Gene detail

Detailed information of g558.t1 in Calvadosia cruxmelitensis

Genomic Location: not available for this species
NR annotation: XP_047124880.1, epidermal growth factor receptor kinase substrate 8-like isoform X5 [Hydra vulgaris]
Species Calvadosia cruxmelitensis · all data for this species · gene families

Sequence

Sequence data are not available for Calvadosia cruxmelitensis.
Nucleotide and protein sequences are provided for the species whose genome annotation is complete (see annotated genomes); for this species only the assembly is archived. The functional annotation below is likewise unavailable.

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5R4H4	Epidermal growth factor receptor kinase substrate 8 OS=Pongo abelii OX=9601 GN=EPS8 PE=2 SV=2
Q12929	Epidermal growth factor receptor kinase substrate 8 OS=Homo sapiens OX=9606 GN=EPS8 PE=1 SV=1
Q08509	Epidermal growth factor receptor kinase substrate 8 OS=Mus musculus OX=10090 GN=Eps8 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000001 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0001465 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0002377 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0007094 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0008614 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0010630 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0016395 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0049975 (this species only) · gene tree & orthology
Ubiquitin family	UBD\|Other\|SH3 · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF21319 all species →	zf-FCS_1	Zinc finger, FCS-type	Domain	Interproscan
PF18016 all species →	SAM_3	SAM domain (Sterile alpha motif)	Domain	Interproscan
PF00018 all species →	SH3_1	SH3 domain	Domain	Interproscan
PF08416 all species →	PTB	Phosphotyrosine-binding domain	Domain	Interproscan
PF13927 all species →	Ig_3	Immunoglobulin domain	Domain	Interproscan
PF07679 all species →	I-set	Immunoglobulin I-set domain	Domain	Interproscan
PF00041 all species →	fn3	Fibronectin type III domain	Domain	Interproscan
PF00047 all species →	ig	Immunoglobulin domain	Domain	Interproscan
PF21202 all species →	SLX1_C	Structure-specific endonuclease subunit SLX1, C-terminal	Domain	Interproscan
PF05648 all species →	PEX11	Peroxisomal biogenesis factor 11 (PEX11)	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR012313 all species →	Domain	Zinc finger, FCS-type	Interproscan
IPR038603 all species →	Homologous_superfamily	FCS-type zinc finger superfamily	Interproscan
IPR001452 all species →	Domain	SH3 domain	Interproscan
IPR013761 all species →	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR041418 all species →	Domain	SAM domain	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan
IPR006020 all species →	Domain	PTB/PI domain	Interproscan
IPR039801 all species →	Family	Epidermal growth factor receptor kinase substrate 8-like	Interproscan
IPR013625 all species →	Domain	Tensin/EPS8 phosphotyrosine-binding domain	Interproscan
IPR036028 all species →	Homologous_superfamily	SH3-like domain superfamily	Interproscan
IPR003599 all species →	Domain	Immunoglobulin subtype	Interproscan
IPR003598 all species →	Domain	Immunoglobulin subtype 2	Interproscan
IPR003961 all species →	Domain	Fibronectin type III	Interproscan
IPR036179 all species →	Homologous_superfamily	Immunoglobulin-like domain superfamily	Interproscan
IPR013783 all species →	Homologous_superfamily	Immunoglobulin-like fold	Interproscan
IPR036116 all species →	Homologous_superfamily	Fibronectin type III superfamily	Interproscan
IPR013098 all species →	Domain	Immunoglobulin I-set	Interproscan
IPR007110 all species →	Domain	Immunoglobulin-like domain	Interproscan
IPR013151 all species →	Domain	Immunoglobulin	Interproscan
IPR048749 all species →	Domain	Structure-specific endonuclease subunit SLX1, C-terminal domain	Interproscan
IPR013083 all species →	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	Interproscan
IPR050381 all species →	Family	SLX1 structure-specific endonuclease	Interproscan
IPR008733 all species →	Family	Peroxisomal biogenesis factor 11	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12287 all species →	EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN	Interproscan
PTHR44170 all species →	PROTEIN SIDEKICK	Interproscan
PTHR20208 all species →	STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1	Interproscan
PTHR12652 all species →	PEROXISOMAL BIOGENESIS FACTOR 11	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0008270 all species →	Molecular Function	zinc ion binding	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0003779 all species →	Molecular Function	actin binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0007266 all species →	Biological Process	Rho protein signal transduction	Interproscan
GO:0035023 all species →	Biological Process	regulation of Rho protein signal transduction	Interproscan
GO:0098609 all species →	Biological Process	cell-cell adhesion	Interproscan
GO:0000724 all species →	Biological Process	double-strand break repair via homologous recombination	Interproscan
GO:0008821 all species →	Molecular Function	crossover junction DNA endonuclease activity	Interproscan
GO:0017108 all species →	Molecular Function	5'-flap endonuclease activity	Interproscan
GO:0033557 all species →	Cellular Component	Slx1-Slx4 complex	Interproscan
GO:0005778 all species →	Cellular Component	peroxisomal membrane	Interproscan
GO:0016559 all species →	Biological Process	peroxisome fission	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

No KEGG orthology assignment for g558.t1.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Calvadosia cruxmelitensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Calvadosia cruxmelitensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	sequence table not available	–
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	sequence table not available	–
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →