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This orthogroup contains 335 genes from 140 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 335 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45945 | REGULATOR OF G-PROTEIN SIGNALING LOCO | 271 / 335 | 80.9% | 98.9% of 274 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 273 / 335 | 81.5% | 94.5% of 289 | ≥80% support |
| GO | GO:0005886 Cellular Component | plasma membrane | 272 / 335 | 81.2% | 94.1% of 289 | ≥80% support |
| GO | GO:0005096 Molecular Function | GTPase activator activity | 271 / 335 | 80.9% | 93.8% of 289 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 271 / 335 | 80.9% | 93.8% of 289 | ≥80% support |
| GO | GO:0008277 Biological Process | regulation of G protein-coupled receptor signaling pathway | 271 / 335 | 80.9% | 93.8% of 289 | ≥80% support |
| Pfam | PF00615 | RGS — Regulator of G protein signaling domain | 233 / 335 | 69.6% | 82.3% of 283 | ≥50% support |
| Pfam | PF02196 | RBD — Raf-like Ras-binding domain | 207 / 335 | 61.8% | 73.1% of 283 | ≥50% support |
| Pfam | PF00595 | PDZ | 183 / 335 | 54.6% | 64.7% of 283 | ≥50% support |
| GO | GO:0007165 Biological Process | signal transduction | 237 / 335 | 70.8% | 82.0% of 289 | ≥50% support |
| GO | GO:0030695 Molecular Function | GTPase regulator activity | 208 / 335 | 62.1% | 72.0% of 289 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 206 / 335 | 61.5% | 71.3% of 289 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Eunicella cavolini | ENSLDHP00000045593.1 | XP_028390913.1 | regulator of G-protein signaling 12-like isoform X1 [Dendronephthya gigantea] | Q8CGE9 Regulator of G-protein signaling 12 OS=Mus musculus OX=10090 | JBrowse |
| Eunicella cavolini | ENSLDHP00000045606.1 | CAB3999278.1 | regulator of G- signaling 12-like isoform X1 [Paramuricea clavata] | Q9VCX1 Regulator of G-protein signaling loco OS=Drosophila melanoga | JBrowse |
| Eunicella cavolini | ENSLDHP00000045614.1 | CAB3999278.1 | regulator of G- signaling 12-like isoform X1 [Paramuricea clavata] | Q9VCX1 Regulator of G-protein signaling loco OS=Drosophila melanoga | JBrowse |
| Eunicella cavolini | ENSLDHP00000045625.1 | XP_028390915.1 | regulator of G-protein signaling 12-like isoform X2 [Dendronephthya gigantea] | Q8CGE9 Regulator of G-protein signaling 12 OS=Mus musculus OX=10090 | JBrowse |
