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This orthogroup contains 248 genes from 133 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 248 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10073 | DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL | 193 / 248 | 77.8% | 99.0% of 195 | ≥50% support |
| Pfam | PF01119 | DNA_mis_repair — DNA mismatch repair protein, C-terminal domain | 173 / 248 | 69.8% | 96.1% of 180 | ≥50% support |
| Pfam | PF13589 | HATPase_c_3 — Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 160 / 248 | 64.5% | 88.9% of 180 | ≥50% support |
| GO | GO:0016887 Molecular Function | ATP hydrolysis activity | 194 / 248 | 78.2% | 99.5% of 195 | ≥50% support |
| GO | GO:0006298 Biological Process | mismatch repair | 193 / 248 | 77.8% | 99.0% of 195 | ≥50% support |
| GO | GO:0032300 Cellular Component | mismatch repair complex | 193 / 248 | 77.8% | 99.0% of 195 | ≥50% support |
| GO | GO:0032389 Cellular Component | MutLalpha complex | 193 / 248 | 77.8% | 99.0% of 195 | ≥50% support |
| GO | GO:0140664 Molecular Function | ATP-dependent DNA damage sensor activity | 193 / 248 | 77.8% | 99.0% of 195 | ≥50% support |
| GO | GO:0005524 Molecular Function | ATP binding | 180 / 248 | 72.6% | 92.3% of 195 | ≥50% support |
| GO | GO:0030983 Molecular Function | mismatched DNA binding | 179 / 248 | 72.2% | 91.8% of 195 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Desmophyllum pertusum | KAJ7380058.1 | KAJ7380058.1 | ATP-binding mismatch repair protein [Desmophyllum pertusum] | – | JBrowse |
| Desmophyllum pertusum | KAJ7380059.1 | KAJ7380059.1 | ATP-binding mismatch repair protein [Desmophyllum pertusum] | P54277 PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 | JBrowse |
