Gene detail

Detailed information of gene19252.t3 in Actinoscyphia liui

Genomic Location: chr5:29918887...29939986
NR annotation: XP_020908509.1, regulator of G-protein signaling 12 isoform X1 [Exaiptasia diaphana]
Species Actinoscyphia liui · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

gene19252.t3

ATGTCCATTGATGTACGGACTGTAGATTTGTGCCGTGGTCCTGGAGGATTTGGCTTCACGCTTTCAAGCCAAAGTCCCTGTGTACTCAGCTGTATTTTAGCTAGCAGCCCTGCTCATAAAGCTGGCCTCAAACCAGGCGATCAGATATTGTATGTGAATGGGAGTTCAGTGGAGAAATCGCCTCACGAACTGGTCGTCAAGTTGATTGCTCGTTCGCCTAATGGGATCGTAAACCTTGGGGTAAAGAATCGTGCTGCTTTATTGACTGGTTCTACGACCGCAGATAAACCAGAAACTCATGATCCTAGCGACAAGGACACTGTAAATGATCAAATCCTCAATCGTGTAGATAAAGTAGTGGAAGAGTTGAAATCTGGGCATCTATCTATCAGCAAACAGATTCCACTGCGCAGTAATAATGAGCAAGTTGAAATAGACGAAGATGAAATTGTAAGCGACGAAGAACTCAAAGCTTCTTTTACAGAAACTCTACGATCTGAGAGTTCTTCAGATAATGTATTTGTGGATAAAAATCATATCAGTAATCGGCGGGCTAGTGAAGGAGATGTACAGCCTGGACATCCTACACACAATTTAAACCGACTCCTCTATCCTGTCCTGACTCCGATAAAACCCGACAAAAACACACACTCCGAGAGAGCTAATTCTGAAGCCGATTTGAGAGCGATTGTTGGGTACCTAGGATCCATTGAACTCCCTGGGAATTCTAGTTTACAAACAGCAAGTTTACATGCAATTCGAAGCTGCGTTCGACGTCTTCGTGCACAACAGAAGGTCCATGTAATATTTTTGTTAGAGATTTCGTGCCTTGGGATACAGCTGGTAGATAAACATGGGAAACGAATAGTTACATATCCTATTAAGTCTCTAGCATTTACAGGCGTGTGTTCCGATGATAAAAGAGTATTTGGTATTGTTACAAAAAAAGCGAACGAAGGAAATCGTCCCAGCAGCTGGCACGAAAAAATGGATATTTCTGGTAGTACCGTCAATTGCTCATGTCACGTATTTACTGTGGACCCAGAAATCTCATTACACGAAGATCACCATTCGATTGCTGAGAAATTTCACATTAACTGTGCTACTGTGAATGGAAACTGTAAGGAATTCCTAGATTCTTCTTCTCCAATTTTACAGGCTATTAATGAGCTTTTTAAGGAAAGAACTGAATCTCAGTCATTTTCTTCCAGCCAGTCCGAAAATAATGAAATGGAAAGTGGAAAAATACCCCCAGATACTGAAGAGGGCAATAACCCAGGAAATGGACACCCAGATCATGCCCAAGATGCACAGTCAGAGCTTCTGCATAATCACGTGCAGGAAGAAAGTATTACTCCAAATGAAGTAATAAATGAATGTGTTATGGAAACCCCAAAACACAGGATTCATGTGAAAGTTACAGACTATCGCGAATCAACTAATACTAGTACTGTTCAAATATCATCTATTGAAGAGCCATGTAAGAGACGTAGAGTGCTGCAAATTGAGCGAGTTGCCGTGTTCCCCCCTGGTAAAACAAATGGGATTGTAAAAGAACAAGTTACTTCTAGTGAAACAACAGATCTAGATAGTACTGGTGATGGTGATATGGACAATGGAAGGAAGGAAGGTCAAGCAGTAGATCTCAACCAGGCTGGACCCAATGTCTCTGATACTCCCTCTCCAGATTCACAGCTGGCATCACATAACAATAAAGATACCAGCCAAGATTTAAAGATAAATCATTTCCCATTTAATTCTACTTTACGTTTGAGCCACTCTGCTGAGAATCTGTCTCACAATGACTATGATACAGTTGTCTCCAGTAGCTCAAATCTCAATGTCAGCCCAAGTGTATGTTCCAGTACCCAGAGTGTACATAGTCTGGGGAGTATTGCTGGGGAGTTGTCAAGTATTCAAGGACGTGTGGCTCAGTGGTCTCTTGGATTTGATAAACTTATTGAGGATCCCATCGGCTTGAAATGTTTTCAGGAATTTCTTAAGAAAGAGTTCAGCGAGGAGAATATTATGTTTTGGATGGCATGCGAAGAGTTTAGAAATATCACCACTGAAAAAGAGCTCAAAGCAGCAGCCATCAGCATATTTGATGCTCATCTCAGCCCTCATGCAACAATGCCTGTGAATATTGATAGTTCTGCTATTAAACTTGCCGAAGAACATTTTGCGAACCCAACAAATGATATGTATAGACTGCAACAACAACAGGTGTACACTTTAATGAAGTTTGACAGTTATCCAAGATTCTTAAAGTCAGACATGTACAGACAATGTCTTGTAGCTGATATAGAAGGACTTACTCTACCATTTGATGATGGCAAACCTGACAAAGGAAAACTCTCTAAAAAGGGCAACTGCTTGTCACTATCTTCAGAGGACTCAGAATGTTCCAGTGTAAGCAGTCGAGGGAGCTACACTTTTGAAATCAAGCGTTCAACGCGTGGCTGGGGAAGACGAAGCAGTAAAAAGAGTTCAAGTTCTTATGATGAAACAGGAGAGAAGAAAAAATCCTTTCTTCCATGGAAAGGAAAGCAACCTAAGAAAGGAGGAGCCACTCGTCCATTTGACAGTCAACCCAGCAGTACCCGCAGCTCATTGTCGTCTTTATCTGATTCCTTCCCAAGCATAAGTTATTCAACCGAGTCTCTAGAGGTCCGACGTGAAAGCGATTCGTTCCAGTTCTGTCGTGTAGTTCTACCGGACCATTCATCCACCATTATTACTTCCAAACAAGGACAGACGTTACGACAGGCTTTAGCACAGCTTTGTGAGAGACGACATATGTCTCTCGTTGCTACGGAGGTCTTTATTTGTGGCTCGGATAGGCCTGCACAGTACAAAGAACTCGACGCTGACATGTCTGGTATGGCTGGCAAGGAGATCAACTTGGAACACAGAACGCTATTCAGAGTTGAGCTTTCTAAAGGAAACTTAGTACTGGTGAAGGCCAGACCAGACCAGTCGATACGCGATAGTATTGAACCCATATTAATACGATATGACATGGAATACTCTAACGTCGTTGTACACTTGGTGGGCTGTGAAGTACCTTTGGACAGCGGTATTCCAGTAGCCTCGATCGAACATCAATGTGTTGTCATAGAAACCAATGATCAGCTGACTGGTCGATCGGTGGCTCAGTTGCGTGGGGTGAGGCGTGTACTCTTCTATAGTTCATTCAGGGACGCGATGTTAAAGTTTGCCGTCTACGGCAATAACAATGGCCCACCAAAGATCAACATCAAGCCTCCAGTGGGGTTCAGTTCTCCTCGGCGCAGTAGCAGGCGAGGTAGCAGCATCGATGACTCGATCTTCGAAGATATCATACGCGGACGGAAACAGTCGCTAGGCAACGGTTACTTTGACGACGCAGGTATCTGGATACCCGGATTAAAGCCGTTTCGAAGCCAAGAGTCCTTGAATGATGATAGTTTTGGTAGGAGCTTTCTTCGAGGTCCAGGGTTGTTCGGCAGGAAGAGGAAAGAATCCAACGAGAAGTCTTTGAACAAGTCAGTCCGTGAGGGAAAGCAGGCAAATATCAAGAATAATTTAGAAGTTACAGAGTTATTAGACCTCTTAAGCCGCGCCCAAGGGAACAGAATGGACGACCAAAGAGGGGAACTCGGTAAACACAGCTTTGAATTACCTGATTTCTTGCGTTTACCGCAAGCTGGACCAACGAGACAAACAGAGAACAAAACTGCCCCACCCCCACCCCCACCACCACCTGTAGGATCATCGTTACGTCATACCACAGGGAGCCTGAAACTGAAGGGTGAAACACGACCCGTTGTTAGAAAGGCTTTATCGTCTCCATCTAACGGTAAAGACGACTTAATGTCTGAACTAGCAGACAAGCTACGACGTAGATCGACATCAGAGACCATGTCGATACCCGAGACTCGTGAGACTGAGGACAGCGTTGAGGGTCTGGTGAAGCGATCTGACTCAACCTCTAGTAAGGAACGATCTTATTCCCCCTGGGAACCCAGGTATCCTAGTGAACATTACCGACGGATCAATATAGTCCGACCCAAGACCTGTACTGACGGTGCTGTATTCACGGTCGAGGCAGTAACGCCCGTTCGATTGGACAGGGCGTTGAGTCCATCTGGAGTACCTATATCGCACTCTGAGAGTATGCCCGATGTGGTACAGACACGTACACGCGGTACCCAACCATTAACTGTGAATTCTATACGTGGGTTACCTACGTCTACTGGTAACGTCAATCGAACAGACGAACAACATGAACCAGAGAAAATCGTAAGAGTGGTCCAAGCTTTTCCAGTTCAGAAATACCAAACGTACGCAGCCAAGCCCAGAACGCTATCATCGTCCAGCGCGCCTGACTATTCACGCAACATGCCTTACGTTTACGAAGCAACGCCGAGTGAAAAACGAGAGAAATTGAAATCATCTTCCTTGAAAAGACGCCAAAGTGATGGCACAACGACAGGCACTAAAGGGAATCTTTCTCCGTTTCACTTCCCTCAACTTAACGCCAGAAAAACAGAAATATTTGTACCAGCGACTCCTGGCATCAAGCCCTATCGTATTATAAGTTCAGAATCGAAGCCACGGCCCAAACCTATCACACACTCTGCAGAGTTAATGGCAGGTCTTGAGGAAGATAGTAACGTAGTGGTAGATGATGTACCTCCCATTGTGCCACCGCCTCCACCTGAACTGATACACCCTTCCACCACAGCACCTAGGATAACATCTCCTGTAGTGTCTGATAGGAAGATCACTAGTCCCCTACCCCTACCCCCTTCACCAGTACCTGAAAACGTCGTAGACTTGGACATCGCTAACTTCCCTCCGCCTACTCCGCTCTATGATGCCGATTCAAAGAAAGGGGTCGATTCTACACCCATTGCCACACCCAACTTCAATCTTAGCAACGATATGACAATCACACCCGCGACTAATGACAAGACTGTTGTTTTTGATTCACCTGATGATGGAACGCCTTACGCACCACCGAAAGATTCTAGAAGAGATAATCAGAGACTTGGTTCCAGACTCTTTGATGAATCGCAGGCGTCAAGTTCGAGGAAGCCTGTGAAAGAATTTCCTAAACTTGATCCTTACGTAACGTATGAGAGCGATGACATGAGAATCACCTTCGTTTAG

