Detailed information of g12573.t1 in Acropora digitifera

Genomic Location: chr6Alt:2292394...2296156
NR annotation: XP_015776310.1, PREDICTED: mesencephalic astrocyte-derived neurotrophic factor-like [Acropora digitifera]
Species Acropora digitifera · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P55145Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3
P80513Mesencephalic astrocyte-derived neurotrophic factor OS=Bos taurus OX=9913 GN=MANF PE=1 SV=2
Q9CXI5Mesencephalic astrocyte-derived neurotrophic factor OS=Mus musculus OX=10090 GN=Manf PE=1 SV=2
 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF20145
all species →		ARMET_NARMET, N-terminalDomainInterproscan
PF10208
all species →		ARMET_CARMET, C-terminalDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR045333
all species →		FamilyARMET-likeInterproscan
IPR045332
all species →		DomainARMET, N-terminalInterproscan
IPR019345
all species →		DomainARMET, C-terminalInterproscan
IPR036361
all species →		Homologous_superfamilySAP domain superfamilyInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR12990
all species →		ARMET-LIKE PROTEINInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0005615
all species →		Cellular Componentextracellular spaceInterproscan
GO:0005783
all species →		Cellular Componentendoplasmic reticulumInterproscan
GO:0031175
all species →		Biological Processneuron projection developmentInterproscan
GO:0071542
all species →		Biological Processdopaminergic neuron differentiationInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K22556MANF, ARMET; mesencephalic astrocyte-derived neurotrophic factor-Membrane traffickingko04131deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of g12573.t1 across 39 RNA-seq samples of Acropora digitifera. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

39Samples
39TPM > 0
1Conditions
136.0Max TPM
52.1Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Coral branch 39 39 52.07 135.99

Per sample · hover a bar for the full sample record

Show the sample table (39 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR23047211 Coral branch Coral branch adult not recorded SRP416931 135.99
SRR23047235 Coral branch Coral branch adult not recorded SRP416931 104.65
SRR23047218 Coral branch Coral branch adult not recorded SRP416931 103.47
SRR23047236 Coral branch Coral branch adult not recorded SRP416931 90.31
SRR23047209 Coral branch Coral branch adult not recorded SRP416931 86.12
SRR23047237 Coral branch Coral branch adult not recorded SRP416931 81.02
SRR23047226 Coral branch Coral branch adult not recorded SRP416931 76.43
SRR23047216 Coral branch Coral branch adult not recorded SRP416931 75.18
SRR23047232 Coral branch Coral branch adult not recorded SRP416931 68.43
SRR23047212 Coral branch Coral branch adult not recorded SRP416931 67.89
SRR23047223 Coral branch Coral branch adult not recorded SRP416931 64.10
SRR23047219 Coral branch Coral branch adult not recorded SRP416931 58.94
SRR23047215 Coral branch Coral branch adult not recorded SRP416931 58.29
SRR23047217 Coral branch Coral branch adult not recorded SRP416931 57.99
SRR23047213 Coral branch Coral branch adult not recorded SRP416931 57.52
SRR23047241 Coral branch Coral branch adult not recorded SRP416931 56.09
SRR23047229 Coral branch Coral branch adult not recorded SRP416931 50.06
SRR23047224 Coral branch Coral branch adult not recorded SRP416931 49.79
SRR23047214 Coral branch Coral branch adult not recorded SRP416931 49.72
SRR23047228 Coral branch Coral branch adult not recorded SRP416931 44.99
SRR23047220 Coral branch Coral branch adult not recorded SRP416931 44.33
SRR23047244 Coral branch Coral branch adult not recorded SRP416931 43.95
SRR23047231 Coral branch Coral branch adult not recorded SRP416931 43.77
SRR23047225 Coral branch Coral branch adult not recorded SRP416931 40.92
SRR23047227 Coral branch Coral branch adult not recorded SRP416931 40.59
SRR23047238 Coral branch Coral branch adult not recorded SRP416931 38.71
SRR23047233 Coral branch Coral branch adult not recorded SRP416931 35.82
SRR23047207 Coral branch Coral branch adult not recorded SRP416931 31.32
SRR23047234 Coral branch Coral branch adult not recorded SRP416931 31.00
SRR23047239 Coral branch Coral branch adult not recorded SRP416931 30.47
SRR23047206 Coral branch Coral branch adult not recorded SRP416931 29.80
SRR23047222 Coral branch Coral branch adult not recorded SRP416931 29.77
SRR23047243 Coral branch Coral branch adult not recorded SRP416931 27.69
SRR23047242 Coral branch Coral branch adult not recorded SRP416931 25.72
SRR23047230 Coral branch Coral branch adult not recorded SRP416931 23.99
SRR23047208 Coral branch Coral branch adult not recorded SRP416931 21.80
SRR23047210 Coral branch Coral branch adult not recorded SRP416931 19.64
SRR23047221 Coral branch Coral branch adult not recorded SRP416931 18.48
SRR23047240 Coral branch Coral branch adult not recorded SRP416931 15.87

Source: CnidoSite RNA-seq expression matrices (ADIGI_TPM, StringTie quantification over 39 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora digitifera tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated37g386.t10.918030991085916
Negatively correlated42g8051.t1-0.813300028458359

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora digitifera, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

Peak calls overlapping this gene

AssaySamplePeaksRegion

No called peak overlaps this gene in 1 available assay. Either the gene is not near an accessible or marked region in those samples, or it is not represented in the peak caller’s annotation.

Browse the full epigenomic landscape of this species: DNase-seq (DHS).

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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