Detailed information of g27898.t1 in Montipora capitata

Genomic Location: xfSc0000070:102743...129522
NR annotation: KAJ7388968.1, E3 ubiquitin-protein ligase nedd4 [Desmophyllum pertusum]
Species Montipora capitata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q5RBF2E3 ubiquitin-protein ligase NEDD4-like OS=Pongo abelii OX=9601 GN=NEDD4L PE=2 SV=1
P46935E3 ubiquitin-protein ligase NEDD4 OS=Mus musculus OX=10090 GN=Nedd4 PE=1 SV=3
Q96PU5E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0000813 (this species only) · gene tree & orthology
Ubiquitin familyE3|E3 activity|HECT · all ubiquitin genes in this species

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00397
all species →		WWWW domainDomainInterproscan
PF00632
all species →		HECTHECT-domain (ubiquitin-transferase)DomainInterproscan
PF00168
all species →		C2C2 domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR001202
all species →		DomainWW domainInterproscan
IPR050409
all species →		FamilyE3 ubiquitin-protein ligaseInterproscan
IPR035983
all species →		Homologous_superfamilyHECT, E3 ligase catalytic domainInterproscan
IPR036020
all species →		Homologous_superfamilyWW domain superfamilyInterproscan
IPR000569
all species →		DomainHECT domainInterproscan
IPR035892
all species →		Homologous_superfamilyC2 domain superfamilyInterproscan
IPR000008
all species →		DomainC2 domainInterproscan
IPR024928
all species →		FamilyE3 ubiquitin-protein ligase, SMURF1 typeInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11254
all species →		HECT DOMAIN UBIQUITIN-PROTEIN LIGASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0005515
all species →		Molecular Functionprotein bindingInterproscan
GO:0000209
all species →		Biological Processprotein polyubiquitinationInterproscan
GO:0005737
all species →		Cellular ComponentcytoplasmInterproscan
GO:0016567
all species →		Biological Processprotein ubiquitinationInterproscan
GO:0048814
all species →		Biological Processregulation of dendrite morphogenesisInterproscan
GO:0061630
all species →		Molecular Functionubiquitin protein ligase activityInterproscan
GO:2000650
all species →		Biological Processnegative regulation of sodium ion transmembrane transporter activityInterproscan
GO:0004842
all species →		Molecular Functionubiquitin-protein transferase activityInterproscan
GO:0006511
all species →		Biological Processubiquitin-dependent protein catabolic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K10591NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4EC:2.3.2.26
Mitochondrial biogenesisko03029deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of g27898.t1 across 48 RNA-seq samples of Montipora capitata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples
48TPM > 0
3Conditions
65.1Max TPM
28.8Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
whole organisms · ambient pH treatment 21 21 26.91 65.10
whole organisms · low pH treatment 15 15 31.89 65.06
whole organisms · extra low pH treatment pH treatment 12 12 28.35 61.14

Per sample · hover a bar for the full sample record

Show the sample table (48 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR11452252 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 65.10
SRR11452246 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 61.05
SRR11452250 whole organisms · ambient pH treatment whole organisms prawn chip ambient pH treatment SRP254626 57.17
SRR11452230 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 43.97
SRR11452228 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 42.14
SRR11452222 whole organisms · ambient pH treatment whole organisms planulae ambient pH treatment SRP254626 38.36
SRR11452237 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 35.40
SRR11452232 whole organisms · ambient pH treatment whole organisms blastula ambient pH treatment SRP254626 34.93
SRR11452243 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 34.76
SRR11452259 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 28.68
SRR11452242 whole organisms · ambient pH treatment whole organisms gastrula ambient pH treatment SRP254626 26.36
SRR11452254 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 25.03
SRR11452231 whole organisms · ambient pH treatment whole organisms blastula ambient pH treatment SRP254626 22.71
SRR11452260 whole organisms · ambient pH treatment whole organisms cleavage ambient pH treatment SRP254626 18.50
SRR11452234 whole organisms · ambient pH treatment whole organisms morula ambient pH treatment SRP254626 9.23
SRR11452233 whole organisms · ambient pH treatment whole organisms morula ambient pH treatment SRP254626 6.75
SRR11452263 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 4.08
SRR11452240 whole organisms · ambient pH treatment whole organisms fertilized embryo ambient pH treatment SRP254626 3.65
SRR11452262 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 3.45
SRR11452217 whole organisms · ambient pH treatment whole organisms fertilized embryo ambient pH treatment SRP254626 1.91
SRR11452251 whole organisms · ambient pH treatment whole organisms egg ambient pH treatment SRP254626 1.83
SRR11452245 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 65.06
SRR11452247 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 63.51
SRR11452249 whole organisms · low pH treatment whole organisms prawn chip low pH treatment SRP254626 63.00
SRR11452223 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 42.61
SRR11452221 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 37.09
SRR11452236 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 34.95
SRR11452238 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 34.49
SRR11452258 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 31.23
SRR11452224 whole organisms · low pH treatment whole organisms planulae low pH treatment SRP254626 29.78
SRR11452241 whole organisms · low pH treatment whole organisms gastrula low pH treatment SRP254626 24.01
SRR11452253 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 22.53
SRR11452255 whole organisms · low pH treatment whole organisms cleavage low pH treatment SRP254626 21.10
SRR11452216 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 4.30
SRR11452218 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 2.48
SRR11452229 whole organisms · low pH treatment whole organisms fertilized embryo low pH treatment SRP254626 2.16
SRR11452248 whole organisms · extra low pH treatment pH treatment whole organisms prawn chip extra low pH treatment pH treatment SRP254626 61.14
SRR11452244 whole organisms · extra low pH treatment pH treatment whole organisms prawn chip extra low pH treatment pH treatment SRP254626 50.02
SRR11452225 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 40.49
SRR11452227 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 35.24
SRR11452226 whole organisms · extra low pH treatment pH treatment whole organisms planulae extra low pH treatment pH treatment SRP254626 33.26
SRR11452239 whole organisms · extra low pH treatment pH treatment whole organisms gastrula extra low pH treatment pH treatment SRP254626 29.77
SRR11452235 whole organisms · extra low pH treatment pH treatment whole organisms gastrula extra low pH treatment pH treatment SRP254626 29.74
SRR11452257 whole organisms · extra low pH treatment pH treatment whole organisms cleavage extra low pH treatment pH treatment SRP254626 25.34
SRR11452256 whole organisms · extra low pH treatment pH treatment whole organisms cleavage extra low pH treatment pH treatment SRP254626 23.75
SRR11452219 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 5.38
SRR11452261 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 4.23
SRR11452220 whole organisms · extra low pH treatment pH treatment whole organisms fertilized embryo extra low pH treatment pH treatment SRP254626 1.83

Source: CnidoSite RNA-seq expression matrices (MCAPI_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capitata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated37g4848.t10.96060659864005
Negatively correlated13g11946.t1-0.903365157800224

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capitata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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