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This orthogroup contains 200 genes from 135 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 200 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR31457 | METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| Pfam | PF16690 | MMACHC — Methylmalonic aciduria and homocystinuria type C family | 177 / 200 | 88.5% | 100.0% of 177 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| GO | GO:0009235 Biological Process | cobalamin metabolic process | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| GO | GO:0032451 Molecular Function | demethylase activity | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| GO | GO:0033787 Molecular Function | cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| GO | GO:0071949 Molecular Function | FAD binding | 176 / 200 | 88.0% | 100.0% of 176 | ≥80% support |
| KEGG | K14618 | MMACHC — Cobalamin transport and metabolism | 171 / 200 | 85.5% | 100.0% of 171 | ≥80% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Cyphastrea salae | ENSOFVP00000013643.1 | XP_020601003.1 | methylmalonic aciduria and homocystinuria type C protein homolog [Orbicella faveolata] | Q5ZL21 Cyanocobalamin reductase / alkylcobalamin dealkylase OS=Gall | JBrowse |