Transcript

gene19252.t3

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O14924	Regulator of G-protein signaling 12 OS=Homo sapiens OX=9606 GN=RGS12 PE=1 SV=1
Q8CGE9	Regulator of G-protein signaling 12 OS=Mus musculus OX=10090 GN=Rgs12 PE=1 SV=2
O08774	Regulator of G-protein signaling 12 OS=Rattus norvegicus OX=10116 GN=Rgs12 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002678 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00595 all species →	PDZ	PDZ domain	Domain	Interproscan
PF02188 all species →	GoLoco	GoLoco motif	Motif	Interproscan
PF00640 all species →	PID	Phosphotyrosine interaction domain (PTB/PID)	Domain	Interproscan
PF02196 all species →	RBD	Raf-like Ras-binding domain	Domain	Interproscan
PF00615 all species →	RGS	Regulator of G protein signaling domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001478 all species →	Domain	PDZ domain	Interproscan
IPR006020 all species →	Domain	PTB/PI domain	Interproscan
IPR029071 all species →	Homologous_superfamily	Ubiquitin-like domain superfamily	Interproscan
IPR003116 all species →	Domain	Raf-like Ras-binding	Interproscan
IPR016137 all species →	Domain	RGS domain	Interproscan
IPR036034 all species →	Homologous_superfamily	PDZ superfamily	Interproscan
IPR036305 all species →	Homologous_superfamily	RGS domain superfamily	Interproscan
IPR046995 all species →	Family	Regulator of G-protein signaling 10/12/14-like	Interproscan
IPR003109 all species →	Conserved_site	GoLoco motif	Interproscan
IPR024066 all species →	Homologous_superfamily	RGS, subdomain 1/3	Interproscan
IPR044926 all species →	Homologous_superfamily	RGS, subdomain 2	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR45945 all species →	REGULATOR OF G-PROTEIN SIGNALING LOCO	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0007165 all species →	Biological Process	signal transduction	Interproscan
GO:0005096 all species →	Molecular Function	GTPase activator activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0008277 all species →	Biological Process	regulation of G protein-coupled receptor signaling pathway	Interproscan
GO:0030695 all species →	Molecular Function	GTPase regulator activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

No KEGG orthology assignment for gene19252.t3.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Actinoscyphia liui tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Actinoscyphia liui, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →