Genomic Location: Sc0000067:15989...35644
NR annotation: XP_029204020.2, ubiquitin conjugation factor E4 A-like isoform X2 [Acropora millepora]
Species Galaxea fascicularis · all data for this species · gene families
| CDS |
| gfas1.m1.2004.m1 |
| Transcript |
| gfas1.m1.2004.m1 |
| Protein |
| gfas1.m1.2004.m1 |
| UniProt accession | Description |
|---|---|
| Q6P7A2 | Ubiquitin conjugation factor E4 A OS=Rattus norvegicus OX=10116 GN=Ube4a PE=2 SV=1 |
| Q14139 | Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2 |
| A5PKG6 | Ubiquitin conjugation factor E4 A OS=Bos taurus OX=9913 GN=UBE4A PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003384 (this species only) · gene tree & orthology |
| Ubiquitin family | E3|E3 activity RING|U-box · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF10408 all species → | Ufd2P_core | Ubiquitin elongating factor core | Family | Interproscan |
| PF04564 all species → | U-box | U-box domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR013083 all species → | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | Interproscan |
| IPR045132 all species → | Family | Ubiquitin conjugation factor E4 | Interproscan |
| IPR019474 all species → | Domain | Ubiquitin conjugation factor E4, core | Interproscan |
| IPR003613 all species → | Domain | U-box domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR13931 all species → | UBIQUITINATION FACTOR E4 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000151 all species → | Cellular Component | ubiquitin ligase complex | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0030433 all species → | Biological Process | obsolete ubiquitin-dependent ERAD pathway | Interproscan |
| GO:0034450 all species → | Molecular Function | ubiquitin-ubiquitin ligase activity | Interproscan |
| GO:0036503 all species → | Biological Process | ERAD pathway | Interproscan |
| GO:0006511 all species → | Biological Process | ubiquitin-dependent protein catabolic process | Interproscan |
| GO:0016567 all species → | Biological Process | protein ubiquitination | Interproscan |
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10596 | UBE4A; ubiquitin conjugation factor E4 A | EC:2.3.2.27 | Ubiquitin system | ko04121 | deepkoala |
Transcript abundance of gfas1.m1.2004.m1 across 22 RNA-seq samples of Galaxea fascicularis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| coral holosome · Control | 7 | 7 | 127.44 | 231.19 | |
| coral holosome · 30ic treatment | 6 | 6 | 110.84 | 186.71 | |
| coral holosome · Prometryn (herbicidess) treatment | 5 | 5 | 89.39 | 116.21 | |
| coral holosome · Prometryn (herbicidess) and 30ic treatment | 4 | 4 | 82.86 | 114.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27118485 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 231.19 |
| SRR27118486 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 138.42 |
| SRR27118487 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 133.68 |
| SRR27118488 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 115.09 |
| SRR27118480 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 98.51 |
| SRR27118492 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 97.49 |
| SRR27118491 | coral holosome · Control | coral holosome | not recorded | Control | SRP476288 | 77.66 |
| SRR27118468 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 186.71 |
| SRR27118466 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 112.51 |
| SRR27118477 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 100.02 |
| SRR27118476 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 91.11 |
| SRR27118479 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 88.84 |
| SRR27118478 | coral holosome · 30ic treatment | coral holosome | not recorded | 30ic treatment | SRP476288 | 85.84 |
| SRR27118483 | coral holosome · Prometryn (herbicidess) treatment | coral holosome | not recorded | Prometryn (herbicidess) treatment | SRP476288 | 116.21 |
| SRR27118484 | coral holosome · Prometryn (herbicidess) treatment | coral holosome | not recorded | Prometryn (herbicidess) treatment | SRP476288 | 108.06 |
| SRR27118481 | coral holosome · Prometryn (herbicidess) treatment | coral holosome | not recorded | Prometryn (herbicidess) treatment | SRP476288 | 105.64 |
| SRR27118469 | coral holosome · Prometryn (herbicidess) treatment | coral holosome | not recorded | Prometryn (herbicidess) treatment | SRP476288 | 74.85 |
| SRR27118482 | coral holosome · Prometryn (herbicidess) treatment | coral holosome | not recorded | Prometryn (herbicidess) treatment | SRP476288 | 42.17 |
| SRR27118475 | coral holosome · Prometryn (herbicidess) and 30ic treatment | coral holosome | not recorded | Prometryn (herbicidess) and 30ic treatment | SRP476288 | 114.00 |
| SRR27118472 | coral holosome · Prometryn (herbicidess) and 30ic treatment | coral holosome | not recorded | Prometryn (herbicidess) and 30ic treatment | SRP476288 | 109.88 |
| SRR27118489 | coral holosome · Prometryn (herbicidess) and 30ic treatment | coral holosome | not recorded | Prometryn (herbicidess) and 30ic treatment | SRP476288 | 58.19 |
| SRR27118490 | coral holosome · Prometryn (herbicidess) and 30ic treatment | coral holosome | not recorded | Prometryn (herbicidess) and 30ic treatment | SRP476288 | 49.35 |
Source: CnidoSite RNA-seq expression matrices (GFASC_TPM,
StringTie quantification over 22 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Galaxea fascicularis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 18 | gfas1.m1.13407.m1 | 0.913549720192672 |
| Negatively correlated | 21 | gfas1.m1.7529.m1 | -0.799349379318966 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Galaxea fascicularis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |