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This orthogroup contains 193 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 193 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR23113 | GUANINE NUCLEOTIDE EXCHANGE FACTOR | 162 / 193 | 83.9% | 99.4% of 163 | ≥80% support |
| Pfam | PF00617 | RasGEF | 163 / 193 | 84.5% | 98.8% of 165 | ≥80% support |
| GO | GO:0005085 Molecular Function | guanyl-nucleotide exchange factor activity | 163 / 193 | 84.5% | 100.0% of 163 | ≥80% support |
| GO | GO:0007264 Biological Process | small GTPase-mediated signal transduction | 163 / 193 | 84.5% | 100.0% of 163 | ≥80% support |
| GO | GO:0005886 Cellular Component | plasma membrane | 162 / 193 | 83.9% | 99.4% of 163 | ≥80% support |
| GO | GO:0007265 Biological Process | Ras protein signal transduction | 162 / 193 | 83.9% | 99.4% of 163 | ≥80% support |
| GO | GO:0043547 Biological Process | positive regulation of GTPase activity | 162 / 193 | 83.9% | 99.4% of 163 | ≥80% support |
| Pfam | PF00618 | RasGEF_N — RasGEF N-terminal motif | 151 / 193 | 78.2% | 91.5% of 165 | ≥50% support |
| KEGG | K06277 | RAPGEF1, GRF2 — Renal cell carcinoma | 153 / 193 | 79.3% | 100.0% of 153 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Actinia mediterranea | ENSQPTP00000024087.1 | XP_031560568.1 | rap guanine nucleotide exchange factor 1-like [Actinia tenebrosa] | Q13905 Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX= | JBrowse |
| Actinia mediterranea | ENSQPTP00000066376.1 | XP_031560568.1 | rap guanine nucleotide exchange factor 1-like [Actinia tenebrosa] | Q13905 Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX= | JBrowse |
