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This orthogroup contains 485 genes from 148 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 485 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR42737 | GLUTATHIONE REDUCTASE | 426 / 485 | 87.8% | 99.5% of 428 | ≥80% support |
| Pfam | PF07992 | Pyr_redox_2 — Pyridine nucleotide-disulphide oxidoreductase | 411 / 485 | 84.7% | 96.5% of 426 | ≥80% support |
| GO | GO:0050660 Molecular Function | flavin adenine dinucleotide binding | 428 / 485 | 88.3% | 99.8% of 429 | ≥80% support |
| GO | GO:0004362 Molecular Function | glutathione-disulfide reductase (NADPH) activity | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0005739 Cellular Component | mitochondrion | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0006749 Biological Process | glutathione metabolic process | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0016491 Molecular Function | oxidoreductase activity | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0034599 Biological Process | cellular response to oxidative stress | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| GO | GO:0045454 Biological Process | cell redox homeostasis | 426 / 485 | 87.8% | 99.3% of 429 | ≥80% support |
| Pfam | PF02852 | Pyr_redox_dim — Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | 380 / 485 | 78.4% | 89.2% of 426 | ≥50% support |
| GO | GO:0016668 Molecular Function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | 356 / 485 | 73.4% | 83.0% of 429 | ≥50% support |
| GO | GO:0004791 Molecular Function | thioredoxin-disulfide reductase (NADPH) activity | 317 / 485 | 65.4% | 73.9% of 429 | ≥50% support |
| KEGG | K22182 | TXNRD — Hepatocellular carcinoma | 335 / 485 | 69.1% | 97.1% of 345 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Desmophyllum pertusum | KAJ7325621.1 | KAJ7325621.1 | Thioredoxin reductase 2, mitochondrial [Desmophyllum pertusum] | Q9NNW7 Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=96 | JBrowse |
| Desmophyllum pertusum | KAJ7325622.1 | KAJ7325622.1 | Thioredoxin reductase 2, mitochondrial [Desmophyllum pertusum] | Q9NNW7 Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=96 | JBrowse |
| Desmophyllum pertusum | KAJ7353844.1 | KAJ7353844.1 | thioredoxin reductase [Desmophyllum pertusum] | Q99MD6 Thioredoxin reductase 3 OS=Mus musculus OX=10090 GN=Txnrd3 P | JBrowse |
