Gene detail

Detailed information of gene20745.t1 in Actinoscyphia liui

Genomic Location: chr5:52314017...52363743
NR annotation: XP_020893559.1, probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [Exaiptasia diaphana]
Species Actinoscyphia liui · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

gene20745.t1

ATGCCTACTCGTGTCGTGTCTATTGACCGTACCAATGTCGCAATGCTGATGTTAACTAGGTTCAGAAATGCAAGATGTTTACCGAATAGATTTAAAGTAGCAAGCTATCATGCTGACAAAGGCTGTTTTGGTTTTCGTCCTAAAGAGAAAATCGTTTTTGAAGAAGGAAAAGCTGGGCAAAGAAACAGAATATATCATTCCAATCTCTTTAGACTGATCACAGCATATAGAAAACATGGACATAAGAAAGCTAATTTTAATCCTTTAGCAAATGTTGCAAGAACAAATATAGAAAATGTTGAAGTAACAGAACTCAATCTAGACCAGTATGGACTTGAGAATACTGACCTAAATACCACAGTGAAACTTGCAGGTTTAATTCACTTAGAAGACAAACAAGAAGCAAGTTATAAAGCAATCTTAGATCAGCTAGAACGGGTATACTGTGGAGAGTTATCTGTGGAATTACATCATCTTCAGAATGAACAAGAAAAGCTGTGGTTTTCTAACCTTGTTGAAGAGAGTATACACTGGTACTTAGACAGCGTGAGACAAAAACATTTGGCAAAGCTTTTATTGAGATCTCAGGCATTTGACAACTTTGTGGCAAAGAAATTCATTACAGTAAAGACGTATAGTGCTGAAGGGGCTGAGAGTATGCTGGTGTTCTTTGATGAACTTCTTCTTCAAGCCTCAAATGATGGCTTTGAGCAAGTAGTGATAGGAATGCCACACAGAGGAAGACTGAACCTGTTAACAGGCTTGCTAAAGTATCCAGCACCTTTGATGTTCTCCAAGATGATGGGAAACTCTGAATTATATCCTGGAGCACCAACAAGTGGTGATGTATTGTCTCATTTGAGAAATTCTGTTGACCTTGACCTTGGTGGACAGAGTCCCCTGCACGTTACCATGGTACCCAATCCATCTCATCTAGAAGCTGGTTGTCCTGTAGCCATTGGTAAAGCAAGAGGAAAACAAATGTCTAAAGAATGGGGTGACTACAGTAAAACGGGAGATAAAGACAAGGTCATGTGTGTTTTAGTGCATGGGGATGCATCTTTTATTGCACAGGGTATTATTGCTGAGACCCTCTGCATGTCAGGATTACCTCATTATAAAATTGGTGGTACAATACACTTGATTGTTAACAACCAATTAGGATTTACAACACCTGCAGACAAAGCTAGGTCATCTCTGTATGCTAGTGACATTGCTAAGATGATTGACTGTCCAGTTATTCACGTTAATGGTGACTACCCTGAGGAGGTATTGAGAGCATCACAACTGGCTATAGATTATCGAAGGAAGTTCAATAAAGATATCGTTGTAGATATGAACTGCTATAGACGACTGGGCCATAACGAGATAGATGACCCTACGTTTACCCAACCATCCATGTATAATGTAATCAAGCATCATCAAAGTGCGCCTGATAGGTACGCAATGCAGTTAGAGCAAATGGGCGTGGTAACGCATGATGCCCTCGTGGAGGATGTGGCTGGTTACAATGTAATGTTAAATCAGGATTTCAAAAAAGCAGAGAAATATGAACCTGTACCTACTCACCTTGAGTCCTGCTGGTCAGGCATGGTGGAAGCCAGTGTTGATAAAATTACTTCTTGGGAAACAGGTCTGCCCCTGGACACTCTCCTCTACGTGGGTTCAAAATCCGTTGGGCTACCATCCAACTTTAACATTCATCCACATCTCAAAAAGACGCACATTAAGGCGAGGCTTGAGAAACTCAAAGTGGGTACTGCTATTGACTGGGCAACAGCTGAAGCTCTGGCTTTGGGAACCTTGCTGTTCCAAGGCTATAATGCTCGAATAAGTGGCCAGGATGTGGGAAGGGGAACTTTCAGTCATAGACATGCCATGCTTGTCGACCAGAAGACCGACGAGATTTTCATTCCACTGAATAACATCCAAGAAAACCAAACTGGATTTCTCGAGATCTGTAACAGCCATCTGTCCGAAGAAGCCGTTTTAGGTTTCGAGTATGGCATGAGTATCGAGAACCCAAACAATCTGATTATTTGGGAGGCACAATTTGGAGACTTCTTCAATGGTGCTCAGATAATTATCGACACTTACATAGGATCTGGTGAAACCAAATGGTTACTTCATAATGGACTTGTTATGCTTTTACCTCACGGATACGATGGTGCGGGACCAGAACACTCATCTTGTCGTATCGAGAGATTTCTACAGATGACCGACAGTAAAGAAGATGGTATGGATGGTGACAGCGTTAATATGCACATCGTGAACCCAACAACACCAGCACAGTATTTCCATCTCCTTAGACAACAGATGATCCGTAATTTTAGAAAACCTTTAATCGTGGCATCACCAAAGTTACTTCTTCGATTACCGACTGCCACGTCGTCCCTTGAAGAGATGGGTCCTGAGACGTATTTTCATCCTGTGATTGGAGACCCGCTCATTAAGGGACCAGATGTCCGCCGTATCGTTTTTTGCTCTGGGAAACACTACTATGCTCTGGCAAAGAAGCGACATGAATTAGGTGCCCTTGACACAGCAATTATTAGACTTGAGGCGTTAACACCATTTCCTGCTGACTTGCTTAAAAGAGAAATTAAAAGATACCCCTCTGCTAAAGAGTTCATTTGGAGCCAAGAAGAGCACAGGAACATGGGGGTCTGGTCCTTTGTCTCTCCAAGATTTGAGAATGTACTTGGGTTAAAACTAAAATACGTCGGTCGAAAAGTTCTCGCGGCTCCTGCCGTTGCAATCGGTAAACTTCACACTCAAGAATCCTATGACGTGTTACATGATACATTCTCACACTGA

Transcript

gene20745.t1

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5R7H0	2-oxoadipate dehydrogenase complex component E1 OS=Pongo abelii OX=9601 GN=DHTKD1 PE=2 SV=1
Q96HY7	2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2
Q4KLP0	2-oxoadipate dehydrogenase complex component E1 OS=Rattus norvegicus OX=10116 GN=Dhtkd1 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001267 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00676 all species →	E1_dh	Dehydrogenase E1 component	Family	Interproscan
PF02779 all species →	Transket_pyr	Transketolase, pyrimidine binding domain	Domain	Interproscan
PF16870 all species →	OxoGdeHyase_C	2-oxoglutarate dehydrogenase C-terminal	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001017 all species →	Domain	Dehydrogenase, E1 component	Interproscan
IPR005475 all species →	Domain	Transketolase-like, pyrimidine-binding domain	Interproscan
IPR011603 all species →	Family	2-oxoglutarate dehydrogenase E1 component	Interproscan
IPR042179 all species →	Homologous_superfamily	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily	Interproscan
IPR031717 all species →	Domain	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal	Interproscan
IPR029061 all species →	Homologous_superfamily	Thiamin diphosphate-binding fold	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR23152 all species →	2-OXOGLUTARATE DEHYDROGENASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0016624 all species →	Molecular Function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Interproscan
GO:0030976 all species →	Molecular Function	thiamine pyrophosphate binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K15791	DHKTD1; 2-oxoadipate dehydrogenase E1 component	EC:1.2.4.-	Mitochondrial biogenesis	ko03029	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Actinoscyphia liui tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Actinoscyphia liui, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →