Genomic Location: ctg_0060:265307...280609
NR annotation: XP_048582098.1, merlin [Nematostella vectensis]
Species Edwardsia elegans · all data for this species · gene families
| CDS |
| jg3606.t1 |
| Transcript |
| jg3606.t1 |
| Protein |
| jg3606.t1 |
| UniProt accession | Description |
|---|---|
| P35240 | Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1 |
| P59750 | Merlin OS=Papio anubis OX=9555 GN=NF2 PE=3 SV=1 |
| P46662 | Merlin OS=Mus musculus OX=10090 GN=Nf2 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001415 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF09379 all species → | FERM_N | FERM N-terminal domain | Domain | Interproscan |
| PF20492 all species → | ERM_helical | Ezrin/radixin/moesin, alpha-helical domain | Coiled-coil | Interproscan |
| PF00769 all species → | ERM_C | Ezrin/radixin/moesin family C terminal | Domain | Interproscan |
| PF09380 all species → | FERM_C | FERM C-terminal PH-like domain | Domain | Interproscan |
| PF00373 all species → | FERM_M | FERM central domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR011993 all species → | Homologous_superfamily | PH-like domain superfamily | Interproscan |
| IPR000798 all species → | Family | Ezrin/radixin/moesin-like | Interproscan |
| IPR041789 all species → | Domain | ERM family, FERM domain C-lobe | Interproscan |
| IPR014352 all species → | Homologous_superfamily | FERM/acyl-CoA-binding protein superfamily | Interproscan |
| IPR008954 all species → | Homologous_superfamily | Moesin tail domain superfamily | Interproscan |
| IPR018980 all species → | Domain | FERM, C-terminal PH-like domain | Interproscan |
| IPR018979 all species → | Domain | FERM, N-terminal | Interproscan |
| IPR019748 all species → | Domain | FERM central domain | Interproscan |
| IPR000299 all species → | Domain | FERM domain | Interproscan |
| IPR046810 all species → | Domain | Ezrin/radixin/moesin, alpha-helical domain | Interproscan |
| IPR011174 all species → | Family | Ezrin/radixin/moesin | Interproscan |
| IPR019749 all species → | Domain | Band 4.1 domain | Interproscan |
| IPR011259 all species → | Domain | Ezrin/radixin/moesin, C-terminal | Interproscan |
| IPR029071 all species → | Homologous_superfamily | Ubiquitin-like domain superfamily | Interproscan |
| IPR035963 all species → | Homologous_superfamily | FERM superfamily, second domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR23281 all species → | MERLIN/MOESIN/EZRIN/RADIXIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0008092 all species → | Molecular Function | cytoskeletal protein binding | Interproscan |
| GO:0003779 all species → | Molecular Function | actin binding | Interproscan |
| GO:0005856 all species → | Cellular Component | cytoskeleton | Interproscan |
| GO:0005178 all species → | Molecular Function | integrin binding | Interproscan |
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0005912 all species → | Cellular Component | adherens junction | Interproscan |
| GO:0008285 all species → | Biological Process | negative regulation of cell population proliferation | Interproscan |
| GO:0008360 all species → | Biological Process | regulation of cell shape | Interproscan |
| GO:0030175 all species → | Cellular Component | filopodium | Interproscan |
| GO:0035330 all species → | Biological Process | regulation of hippo signaling | Interproscan |
| GO:0045177 all species → | Cellular Component | apical part of cell | Interproscan |
| GO:0050839 all species → | Molecular Function | cell adhesion molecule binding | Interproscan |
| GO:1902115 all species → | Biological Process | regulation of organelle assembly | Interproscan |
| GO:1902966 all species → | Biological Process | positive regulation of protein localization to early endosome | Interproscan |
| GO:2000643 all species → | Biological Process | positive regulation of early endosome to late endosome transport | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K16684 | NF2; merlin | - | Cytoskeleton proteins | ko04812 | deepkoala |
Genes whose expression across the transcriptome samples of Edwardsia elegans tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Edwardsia elegans, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |