Genomic Location: chr16:17027872...17041309
NR annotation: XP_040898928.1, thioredoxin reductase 2, tandem duplicate 2 [Toxotes jaculatrix]
| CDS | |||||
| evm.model.ptg000024l.216 | |||||
| Transcript |
| evm.model.ptg000024l.216 |
| Protein |
| evm.model.ptg000024l.216 |
| Uniprot term | Description |
|---|---|
| Q9JLT4 | Thioredoxin reductase 2, mitochondrial OS=Mus musculus OX=10090 GN=Txnrd2 PE=1 SV=4 |
| Q9NNW7 | Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3 |
| Q9Z0J5 | Thioredoxin reductase 2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Txnrd2 PE=1 SV=3 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF07992 | Pyr_redox_2 | Pyridine nucleotide-disulphide oxidoreductase | Domain | Interproscan |
| PF02852 | Pyr_redox_dim | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR036188 | Homologous_superfamily | FAD/NAD(P)-binding domain superfamily | Interproscan |
| IPR006338 | Family | Thioredoxin/glutathione reductase selenoprotein | Interproscan |
| IPR023753 | Domain | FAD/NAD(P)-binding domain | Interproscan |
| IPR046952 | Family | Glutathione reductase/thioredoxin reductase-like | Interproscan |
| IPR016156 | Homologous_superfamily | FAD/NAD-linked reductase, dimerisation domain superfamily | Interproscan |
| IPR004099 | Domain | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | Interproscan |
| IPR012999 | Active_site | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Interproscan |
| IPR001100 | Family | Pyridine nucleotide-disulphide oxidoreductase, class I | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR42737 | GLUTATHIONE REDUCTASE | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0004791 | Molecular Function | thioredoxin-disulfide reductase (NADPH) activity | Interproscan |
| GO:0016491 | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0004362 | Molecular Function | glutathione-disulfide reductase (NADPH) activity | Interproscan |
| GO:0005739 | Cellular Component | mitochondrion | Interproscan |
| GO:0005829 | Cellular Component | cytosol | Interproscan |
| GO:0006749 | Biological Process | glutathione metabolic process | Interproscan |
| GO:0034599 | Biological Process | cellular response to oxidative stress | Interproscan |
| GO:0045454 | Biological Process | cell redox homeostasis | Interproscan |
| GO:0050660 | Molecular Function | flavin adenine dinucleotide binding | Interproscan |
| GO:0016668 | Molecular Function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K22182 | TXNRD; thioredoxin reductase (NADPH) | EC:1.8.1.9 | Hepatocellular carcinoma | ko05225 | deepkoala |