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This orthogroup contains 219 genes from 140 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 219 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR12474 | P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| Pfam | PF04636 | PA26 | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:0016239 Biological Process | positive regulation of macroautophagy | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:0016684 Molecular Function | oxidoreductase activity, acting on peroxide as acceptor | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:0070728 Molecular Function | L-leucine binding | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:0071233 Biological Process | cellular response to L-leucine | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:1901031 Biological Process | regulation of response to reactive oxygen species | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:1904262 Biological Process | negative regulation of TORC1 signaling | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| GO | GO:1990253 Biological Process | cellular response to leucine starvation | 191 / 219 | 87.2% | 100.0% of 191 | ≥80% support |
| KEGG | K10141 | SESN1_3 — Longevity regulating pathway | 161 / 219 | 73.5% | 97.6% of 165 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Cyphastrea salae | ENSOFVP00000029564.1 | XP_020627359.1 | sestrin-1-like [Orbicella faveolata] | P58003 Sestrin-1 OS=Xenopus laevis OX=8355 GN=sesn1 PE=2 SV=1 | JBrowse |
| Cyphastrea salae | ENSOFVP00000029574.1 | XP_020627359.1 | sestrin-1-like [Orbicella faveolata] | P58003 Sestrin-1 OS=Xenopus laevis OX=8355 GN=sesn1 PE=2 SV=1 | JBrowse |
| Cyphastrea salae | ENSOFVP00000029587.1 | XP_020627359.1 | sestrin-1-like [Orbicella faveolata] | P58003 Sestrin-1 OS=Xenopus laevis OX=8355 GN=sesn1 PE=2 SV=1 | JBrowse |
