Genomic Location: Sc0000924:64432...88277
NR annotation: XP_044183833.1, eIF-2-alpha kinase GCN2-like [Acropora millepora]
Species Montipora capitata · all data for this species · gene families
| CDS |
| g18683.t1 |
| Transcript |
| g18683.t1 |
| Protein |
| g18683.t1 |
| UniProt accession | Description |
|---|---|
| Q9P2K8 | eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3 |
| Q9QZ05 | eIF-2-alpha kinase GCN2 OS=Mus musculus OX=10090 GN=Eif2ak4 PE=1 SV=2 |
| D4A7V9 | eIF-2-alpha kinase GCN2 OS=Rattus norvegicus OX=10116 GN=Eif2ak4 PE=3 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002771 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00069 all species → | Pkinase | Protein kinase domain | Domain | Interproscan |
| PF13393 all species → | tRNA-synt_His | Histidyl-tRNA synthetase | Domain | Interproscan |
| PF12745 all species → | HGTP_anticodon2 | Anticodon binding domain of tRNAs | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000719 all species → | Domain | Protein kinase domain | Interproscan |
| IPR036621 all species → | Homologous_superfamily | Anticodon-binding domain superfamily | Interproscan |
| IPR045864 all species → | Homologous_superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Interproscan |
| IPR017441 all species → | Binding_site | Protein kinase, ATP binding site | Interproscan |
| IPR016255 all species → | Family | eIF-2-alpha kinase Gcn2 | Interproscan |
| IPR011009 all species → | Homologous_superfamily | Protein kinase-like domain superfamily | Interproscan |
| IPR041715 all species → | Domain | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | Interproscan |
| IPR008271 all species → | Active_site | Serine/threonine-protein kinase, active site | Interproscan |
| IPR024435 all species → | Domain | Histidyl tRNA synthetase-related domain | Interproscan |
| IPR050339 all species → | Family | Cell Cycle and Stress Response Kinase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11042 all species → | EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004672 all species → | Molecular Function | protein kinase activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0006468 all species → | Biological Process | protein phosphorylation | Interproscan |
| GO:0000077 all species → | Biological Process | DNA damage checkpoint signaling | Interproscan |
| GO:0004694 all species → | Molecular Function | eukaryotic translation initiation factor 2alpha kinase activity | Interproscan |
| GO:0010998 all species → | Biological Process | regulation of translational initiation by eIF2 alpha phosphorylation | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K16196 | EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 | EC:2.7.11.1 | Protein kinases | ko01001 | deepkoala |
Transcript abundance of g18683.t1 across 48 RNA-seq samples of Montipora capitata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organisms · ambient pH treatment | 21 | 21 | 14.04 | 33.85 | |
| whole organisms · low pH treatment | 15 | 15 | 10.88 | 24.25 | |
| whole organisms · extra low pH treatment pH treatment | 12 | 12 | 12.50 | 27.97 |
Source: CnidoSite RNA-seq expression matrices (MCAPI_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.