Gene detail

Detailed information of g569.t1 in Calvadosia cruxmelitensis

Genomic Location: not available for this species
NR annotation: XP_047128885.1, mitogen-activated protein kinase kinase kinase 15 [Hydra vulgaris]
Species Calvadosia cruxmelitensis · all data for this species · gene families

Sequence

Sequence data are not available for Calvadosia cruxmelitensis.
Nucleotide and protein sequences are provided for the species whose genome annotation is complete (see annotated genomes); for this species only the assembly is archived. The functional annotation below is likewise unavailable.

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens OX=9606 GN=MAP3K15 PE=1 SV=2
O35099	Mitogen-activated protein kinase kinase kinase 5 OS=Mus musculus OX=10090 GN=Map3k5 PE=1 SV=3
A2AQW0	Mitogen-activated protein kinase kinase kinase 15 OS=Mus musculus OX=10090 GN=Map3k15 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000000 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000098 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000139 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000157 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000477 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000559 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000768 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0001169 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0003166 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0005171 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0008158 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0012392 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0018806 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF20302 all species →	HisK-N-like	HisK-N-like globin domain of the ASK signalosome	Domain	Interproscan
PF13281 all species →	MAP3K_TRAF_bd	MAP3K TRAFs-binding domain	Repeat	Interproscan
PF19039 all species →	ASK_PH	ASK kinase PH domain	Domain	Interproscan
PF20309 all species →	DRHyd-ASK	Deoxyribohydrolase (DRHyd) domain of the ASK signalosome	Family	Interproscan
PF00069 all species →	Pkinase	Protein kinase domain	Domain	Interproscan
PF09588 all species →	YqaJ	YqaJ-like viral recombinase domain	Domain	Interproscan
PF00153 all species →	Mito_carr	Mitochondrial carrier protein	Repeat	Interproscan
PF01094 all species →	ANF_receptor	Receptor family ligand binding region	Family	Interproscan
PF00147 all species →	Fibrinogen_C	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain	Interproscan
PF00850 all species →	Hist_deacetyl	Histone deacetylase domain	Domain	Interproscan
PF12937 all species →	F-box-like	F-box-like	Domain	Interproscan
PF00743 all species →	FMO-like	Flavin-binding monooxygenase-like	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR046873 all species →	Domain	MAP3K, HisK-N-like globin domain	Interproscan
IPR025136 all species →	Domain	MAP3K, TRAFs-binding domain	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR017441 all species →	Binding_site	Protein kinase, ATP binding site	Interproscan
IPR043969 all species →	Domain	MAP3K, PH domain	Interproscan
IPR013761 all species →	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	Interproscan
IPR046872 all species →	Domain	MAP3K, deoxyribohydrolase domain	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR011604 all species →	Homologous_superfamily	PD-(D/E)XK endonuclease-like domain superfamily	Interproscan
IPR051703 all species →	Family	NF-kappa-B Signaling Regulator	Interproscan
IPR011335 all species →	Homologous_superfamily	Restriction endonuclease type II-like	Interproscan
IPR019080 all species →	Domain	YqaJ viral recombinase	Interproscan
IPR023395 all species →	Homologous_superfamily	Mitochondrial carrier domain superfamily	Interproscan
IPR018108 all species →	Repeat	Mitochondrial substrate/solute carrier	Interproscan
IPR050567 all species →	Family	Mitochondrial Carrier	Interproscan
IPR001828 all species →	Domain	Receptor, ligand binding region	Interproscan
IPR052612 all species →	Family	Atrial Natriuretic Peptide Clearance Receptor	Interproscan
IPR028082 all species →	Homologous_superfamily	Periplasmic binding protein-like I	Interproscan
IPR051666 all species →	Family	Seminal Plasma Capacitation Regulator	Interproscan
IPR002181 all species →	Domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Interproscan
