Genomic Location: chr17:20082718...20172044
NR annotation: XP_031572908.1, apoptotic protease-activating factor 1-like [Actinia tenebrosa]
| CDS | |||||
| evm.model.ptg000016l.30 | |||||
| Transcript |
| evm.model.ptg000016l.30 |
| Protein |
| evm.model.ptg000016l.30 |
| Uniprot term | Description | ||||
|---|---|---|---|---|---|
| O14727 | Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2 | ||||
| O88879 | Apoptotic protease-activating factor 1 OS=Mus musculus OX=10090 GN=Apaf1 PE=1 SV=3 | ||||
| Q9EPV5 | Apoptotic protease-activating factor 1 OS=Rattus norvegicus OX=10116 GN=Apaf1 PE=1 SV=1 |
| Gene family | Subfamily |
|---|---|
| Ubiquitin Family | UBD|Other|Beta-prp |
| Ubiquitin Family | E3|E3 adaptor Cullin RING|CDC20 |
| Ubiquitin Family | E3|E3 adaptor Cullin RING|DWD |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF21296 | APAF-1-like_WHD | Apoptotic protease-activating factor 1-like, winged-helix domain | Domain | Interproscan |
| PF00931 | NB-ARC | NB-ARC domain | Domain | Interproscan |
| PF00400 | WD40 | WD domain, G-beta repeat | Repeat | Interproscan |
| PF00619 | CARD | Caspase recruitment domain | Domain | Interproscan |
| PF17908 | APAF1_C | APAF-1 helical domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR048975 | Domain | Apoptotic protease-activating factor 1, winged-helix domain | Interproscan |
| IPR011029 | Homologous_superfamily | Death-like domain superfamily | Interproscan |
| IPR001680 | Repeat | WD40 repeat | Interproscan |
| IPR002182 | Domain | NB-ARC | Interproscan |
| IPR019775 | Conserved_site | WD40 repeat, conserved site | Interproscan |
| IPR015943 | Homologous_superfamily | WD40/YVTN repeat-like-containing domain superfamily | Interproscan |
| IPR020472 | Repeat | G-protein beta WD-40 repeat | Interproscan |
| IPR027417 | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR001315 | Domain | CARD domain | Interproscan |
| IPR036322 | Homologous_superfamily | WD40-repeat-containing domain superfamily | Interproscan |
| IPR011047 | Homologous_superfamily | Quinoprotein alcohol dehydrogenase-like superfamily | Interproscan |
| IPR036388 | Homologous_superfamily | Winged helix-like DNA-binding domain superfamily | Interproscan |
| IPR042197 | Homologous_superfamily | Apoptotic protease-activating factors, helical domain | Interproscan |
| IPR041452 | Domain | APAF-1 helical domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR22845 | APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0005515 | Molecular Function | protein binding | Interproscan |
| GO:0043531 | Molecular Function | ADP binding | Interproscan |
| GO:0042981 | Biological Process | regulation of apoptotic process | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K02084 | APAF1; apoptotic protease-activating factor | - | Platinum drug resistance | ko01524 | deepkoala |
Maintained by Dr. Jiajie She from Prof. Longjun Wu's Lab & Prof. Pei-yuan Qian's Lab
Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon, Hong Kong
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