Genomic Location: :...
NR annotation: EDO45161.1, predicted protein [Nematostella vectensis]
| CDS | |||||
| Transcript |
| Protein |
| Uniprot term | Description | ||||
|---|---|---|---|---|---|
| Q8WTW4 | GATOR1 complex protein NPRL2 OS=Homo sapiens OX=9606 GN=NPRL2 PE=1 SV=2 | ||||
| Q9WUE4 | GATOR1 complex protein NPRL2 OS=Mus musculus OX=10090 GN=Nprl2 PE=1 SV=1 | ||||
| Q5E9U9 | GATOR1 complex protein NPRL2 OS=Bos taurus OX=9913 GN=NPRL2 PE=2 SV=1 |
| Gene family | Subfamily |
|---|---|
| Ubiquitin Family | E3|E3 activity RING|RING |
| Ubiquitin Family | E3|E3 activity RING|U-box |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00317 | Ribonuc_red_lgN | Ribonucleotide reductase, all-alpha domain | Domain | Interproscan |
| PF03477 | ATP-cone | ATP cone domain | Domain | Interproscan |
| PF02867 | Ribonuc_red_lgC | Ribonucleotide reductase, barrel domain | Family | Interproscan |
| PF13716 | CRAL_TRIO_2 | Divergent CRAL/TRIO domain | Domain | Interproscan |
| PF06218 | NPR2 | Nitrogen permease regulator 2 | Family | Interproscan |
| PF13923 | zf-C3HC4_2 | Zinc finger, C3HC4 type (RING finger) | Domain | Interproscan |
| PF08941 | USP8_interact | USP8 interacting | Domain | Interproscan |
| PF14529 | Exo_endo_phos_2 | Endonuclease-reverse transcriptase | Domain | Interproscan |
| PF02803 | Thiolase_C | Thiolase, C-terminal domain | Domain | Interproscan |
| PF00108 | Thiolase_N | Thiolase, N-terminal domain | Domain | Interproscan |
| PF00246 | Peptidase_M14 | Zinc carboxypeptidase | Domain | Interproscan |
| PF00126 | HTH_1 | Bacterial regulatory helix-turn-helix protein, lysR family | Domain | Interproscan |
| PF03466 | LysR_substrate | LysR substrate binding domain | Family | Interproscan |
| PF13516 | LRR_6 | Leucine Rich repeat | Repeat | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR013509 | Domain | Ribonucleotide reductase large subunit, N-terminal | Interproscan |
| IPR008926 | Homologous_superfamily | Ribonucleotide reductase R1 subunit, N-terminal | Interproscan |
| IPR005144 | Domain | ATP-cone domain | Interproscan |
| IPR000788 | Domain | Ribonucleotide reductase large subunit, C-terminal | Interproscan |
| IPR013346 | Domain | Ribonucleotide reductase, class I, alpha subunit, C-terminal | Interproscan |
| IPR039718 | Family | Ribonucleoside-diphosphate reductase large subunit | Interproscan |
| IPR036865 | Homologous_superfamily | CRAL-TRIO lipid binding domain superfamily | Interproscan |
| IPR001251 | Domain | CRAL-TRIO lipid binding domain | Interproscan |
| IPR009348 | Family | Nitrogen permease regulator 2-like | Interproscan |
| IPR003613 | Domain | U-box domain | Interproscan |
| IPR017907 | Conserved_site | Zinc finger, RING-type, conserved site | Interproscan |
| IPR013083 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | Interproscan |
| IPR001841 | Domain | Zinc finger, RING-type | Interproscan |
| IPR015036 | Domain | E3 ubiquitin-protein ligase NRDP1 | Interproscan |
| IPR037255 | Homologous_superfamily | NRDP1, C-terminal | Interproscan |
| IPR036691 | Homologous_superfamily | Endonuclease/exonuclease/phosphatase superfamily | Interproscan |
| IPR005135 | Domain | Endonuclease/exonuclease/phosphatase | Interproscan |
| IPR016039 | Homologous_superfamily | Thiolase-like | Interproscan |
| IPR002155 | Family | Thiolase | Interproscan |
| IPR020617 | Domain | Thiolase, C-terminal | Interproscan |
| IPR020616 | Domain | Thiolase, N-terminal | Interproscan |
| IPR020610 | Active_site | Thiolase, active site | Interproscan |
| IPR020615 | Active_site | Thiolase, acyl-enzyme intermediate active site | Interproscan |
| IPR020613 | Conserved_site | Thiolase, conserved site | Interproscan |
| IPR044882 | Homologous_superfamily | Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily | Interproscan |
| IPR000834 | Domain | Peptidase M14, carboxypeptidase A | Interproscan |