IPR050373 all species →	Family	Fibrinogen C-terminal domain-containing protein	Interproscan
IPR036056 all species →	Homologous_superfamily	Fibrinogen-like, C-terminal	Interproscan
IPR014716 all species →	Homologous_superfamily	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Interproscan
IPR023801 all species →	Domain	Histone deacetylase domain	Interproscan
IPR000286 all species →	Family	Histone deacetylase family	Interproscan
IPR023696 all species →	Homologous_superfamily	Ureohydrolase domain superfamily	Interproscan
IPR003084 all species →	Family	Histone deacetylase	Interproscan
IPR050284 all species →	Family	Histone deacetylase and polyamine deacetylase	Interproscan
IPR037138 all species →	Homologous_superfamily	Histone deacetylase domain superfamily	Interproscan
IPR001810 all species →	Domain	F-box domain	Interproscan
IPR036047 all species →	Homologous_superfamily	F-box-like domain superfamily	Interproscan
IPR036188 all species →	Homologous_superfamily	FAD/NAD(P)-binding domain superfamily	Interproscan
IPR050346 all species →	Family	Flavin-containing Monooxygenases	Interproscan
IPR020946 all species →	Family	Flavin monooxygenase-like	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11584 all species →	SERINE/THREONINE PROTEIN KINASE	Interproscan
PTHR46609 all species →	EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN	Interproscan
PTHR45624 all species →	MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED	Interproscan
PTHR44755 all species →	NATRIURETIC PEPTIDE RECEPTOR 3-RELATED	Interproscan
PTHR22918 all species →	SEMINAL PLASMA PROTEIN	Interproscan
PTHR47331 all species →	PHD-TYPE DOMAIN-CONTAINING PROTEIN	Interproscan
PTHR19143 all species →	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	Interproscan
PTHR10625 all species →	HISTONE DEACETYLASE HDAC1-RELATED	Interproscan
PTHR23023 all species →	DIMETHYLANILINE MONOOXYGENASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0000165 all species →	Biological Process	MAPK cascade	Interproscan
GO:0000064 all species →	Molecular Function	L-ornithine transmembrane transporter activity	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0006810 all species →	Biological Process	transport	Interproscan
GO:0022857 all species →	Molecular Function	transmembrane transporter activity	Interproscan
GO:1990575 all species →	Biological Process	mitochondrial L-ornithine transmembrane transport	Interproscan
GO:0007165 all species →	Biological Process	signal transduction	Interproscan
GO:0017046 all species →	Molecular Function	peptide hormone binding	Interproscan
GO:0038023 all species →	Molecular Function	signaling receptor activity	Interproscan
GO:0008201 all species →	Molecular Function	heparin binding	Interproscan
GO:0009986 all species →	Cellular Component	cell surface	Interproscan
GO:0005615 all species →	Cellular Component	extracellular space	Interproscan
GO:0062023 all species →	Cellular Component	collagen-containing extracellular matrix	Interproscan
GO:0004407 all species →	Molecular Function	histone deacetylase activity	Interproscan
GO:0000122 all species →	Biological Process	negative regulation of transcription by RNA polymerase II	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0006357 all species →	Biological Process	regulation of transcription by RNA polymerase II	Interproscan
GO:0016575 all species →	Biological Process	obsolete histone deacetylation	Interproscan
GO:0016581 all species →	Cellular Component	NuRD complex	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0004499 all species →	Molecular Function	N,N-dimethylaniline monooxygenase activity	Interproscan
GO:0050660 all species →	Molecular Function	flavin adenine dinucleotide binding	Interproscan
GO:0050661 all species →	Molecular Function	NADP binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K04426	MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5	EC:2.7.11.25	Protein kinases	ko01001	deepkoala
K06067	HDAC1_2; histone deacetylase 1/2	EC:3.5.1.98	Chromosome and associated proteins	ko03036	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Calvadosia cruxmelitensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Calvadosia cruxmelitensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	sequence table not available	–
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	sequence table not available	–
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →