Genomic Location: Sc0000093:328942...365390
NR annotation: XP_029197633.2, LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1-like [Acropora millepora]
Species Montipora capitata · all data for this species · gene families
| CDS |
| g4897.t1 |
| Transcript |
| g4897.t1 |
| Protein |
| g4897.t1 |
| UniProt accession | Description |
|---|---|
| Q04721 | Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3 |
| O35516 | Neurogenic locus notch homolog protein 2 OS=Mus musculus OX=10090 GN=Notch2 PE=1 SV=2 |
| Q9QW30 | Neurogenic locus notch homolog protein 2 OS=Rattus norvegicus OX=10116 GN=Notch2 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003337 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF12796 all species → | Ank_2 | Ankyrin repeats (3 copies) | Repeat | Interproscan |
| PF07645 all species → | EGF_CA | Calcium-binding EGF domain | Domain | Interproscan |
| PF13857 all species → | Ank_5 | Ankyrin repeats (many copies) | Repeat | Interproscan |
| PF12661 all species → | hEGF | Human growth factor-like EGF | Domain | Interproscan |
| PF00066 all species → | Notch | LNR domain | Domain | Interproscan |
| PF07684 all species → | NODP | NOTCH protein | Family | Interproscan |
| PF00008 all species → | EGF | EGF-like domain | Domain | Interproscan |
| PF06816 all species → | NOD | NOTCH protein | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR009030 all species → | Homologous_superfamily | Growth factor receptor cysteine-rich domain superfamily | Interproscan |
| IPR000742 all species → | Domain | EGF-like domain | Interproscan |
| IPR000152 all species → | PTM | EGF-type aspartate/asparagine hydroxylation site | Interproscan |
| IPR035993 all species → | Homologous_superfamily | Notch-like domain superfamily | Interproscan |
| IPR051022 all species → | Family | Notch Signaling and Cell Fate Determination | Interproscan |
| IPR002110 all species → | Repeat | Ankyrin repeat | Interproscan |
| IPR018097 all species → | Conserved_site | EGF-like calcium-binding, conserved site | Interproscan |
| IPR036770 all species → | Homologous_superfamily | Ankyrin repeat-containing domain superfamily | Interproscan |
| IPR049883 all species → | Domain | NOTCH1 EGF-like calcium-binding domain | Interproscan |
| IPR001881 all species → | Domain | EGF-like calcium-binding domain | Interproscan |
| IPR013032 all species → | Conserved_site | EGF-like, conserved site | Interproscan |
| IPR000800 all species → | Domain | Notch domain | Interproscan |
| IPR008297 all species → | Family | Notch | Interproscan |
| IPR011656 all species → | Domain | Notch, NODP domain | Interproscan |
| IPR010660 all species → | Domain | Notch, NOD domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR24049 all species → | CRUMBS FAMILY MEMBER | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0005509 all species → | Molecular Function | calcium ion binding | Interproscan |
| GO:0007219 all species → | Biological Process | Notch signaling pathway | Interproscan |
| GO:0016020 all species → | Cellular Component | membrane | Interproscan |
| GO:0030154 all species → | Biological Process | cell differentiation | Interproscan |
| GO:0050793 all species → | Biological Process | regulation of developmental process | Interproscan |
| GO:0007275 all species → | Biological Process | multicellular organism development | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K02599 | NOTCH1; Notch 1 | - | Endocrine resistance | ko01522 | deepkoala |
Transcript abundance of g4897.t1 across 48 RNA-seq samples of Montipora capitata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organisms · ambient pH treatment | 21 | 21 | 20.41 | 47.23 | |
| whole organisms · low pH treatment | 15 | 15 | 19.77 | 50.02 | |
| whole organisms · extra low pH treatment pH treatment | 12 | 12 | 20.40 | 43.04 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR11452242 | whole organisms · ambient pH treatment | whole organisms | gastrula | ambient pH treatment | SRP254626 | 47.23 |
| SRR11452243 | whole organisms · ambient pH treatment | whole organisms | gastrula | ambient pH treatment | SRP254626 | 33.89 |
| SRR11452222 | whole organisms · ambient pH treatment | whole organisms | planulae | ambient pH treatment | SRP254626 | 33.87 |
| SRR11452237 | whole organisms · ambient pH treatment | whole organisms | gastrula | ambient pH treatment | SRP254626 | 30.90 |
| SRR11452233 | whole organisms · ambient pH treatment | whole organisms | morula | ambient pH treatment | SRP254626 | 30.33 |
| SRR11452230 | whole organisms · ambient pH treatment | whole organisms | planulae | ambient pH treatment | SRP254626 | 30.29 |
| SRR11452234 | whole organisms · ambient pH treatment | whole organisms | morula | ambient pH treatment | SRP254626 | 30.18 |
| SRR11452228 | whole organisms · ambient pH treatment | whole organisms | planulae | ambient pH treatment | SRP254626 | 30.07 |
| SRR11452232 | whole organisms · ambient pH treatment | whole organisms | blastula | ambient pH treatment | SRP254626 | 28.24 |
| SRR11452250 | whole organisms · ambient pH treatment | whole organisms | prawn chip | ambient pH treatment | SRP254626 | 20.08 |
| SRR11452259 | whole organisms · ambient pH treatment | whole organisms | cleavage | ambient pH treatment | SRP254626 | 18.74 |
| SRR11452252 | whole organisms · ambient pH treatment | whole organisms | prawn chip | ambient pH treatment | SRP254626 | 18.50 |
| SRR11452246 | whole organisms · ambient pH treatment | whole organisms | prawn chip | ambient pH treatment | SRP254626 | 17.27 |
| SRR11452260 | whole organisms · ambient pH treatment | whole organisms | cleavage | ambient pH treatment | SRP254626 | 17.19 |
| SRR11452254 | whole organisms · ambient pH treatment | whole organisms | cleavage | ambient pH treatment | SRP254626 | 14.33 |
| SRR11452231 | whole organisms · ambient pH treatment | whole organisms | blastula | ambient pH treatment | SRP254626 | 13.32 |
| SRR11452263 | whole organisms · ambient pH treatment | whole organisms | egg | ambient pH treatment | SRP254626 | 3.50 |
| SRR11452251 | whole organisms · ambient pH treatment | whole organisms | egg | ambient pH treatment | SRP254626 | 3.49 |
| SRR11452262 | whole organisms · ambient pH treatment | whole organisms | egg | ambient pH treatment | SRP254626 | 3.41 |
| SRR11452217 | whole organisms · ambient pH treatment | whole organisms | fertilized embryo | ambient pH treatment | SRP254626 | 2.05 |
| SRR11452240 | whole organisms · ambient pH treatment | whole organisms | fertilized embryo | ambient pH treatment | SRP254626 | 1.74 |
| SRR11452241 | whole organisms · low pH treatment | whole organisms | gastrula | low pH treatment | SRP254626 | 50.02 |
| SRR11452236 | whole organisms · low pH treatment | whole organisms | gastrula | low pH treatment | SRP254626 | 39.75 |
| SRR11452238 | whole organisms · low pH treatment | whole organisms | gastrula | low pH treatment | SRP254626 | 36.44 |
| SRR11452249 | whole organisms · low pH treatment | whole organisms | prawn chip | low pH treatment | SRP254626 | 21.86 |
| SRR11452245 | whole organisms · low pH treatment | whole organisms | prawn chip | low pH treatment | SRP254626 | 20.61 |
| SRR11452223 | whole organisms · low pH treatment | whole organisms | planulae | low pH treatment | SRP254626 | 19.65 |
| SRR11452221 | whole organisms · low pH treatment | whole organisms | planulae | low pH treatment | SRP254626 | 19.44 |
| SRR11452224 | whole organisms · low pH treatment | whole organisms | planulae | low pH treatment | SRP254626 | 18.52 |
| SRR11452247 | whole organisms · low pH treatment | whole organisms | prawn chip | low pH treatment | SRP254626 | 16.85 |
| SRR11452253 | whole organisms · low pH treatment | whole organisms | cleavage | low pH treatment | SRP254626 | 16.70 |
| SRR11452258 | whole organisms · low pH treatment | whole organisms | cleavage | low pH treatment | SRP254626 | 16.21 |
| SRR11452255 | whole organisms · low pH treatment | whole organisms | cleavage | low pH treatment | SRP254626 | 12.53 |
| SRR11452229 | whole organisms · low pH treatment | whole organisms | fertilized embryo | low pH treatment | SRP254626 | 3.30 |
| SRR11452218 | whole organisms · low pH treatment | whole organisms | fertilized embryo | low pH treatment | SRP254626 | 2.69 |
| SRR11452216 | whole organisms · low pH treatment | whole organisms | fertilized embryo | low pH treatment | SRP254626 | 1.93 |
| SRR11452239 | whole organisms · extra low pH treatment pH treatment | whole organisms | gastrula | extra low pH treatment pH treatment | SRP254626 | 43.04 |
| SRR11452227 | whole organisms · extra low pH treatment pH treatment | whole organisms | planulae | extra low pH treatment pH treatment | SRP254626 | 33.58 |
| SRR11452235 | whole organisms · extra low pH treatment pH treatment | whole organisms | gastrula | extra low pH treatment pH treatment | SRP254626 | 31.57 |
| SRR11452225 | whole organisms · extra low pH treatment pH treatment | whole organisms | planulae | extra low pH treatment pH treatment | SRP254626 | 31.31 |
| SRR11452226 | whole organisms · extra low pH treatment pH treatment | whole organisms | planulae | extra low pH treatment pH treatment | SRP254626 | 27.27 |
| SRR11452256 | whole organisms · extra low pH treatment pH treatment | whole organisms | cleavage | extra low pH treatment pH treatment | SRP254626 | 20.26 |
| SRR11452248 | whole organisms · extra low pH treatment pH treatment | whole organisms | prawn chip | extra low pH treatment pH treatment | SRP254626 | 19.47 |
| SRR11452244 | whole organisms · extra low pH treatment pH treatment | whole organisms | prawn chip | extra low pH treatment pH treatment | SRP254626 | 16.61 |
| SRR11452257 | whole organisms · extra low pH treatment pH treatment | whole organisms | cleavage | extra low pH treatment pH treatment | SRP254626 | 14.47 |
| SRR11452261 | whole organisms · extra low pH treatment pH treatment | whole organisms | fertilized embryo | extra low pH treatment pH treatment | SRP254626 | 2.95 |
| SRR11452219 | whole organisms · extra low pH treatment pH treatment | whole organisms | fertilized embryo | extra low pH treatment pH treatment | SRP254626 | 2.61 |
| SRR11452220 | whole organisms · extra low pH treatment pH treatment | whole organisms | fertilized embryo | extra low pH treatment pH treatment | SRP254626 | 1.67 |
Source: CnidoSite RNA-seq expression matrices (MCAPI_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Montipora capitata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 24 | g28086.t1 | 0.960286005667607 |
| Negatively correlated | 17 | g5302.t1 | -0.899062430993502 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Montipora capitata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |