Genomic Location: chr1:40158084...40174606
NR annotation: XP_031572435.1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 [Actinia tenebrosa]
Species Actinoscyphia liui · all data for this species · gene families
| CDS |
| gene02653.t1 |
| Transcript |
| gene02653.t1 |
| Protein |
| gene02653.t1 |
| UniProt accession | Description |
|---|---|
| Q8IZJ3 | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CPAMD8 PE=1 SV=2 |
| P01023 | Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3 |
| Q5R4N8 | Alpha-2-macroglobulin OS=Pongo abelii OX=9601 GN=A2M PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000509 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF01835 all species → | MG2 | MG2 domain | Domain | Interproscan |
| PF17789 all species → | MG4 | Macroglobulin domain MG4 | Domain | Interproscan |
| PF07703 all species → | A2M_BRD | Alpha-2-macroglobulin bait region domain | Domain | Interproscan |
| PF07678 all species → | TED_complement | A-macroglobulin TED domain | Repeat | Interproscan |
| PF00207 all species → | A2M | Alpha-2-macroglobulin family | Family | Interproscan |
| PF07677 all species → | A2M_recep | A-macroglobulin receptor binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR002890 all species → | Domain | Macroglobulin domain | Interproscan |
| IPR040839 all species → | Domain | Macroglobulin domain MG4 | Interproscan |
| IPR050473 all species → | Family | Alpha-2-macroglobulin/Complement system | Interproscan |
| IPR013783 all species → | Homologous_superfamily | Immunoglobulin-like fold | Interproscan |
| IPR011625 all species → | Domain | Alpha-2-macroglobulin, bait region domain | Interproscan |
| IPR009048 all species → | Domain | Alpha-macroglobulin, receptor-binding | Interproscan |
| IPR036595 all species → | Homologous_superfamily | Alpha-macroglobulin, receptor-binding domain superfamily | Interproscan |
| IPR011626 all species → | Domain | Alpha-macroglobulin-like, TED domain | Interproscan |
| IPR019742 all species → | Conserved_site | Alpha-2-macroglobulin, conserved site | Interproscan |
| IPR041813 all species → | Domain | Alpha-2-macroglobulin, TED domain | Interproscan |
| IPR047565 all species → | Conserved_site | Alpha-macroglobulin-like, thiol-ester bond-forming region | Interproscan |
| IPR001599 all species → | Domain | Alpha-2-macroglobulin | Interproscan |
| IPR014756 all species → | Homologous_superfamily | Immunoglobulin E-set | Interproscan |
| IPR008930 all species → | Homologous_superfamily | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11412 all species → | MACROGLOBULIN / COMPLEMENT | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004866 all species → | Molecular Function | endopeptidase inhibitor activity | Interproscan |
| GO:0005576 all species → | Cellular Component | extracellular region | Interproscan |
| GO:0005615 all species → | Cellular Component | extracellular space | Interproscan |
gene02653.t1.Genes whose expression across the transcriptome samples of Actinoscyphia liui tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Actinoscyphia liui, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |