Detailed information of g12324.t1 in Montipora capitata

Genomic Location: Sc0000392:24213...37582
NR annotation: XP_044163087.1, DNA mismatch repair protein Mlh3-like isoform X2 [Acropora millepora]
Species Montipora capitata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q9UHC1DNA mismatch repair protein Mlh3 OS=Homo sapiens OX=9606 GN=MLH3 PE=1 SV=3
F4JN26DNA mismatch repair protein MLH3 OS=Arabidopsis thaliana OX=3702 GN=MLH3 PE=2 SV=2
P54277PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0004862 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF08676
all species →		MutL_CMutL C terminal dimerisation domainDomainInterproscan
PF13589
all species →		HATPase_c_3Histidine kinase-, DNA gyrase B-, and HSP90-like ATPaseDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR038973
all species →		FamilyDNA mismatch repair protein MutL/Mlh/Pms-likeInterproscan
IPR042120
all species →		Homologous_superfamilyMutL, C-terminal domain, dimerisation subdomainInterproscan
IPR014790
all species →		DomainMutL, C-terminal, dimerisationInterproscan
IPR014762
all species →		Conserved_siteDNA mismatch repair, conserved siteInterproscan
IPR013507
all species →		DomainDNA mismatch repair protein, S5 domain 2-likeInterproscan
IPR037198
all species →		Homologous_superfamilyMutL, C-terminal domain superfamilyInterproscan
IPR036890
all species →		Homologous_superfamilyHistidine kinase/HSP90-like ATPase superfamilyInterproscan
IPR020568
all species →		Homologous_superfamilyRibosomal protein uS5 domain 2-type superfamilyInterproscan
IPR002099
all species →		FamilyDNA mismatch repair protein MutL/Mlh/PMSInterproscan
IPR014721
all species →		Homologous_superfamilySmall ribosomal subunit protein uS5 domain 2-type fold, subgroupInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10073
all species →		DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTLInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006298
all species →		Biological Processmismatch repairInterproscan
GO:0016887
all species →		Molecular FunctionATP hydrolysis activityInterproscan
GO:0032300
all species →		Cellular Componentmismatch repair complexInterproscan
GO:0140664
all species →		Molecular FunctionATP-dependent DNA damage sensor activityInterproscan
GO:0005524
all species →		Molecular FunctionATP bindingInterproscan
GO:0030983
all species →		Molecular Functionmismatched DNA bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K08739MLH3; DNA mismatch repair protein MLH3-DNA repair and recombination proteinsko03400deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of g12324.t1 across 48 RNA-seq samples of Montipora capitata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples
48TPM > 0
3Conditions
25.6Max TPM
15.4Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
whole organisms · ambient pH treatment 21 21 16.28 25.61
whole organisms · low pH treatment 15 15 14.46 23.44
whole organisms · extra low pH treatment pH treatment 12 12 15.21 22.34

Per sample · hover a bar for the full sample record

Show the sample table (48 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR11452262 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 25.61
SRR11452250 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 24.83
SRR11452240 whole organisms · ambient pH treatment whole organisms fertilized embryo ambient pH treatment SRP254626 22.42
SRR11452246 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 21.50
SRR11452234 whole organisms · ambient pH treatment whole organisms morula ambient pH treatment SRP254626 21.38
SRR11452232 whole organisms · ambient pH treatment whole organisms blastula ambient pH treatment SRP254626 20.62
SRR11452252 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 20.25
SRR11452263 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 17.31
SRR11452217 whole organisms · ambient pH treatment whole organisms fertilized embryo ambient pH treatment SRP254626 16.42
SRR11452233 whole organisms · ambient pH treatment whole organisms morula ambient pH treatment SRP254626 15.33
SRR11452251 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 14.84
SRR11452259 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 14.59
SRR11452260 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 14.03
SRR11452230 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 13.79
SRR11452231 whole organisms · ambient pH treatment whole organisms blastula ambient pH treatment SRP254626 13.50
SRR11452222 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 13.14
SRR11452228 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 11.37
SRR11452254 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 10.86
SRR11452243 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 10.86
SRR11452242 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 9.74
SRR11452237 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 9.40
SRR11452247 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 23.44
SRR11452218 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 19.39
SRR11452249 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 18.87
SRR11452229 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 18.83
SRR11452245 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 18.32
SRR11452216 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 17.41
SRR11452255 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 15.80
SRR11452258 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 13.51
SRR11452224 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 11.93
SRR11452253 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 11.37
SRR11452241 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 10.84
SRR11452223 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 10.69
SRR11452221 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 9.87
SRR11452236 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 8.91
SRR11452238 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 7.79
SRR11452248 whole organisms · extra low pH treatment pH treatment whole organisms prawn chip extra low pH treatment pH treatment SRP254626 22.34
SRR11452261 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 20.93
SRR11452244 whole organisms · extra low pH treatment pH treatment whole organisms prawn chip extra low pH treatment pH treatment SRP254626 19.85
SRR11452219 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 16.23
SRR11452220 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 15.41
SRR11452256 whole organisms · extra low pH treatment pH treatment whole organisms cleavage extra low pH treatment pH treatment SRP254626 13.70
SRR11452227 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 13.22
SRR11452257 whole organisms · extra low pH treatment pH treatment whole organisms cleavage extra low pH treatment pH treatment SRP254626 12.98
SRR11452225 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 12.56
SRR11452235 whole organisms · extra low pH treatment pH treatment whole organisms gastrula extra low pH treatment pH treatment SRP254626 12.19
SRR11452226 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 12.09
SRR11452239 whole organisms · extra low pH treatment pH treatment whole organisms gastrula extra low pH treatment pH treatment SRP254626 11.03

Source: CnidoSite RNA-seq expression matrices (MCAPI_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capitata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated7g8895.t10.809520796060938
Negatively correlated5g34389.t1-0.673018212815485

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capitata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
TOP