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This orthogroup contains 375 genes from 144 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 375 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10063 | TUBERIN | 319 / 375 | 85.1% | 99.1% of 322 | ≥80% support |
| GO | GO:0005096 Molecular Function | GTPase activator activity | 324 / 375 | 86.4% | 99.4% of 326 | ≥80% support |
| GO | GO:0043547 Biological Process | positive regulation of GTPase activity | 324 / 375 | 86.4% | 99.4% of 326 | ≥80% support |
| GO | GO:0032007 Biological Process | negative regulation of TOR signaling | 321 / 375 | 85.6% | 98.5% of 326 | ≥80% support |
| GO | GO:0033596 Cellular Component | TSC1-TSC2 complex | 321 / 375 | 85.6% | 98.5% of 326 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 320 / 375 | 85.3% | 98.2% of 326 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 319 / 375 | 85.1% | 97.9% of 326 | ≥80% support |
| Pfam | PF11864 | DUF3384 | 236 / 375 | 62.9% | 72.6% of 325 | ≥50% support |
| Pfam | PF02145 | Rap_GAP — Rap/ran-GAP | 234 / 375 | 62.4% | 72.0% of 325 | ≥50% support |
| Pfam | PF03542 | Tuberin | 234 / 375 | 62.4% | 72.0% of 325 | ≥50% support |
| GO | GO:0051056 Biological Process | regulation of small GTPase mediated signal transduction | 240 / 375 | 64.0% | 73.6% of 326 | ≥50% support |
| GO | GO:0030178 Biological Process | negative regulation of Wnt signaling pathway | 221 / 375 | 58.9% | 67.8% of 326 | ≥50% support |
| GO | GO:0046627 Biological Process | negative regulation of insulin receptor signaling pathway | 221 / 375 | 58.9% | 67.8% of 326 | ≥50% support |
| GO | GO:0051726 Biological Process | regulation of cell cycle | 221 / 375 | 58.9% | 67.8% of 326 | ≥50% support |
| GO | GO:0051898 Biological Process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 221 / 375 | 58.9% | 67.8% of 326 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Desmophyllum pertusum | KAJ7372751.1 | KAJ7372751.1 | Tuberous sclerosis 2-like protein [Desmophyllum pertusum] | P49815 Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2 | JBrowse |
| Desmophyllum pertusum | KAJ7372777.1 | KAJ7372777.1 | Tuberous sclerosis 2-like protein [Desmophyllum pertusum] | P49815 Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2 | JBrowse |
| Desmophyllum pertusum | KAJ7372778.1 | KAJ7372778.1 | Tuberous sclerosis 2-like protein, partial [Desmophyllum pertusum] | Q61037 Tuberin OS=Mus musculus OX=10090 GN=Tsc2 PE=1 SV=1 | JBrowse |
