Genomic Location: :...
NR annotation: PCI30323.1, Fe-S cluster assembly scaffold IscU [SAR324 cluster bacterium]
| CDS | |||||
| Transcript |
| Protein |
| Uniprot term | Description |
|---|---|
| Q57074 | Iron-sulfur cluster assembly scaffold protein IscU OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) OX=71421 GN=iscU PE=1 SV=2 |
| P0ACD6 | Iron-sulfur cluster assembly scaffold protein IscU OS=Escherichia coli O157:H7 OX=83334 GN=iscU PE=1 SV=1 |
| P0ACD5 | Iron-sulfur cluster assembly scaffold protein IscU OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=iscU PE=3 SV=1 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF14529 | Exo_endo_phos_2 | Endonuclease-reverse transcriptase | Domain | Interproscan |
| PF01592 | NifU_N | NifU-like N terminal domain | Family | Interproscan |
| PF13499 | EF-hand_7 | EF-hand domain pair | Domain | Interproscan |
| PF05699 | Dimer_Tnp_hAT | hAT family C-terminal dimerisation region | Domain | Interproscan |
| PF00180 | Iso_dh | Isocitrate/isopropylmalate dehydrogenase | Domain | Interproscan |
| PF15092 | UPF0728 | Uncharacterised protein family UPF0728 | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR036691 | Homologous_superfamily | Endonuclease/exonuclease/phosphatase superfamily | Interproscan |
| IPR027124 | Family | SWR1-complex protein 5/Craniofacial development protein 1/2 | Interproscan |
| IPR005135 | Domain | Endonuclease/exonuclease/phosphatase | Interproscan |
| IPR002871 | Domain | NIF system FeS cluster assembly, NifU, N-terminal | Interproscan |
| IPR011339 | Family | Iron-sulfur cluster assembly scaffold protein IscU | Interproscan |
| IPR050145 | Family | Calmodulin and Centrin Calcium-Binding Families | Interproscan |
| IPR011992 | Homologous_superfamily | EF-hand domain pair | Interproscan |
| IPR018247 | Binding_site | EF-Hand 1, calcium-binding site | Interproscan |
| IPR002048 | Domain | EF-hand domain | Interproscan |
| IPR052035 | Family | Zinc finger BED domain-containing | Interproscan |
| IPR008906 | Domain | HAT, C-terminal dimerisation domain | Interproscan |
| IPR012337 | Homologous_superfamily | Ribonuclease H-like superfamily | Interproscan |
| IPR004429 | Family | Isopropylmalate dehydrogenase | Interproscan |
| IPR024084 | Domain | Isopropylmalate dehydrogenase-like domain | Interproscan |
| IPR019818 | Conserved_site | Isocitrate/isopropylmalate dehydrogenase, conserved site | Interproscan |
| IPR027885 | Family | Uncharacterised protein family UPF0728 | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR23227 | BUCENTAUR RELATED | Interproscan |
| PTHR10093 | IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG | Interproscan |
| PTHR23050 | CALCIUM BINDING PROTEIN | Interproscan |
| PTHR46481 | ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 | Interproscan |
| PTHR46297 | ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN | Interproscan |
| PTHR42979 | 3-ISOPROPYLMALATE DEHYDROGENASE | Interproscan |
| PTHR28448 | UPF0728 PROTEIN C10ORF53 | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0005634 | Cellular Component | nucleus | Interproscan |
| GO:0006338 | Biological Process | chromatin remodeling | Interproscan |
| GO:0003824 | Molecular Function | catalytic activity | Interproscan |
| GO:0005506 | Molecular Function | iron ion binding | Interproscan |
| GO:0016226 | Biological Process | iron-sulfur cluster assembly | Interproscan |
| GO:0051536 | Molecular Function | iron-sulfur cluster binding | Interproscan |
| GO:0005737 | Cellular Component | cytoplasm | Interproscan |
| GO:0006879 | Biological Process | intracellular iron ion homeostasis | Interproscan |
| GO:0008198 | Molecular Function | ferrous iron binding | Interproscan |
| GO:0051537 | Molecular Function | 2 iron, 2 sulfur cluster binding | Interproscan |
| GO:0005509 | Molecular Function | calcium ion binding | Interproscan |
| GO:0046983 | Molecular Function | protein dimerization activity | Interproscan |
| GO:0000122 | Biological Process | negative regulation of transcription by RNA polymerase II | Interproscan |
| GO:0000978 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Interproscan |
| GO:0001227 | Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | Interproscan |
| GO:0003862 | Molecular Function | 3-isopropylmalate dehydrogenase activity | Interproscan |
| GO:0009098 | Biological Process | L-leucine biosynthetic process | Interproscan |
| GO:0005829 | Cellular Component | cytosol | Interproscan |
| GO:0000287 | Molecular Function | magnesium ion binding | Interproscan |
| GO:0016616 | Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Interproscan |
| GO:0051287 | Molecular Function | NAD binding | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K00052 | leuB, IMDH; 3-isopropylmalate dehydrogenase | EC:1.1.1.85 | Focal adhesion | ko04510 | deepkoala |
| Valine, leucine and isoleucine biosynthesis | ko00290 | deepkoala |