| IPR000847 | Domain | Transcription regulator HTH, LysR | Interproscan |
| IPR036390 | Homologous_superfamily | Winged helix DNA-binding domain superfamily | Interproscan |
| IPR036388 | Homologous_superfamily | Winged helix-like DNA-binding domain superfamily | Interproscan |
| IPR005119 | Domain | LysR, substrate-binding | Interproscan |
| IPR011992 | Homologous_superfamily | EF-hand domain pair | Interproscan |
| IPR052394 | Family | Leucine-rich repeat-containing protein | Interproscan |
| IPR032675 | Homologous_superfamily | Leucine-rich repeat domain superfamily | Interproscan |
| IPR001611 | Repeat | Leucine-rich repeat | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11573 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN | Interproscan |
| PTHR12991 | NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4 | Interproscan |
| PTHR10131 | TNF RECEPTOR ASSOCIATED FACTOR | Interproscan |
| PTHR18919 | ACETYL-COA C-ACYLTRANSFERASE | Interproscan |
| PTHR10816 | MYELIN TRANSCRIPTION FACTOR 1-RELATED | Interproscan |
| PTHR11705 | PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B | Interproscan |
| PTHR30537 | HTH-TYPE TRANSCRIPTIONAL REGULATOR | Interproscan |
| PTHR24114 | LEUCINE RICH REPEAT FAMILY PROTEIN | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0004748 | Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | Interproscan |
| GO:0005524 | Molecular Function | ATP binding | Interproscan |
| GO:0009263 | Biological Process | deoxyribonucleotide biosynthetic process | Interproscan |
| GO:0005971 | Cellular Component | ribonucleoside-diphosphate reductase complex | Interproscan |
| GO:0005096 | Molecular Function | GTPase activator activity | Interproscan |
| GO:0005774 | Cellular Component | vacuolar membrane | Interproscan |
| GO:0010508 | Biological Process | positive regulation of autophagy | Interproscan |
| GO:0034198 | Biological Process | cellular response to amino acid starvation | Interproscan |
| GO:1904262 | Biological Process | negative regulation of TORC1 signaling | Interproscan |
| GO:1990130 | Cellular Component | GATOR1 complex | Interproscan |
| GO:0004842 | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0016567 | Biological Process | protein ubiquitination | Interproscan |
| GO:0061630 | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:0003824 | Molecular Function | catalytic activity | Interproscan |
| GO:0016746 | Molecular Function | acyltransferase activity | Interproscan |
| GO:0016747 | Molecular Function | acyltransferase activity, transferring groups other than amino-acyl groups | Interproscan |
| GO:0005739 | Cellular Component | mitochondrion | Interproscan |
| GO:0003714 | Molecular Function | transcription corepressor activity | Interproscan |
| GO:0005634 | Cellular Component | nucleus | Interproscan |
| GO:0006357 | Biological Process | regulation of transcription by RNA polymerase II | Interproscan |
| GO:0004181 | Molecular Function | metallocarboxypeptidase activity | Interproscan |
| GO:0005615 | Cellular Component | extracellular space | Interproscan |
| GO:0006508 | Biological Process | proteolysis | Interproscan |
| GO:0008270 | Molecular Function | zinc ion binding | Interproscan |
| GO:0003700 | Molecular Function | DNA-binding transcription factor activity | Interproscan |
| GO:0006351 | Biological Process | DNA-templated transcription | Interproscan |
| GO:0043565 | Molecular Function | sequence-specific DNA binding | Interproscan |
| GO:0006355 | Biological Process | regulation of DNA-templated transcription | Interproscan |
| GO:0005515 | Molecular Function | protein binding | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K07508 | ACAA2; acetyl-CoA acyltransferase 2 | EC:2.3.1.16 | Mitochondrial biogenesis | ko03029 | deepkoala |
| DNA repair and recombination proteins | ko03400 | deepkoala | |||
| Valine, leucine and isoleucine degradation | ko00280 | deepkoala |