Genomic Location: s032:47536...93835
NR annotation: XP_020614421.1, nitric oxide synthase, brain-like [Orbicella faveolata]
Species Fimbriaphyllia ancora · all data for this species · gene families
| CDS |
| eanc_s032.g0002.t1 |
| Transcript |
| eanc_s032.g0002.t1 |
| Protein |
| eanc_s032.g0002.t1 |
| UniProt accession | Description |
|---|---|
| Q9Z0J4 | Nitric oxide synthase 1 OS=Mus musculus OX=10090 GN=Nos1 PE=1 SV=1 |
| P29475 | Nitric oxide synthase 1 OS=Homo sapiens OX=9606 GN=NOS1 PE=1 SV=2 |
| P29476 | Nitric oxide synthase 1 OS=Rattus norvegicus OX=10116 GN=Nos1 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001036 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00258 all species → | Flavodoxin_1 | Flavodoxin | Domain | Interproscan |
| PF00667 all species → | FAD_binding_1 | FAD binding domain | Domain | Interproscan |
| PF02898 all species → | NO_synthase | Nitric oxide synthase, oxygenase domain | Domain | Interproscan |
| PF00175 all species → | NAD_binding_1 | Oxidoreductase NAD-binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001094 all species → | Domain | Flavodoxin-like | Interproscan |
| IPR029039 all species → | Homologous_superfamily | Flavoprotein-like superfamily | Interproscan |
| IPR039261 all species → | Homologous_superfamily | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Interproscan |
| IPR008254 all species → | Domain | Flavodoxin/nitric oxide synthase | Interproscan |
| IPR044943 all species → | Homologous_superfamily | Nitric oxide synthase, domain 1 superfamily | Interproscan |
| IPR050607 all species → | Family | Nitric Oxide Synthase (NOS) | Interproscan |
| IPR036119 all species → | Homologous_superfamily | Nitric oxide synthase, N-terminal domain superfamily | Interproscan |
| IPR017927 all species → | Domain | FAD-binding domain, ferredoxin reductase-type | Interproscan |
| IPR003097 all species → | Domain | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | Interproscan |
| IPR044944 all species → | Homologous_superfamily | Nitric oxide synthase, domain 3 superfamily | Interproscan |
| IPR004030 all species → | Domain | Nitric oxide synthase, N-terminal | Interproscan |
| IPR001433 all species → | Domain | Oxidoreductase FAD/NAD(P)-binding | Interproscan |
| IPR044940 all species → | Homologous_superfamily | Nitric oxide synthase, domain 2 superfamily | Interproscan |
| IPR023173 all species → | Homologous_superfamily | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Interproscan |
| IPR001709 all species → | Domain | Flavoprotein pyridine nucleotide cytochrome reductase | Interproscan |
| IPR012144 all species → | Family | Nitric-oxide synthase, eukaryote | Interproscan |
| IPR017938 all species → | Homologous_superfamily | Riboflavin synthase-like beta-barrel | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43410 all species → | NITRIC OXIDE SYNTHASE OXYGENASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0010181 all species → | Molecular Function | FMN binding | Interproscan |
| GO:0004517 all species → | Molecular Function | nitric-oxide synthase activity | Interproscan |
| GO:0006809 all species → | Biological Process | nitric oxide biosynthetic process | Interproscan |
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0005516 all species → | Molecular Function | calmodulin binding | Interproscan |
| GO:0020037 all species → | Molecular Function | heme binding | Interproscan |
| GO:0050660 all species → | Molecular Function | flavin adenine dinucleotide binding | Interproscan |
| GO:0050661 all species → | Molecular Function | NADP binding | Interproscan |
eanc_s032.g0002.t1.Transcript abundance of eanc_s032.g0002.t1 across 18 RNA-seq samples of Fimbriaphyllia ancora. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| ovaries | 11 | 8 | 17.79 | 72.51 | |
| testes | 5 | 4 | 11.92 | 25.69 | |
| Tentacles | 1 | 0 | 0.00 | 0.00 | |
| Mouth and pharynx | 1 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| DRR235381 | ovaries | ovaries | oocytes with 'U'-like germinal vesicles\, >276 um in diameter and GVBD | not recorded | DRP006537 | 72.51 |
| DRR235382 | ovaries | ovaries | oocytes with 'U'-like germinal vesicles\, >276 um in diameter and GVBD | not recorded | DRP006537 | 34.75 |
| DRR235377 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 126-200 um in diameter | not recorded | DRP006537 | 26.35 |
| DRR235380 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 201-275 um in diameter | not recorded | DRP006537 | 16.48 |
| DRR235372 | ovaries | ovaries | oocytes with cytoplasmic polarization\, <125 um in diameter | not recorded | DRP006537 | 13.57 |
| DRR235383 | ovaries | ovaries | oocytes with 'U'-like germinal vesicles\, >276 um in diameter and GVBD | not recorded | DRP006537 | 12.36 |
| DRR235378 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 201-275 um in diameter | not recorded | DRP006537 | 11.82 |
| DRR235376 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 126-200 um in diameter | not recorded | DRP006537 | 7.90 |
| DRR235374 | ovaries | ovaries | oocytes with cytoplasmic polarization\, <125 um in diameter | not recorded | DRP006537 | 0.00 |
| DRR235375 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 126-200 um in diameter | not recorded | DRP006537 | 0.00 |
| DRR235379 | ovaries | ovaries | oocytes with accumulation of yolk and other components\, 201-275 um in diameter | not recorded | DRP006537 | 0.00 |
| DRR235387 | testes | testes | spermatogonia and primary spermatocytes | not recorded | DRP006537 | 25.69 |
| DRR235389 | testes | testes | spermatogonia and primary spermatocytes | not recorded | DRP006537 | 15.41 |
| DRR235385 | testes | testes | spermatogonia | not recorded | DRP006537 | 13.61 |
| DRR235384 | testes | testes | spermatogonia | not recorded | DRP006537 | 4.91 |
| DRR235386 | testes | testes | spermatogonia | not recorded | DRP006537 | 0.00 |
| DRR397929 | Tentacles | Tentacles | not recorded | not recorded | DRP011835 | 0.00 |
| DRR397944 | Mouth and pharynx | Mouth and pharynx | not recorded | not recorded | DRP011835 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (FANCO_TPM,
StringTie quantification over 18 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Fimbriaphyllia ancora tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 13 | eanc_s083.g0056.t1 | 0.920772345750486 |
| Negatively correlated | 3 | eanc_s074.g0073.t1 | -0.529746033003816 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Fimbriaphyllia ancora, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
