Gene detail

Detailed information of g605.t1 in Calvadosia cruxmelitensis

Genomic Location: not available for this species
NR annotation: XP_002165413.1, mitochondrial import inner membrane translocase subunit Tim22 [Hydra vulgaris]
Species Calvadosia cruxmelitensis · all data for this species · gene families

Sequence

Sequence data are not available for Calvadosia cruxmelitensis.
Nucleotide and protein sequences are provided for the species whose genome annotation is complete (see annotated genomes); for this species only the assembly is archived. The functional annotation below is likewise unavailable.

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5U4U5	Mitochondrial import inner membrane translocase subunit Tim22 OS=Xenopus laevis OX=8355 GN=timm22 PE=2 SV=1
Q9JKW1	Mitochondrial import inner membrane translocase subunit Tim22 OS=Rattus norvegicus OX=10116 GN=Timm22 PE=2 SV=2
Q5M7K0	Mitochondrial import inner membrane translocase subunit Tim22 OS=Xenopus tropicalis OX=8364 GN=timm22 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000001 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000047 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0000549 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0001440 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0003041 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0007522 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0009102 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0022293 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0022449 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0030293 (this species only) · gene tree & orthology
Orthogroup (gene family)	OG0042539 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02466 all species →	Tim17	Tim17/Tim22/Tim23/Pmp24 family	Family	Interproscan
PF00520 all species →	Ion_trans	Ion transport protein	Family	Interproscan
PF00078 all species →	RVT_1	Reverse transcriptase (RNA-dependent DNA polymerase)	Domain	Interproscan
PF17919 all species →	RT_RNaseH_2	RNase H-like domain found in reverse transcriptase	Domain	Interproscan
PF21672 all species →	COMM_HN	COMMD protein HN domain	Domain	Interproscan
PF07258 all species →	COMM_domain	COMM domain	Domain	Interproscan
PF13843 all species →	DDE_Tnp_1_7	Transposase IS4	Domain	Interproscan
PF03006 all species →	HlyIII	Haemolysin-III related	Family	Interproscan
PF07974 all species →	EGF_2	EGF-like domain	Domain	Interproscan
PF00754 all species →	F5_F8_type_C	F5/8 type C domain	Domain	Interproscan
PF00090 all species →	TSP_1	Thrombospondin type 1 domain	Domain	Interproscan
PF08516 all species →	ADAM_CR	ADAM cysteine-rich	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR039175 all species →	Family	Mitochondrial import inner membrane translocase subunit TIM22	Interproscan
IPR005821 all species →	Domain	Ion transport domain	Interproscan
IPR027359 all species →	Homologous_superfamily	Voltage-dependent channel domain superfamily	Interproscan
IPR011992 all species →	Homologous_superfamily	EF-hand domain pair	Interproscan
IPR000477 all species →	Domain	Reverse transcriptase domain	Interproscan
IPR043128 all species →	Homologous_superfamily	Reverse transcriptase/Diguanylate cyclase domain	Interproscan
IPR041577 all species →	Domain	Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain	Interproscan
IPR050951 all species →	Family	Retrovirus-related Pol polyprotein	Interproscan
IPR043502 all species →	Homologous_superfamily	DNA/RNA polymerase superfamily	Interproscan
IPR017920 all species →	Domain	COMM domain	Interproscan
IPR047155 all species →	Family	COMM domain-containing protein 4/6/7/8	Interproscan
IPR029526 all species →	Domain	PiggyBac transposable element-derived protein	Interproscan
IPR004254 all species →	Family	AdipoR/Haemolysin-III-related	Interproscan
IPR013111 all species →	Domain	EGF-like domain, extracellular	Interproscan
IPR036056 all species →	Homologous_superfamily	Fibrinogen-like, C-terminal	Interproscan
IPR036383 all species →	Homologous_superfamily	Thrombospondin type-1 (TSP1) repeat superfamily	Interproscan
IPR000884 all species →	Repeat	Thrombospondin type-1 (TSP1) repeat	Interproscan
IPR000742 all species →	Domain	EGF-like domain	Interproscan
IPR014716 all species →	Homologous_superfamily	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Interproscan
IPR000421 all species →	Domain	Coagulation factor 5/8 C-terminal domain	Interproscan
IPR006586 all species →	Domain	ADAM, cysteine-rich domain	Interproscan
IPR008979 all species →	Homologous_superfamily	Galactose-binding-like domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR14110 all species →	MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22	Interproscan
PTHR46726 all species →	TWO PORE CHANNEL 3	Interproscan
PTHR37984 all species →	PROTEIN CBG26694	Interproscan
PTHR16231 all species →	COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER	Interproscan
PTHR46599 all species →	PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4	Interproscan
PTHR20855 all species →	ADIPOR/PROGESTIN RECEPTOR-RELATED	Interproscan
PTHR19446 all species →	REVERSE TRANSCRIPTASES	Interproscan
PTHR16146 all species →	INTELECTIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0008320 all species →	Molecular Function	protein transmembrane transporter activity	Interproscan
GO:0030943 all species →	Molecular Function	mitochondrion targeting sequence binding	Interproscan
GO:0042721 all species →	Cellular Component	TIM22 mitochondrial import inner membrane insertion complex	Interproscan
GO:0045039 all species →	Biological Process	protein insertion into mitochondrial inner membrane	Interproscan
GO:0005216 all species →	Molecular Function	monoatomic ion channel activity	Interproscan
GO:0006811 all species →	Biological Process	monoatomic ion transport	Interproscan
GO:0016020 all species →	Cellular Component	membrane	Interproscan
GO:0055085 all species →	Biological Process	transmembrane transport	Interproscan
GO:0032088 all species →	Biological Process	negative regulation of NF-kappaB transcription factor activity	Interproscan
GO:0033209 all species →	Biological Process	tumor necrosis factor-mediated signaling pathway	Interproscan
GO:0045892 all species →	Biological Process	negative regulation of DNA-templated transcription	Interproscan
GO:0051059 all species →	Molecular Function	NF-kappaB binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0033211 all species →	Biological Process	adiponectin-activated signaling pathway	Interproscan
GO:0038023 all species →	Molecular Function	signaling receptor activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K07297	ADIPOR; adiponectin receptor	-	Non-alcoholic fatty liver disease	ko04932	deepkoala
K16897	TPCN3; two pore calcium channel protein 3	-	Ion channels	ko04040	deepkoala
K17790	TIM22; mitochondrial import inner membrane translocase subunit TIM22	-	Transporters	ko02000	deepkoala
K22562	COMMD6; COMM domain containing 6	-	Ubiquitin system	ko04121	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Calvadosia cruxmelitensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Calvadosia cruxmelitensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	sequence table not available	–
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	sequence table not available	–
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →