glutamyl phosphate reductase GPR, conserved site | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11063 all species → | GLUTAMATE SEMIALDEHYDE DEHYDROGENASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004350 all species → | Molecular Function | glutamate-5-semialdehyde dehydrogenase activity | Interproscan |
| GO:0006561 all species → | Biological Process | proline biosynthetic process | Interproscan |
| GO:0016620 all species → | Molecular Function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Interproscan |
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0003824 all species → | Molecular Function | catalytic activity | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0004349 all species → | Molecular Function | glutamate 5-kinase activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0016301 all species → | Molecular Function | kinase activity | Interproscan |
| GO:0005739 all species → | Cellular Component | mitochondrion | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K12657 | ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase | EC:2.7.2.11 EC:1.2.1.41 | Arginine and proline metabolism | ko00330 | deepkoala |
Transcript abundance of asel_s0075.g22.t2 across 24 RNA-seq samples of Acropora selago. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| coral larvae | 24 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR14308004 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308005 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308006 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308007 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308008 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308009 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308010 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308011 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308012 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308013 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308014 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308015 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308016 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308017 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308018 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308019 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308020 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308021 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308022 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308023 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308024 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308025 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308026 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
| SRR14308027 | coral larvae | coral larvae | not recorded | not recorded | SRP315987 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (ASELA_TPM,
StringTie quantification over 24 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora selago tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 0 | not in this network | - |
| Negatively correlated | 0 | not in this network | - |
This gene has no edge at all in the Acropora selago network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora selago, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
| Sample | Methylation profile |
|---|---|
| Coral_Fragment_Parent | open |
| Larval_Pool_Offspring | open |
The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
