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This orthogroup contains 295 genes from 139 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 295 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| Pfam | PF12796 | Ank_2 — Ankyrin repeats (3 copies) | 226 / 295 | 76.6% | 88.3% of 256 | ≥50% support |
| Pfam | PF00008 | EGF | 206 / 295 | 69.8% | 80.5% of 256 | ≥50% support |
| Pfam | PF12661 | hEGF — Human growth factor-like EGF | 186 / 295 | 63.1% | 72.7% of 256 | ≥50% support |
| Pfam | PF00066 | Notch — LNR domain | 180 / 295 | 61.0% | 70.3% of 256 | ≥50% support |
| Pfam | PF07645 | EGF_CA — Calcium-binding EGF domain | 175 / 295 | 59.3% | 68.4% of 256 | ≥50% support |
| Pfam | PF07684 | NODP — NOTCH protein | 172 / 295 | 58.3% | 67.2% of 256 | ≥50% support |
| Pfam | PF06816 | NOD — NOTCH protein | 166 / 295 | 56.3% | 64.8% of 256 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 227 / 295 | 77.0% | 88.7% of 256 | ≥50% support |
| GO | GO:0005509 Molecular Function | calcium ion binding | 208 / 295 | 70.5% | 81.3% of 256 | ≥50% support |
| GO | GO:0007219 Biological Process | Notch signaling pathway | 201 / 295 | 68.1% | 78.5% of 256 | ≥50% support |
| GO | GO:0016020 Cellular Component | membrane | 197 / 295 | 66.8% | 77.0% of 256 | ≥50% support |
| GO | GO:0030154 Biological Process | cell differentiation | 197 / 295 | 66.8% | 77.0% of 256 | ≥50% support |
| GO | GO:0007275 Biological Process | multicellular organism development | 173 / 295 | 58.6% | 67.6% of 256 | ≥50% support |
| GO | GO:0050793 Biological Process | regulation of developmental process | 149 / 295 | 50.5% | 58.2% of 256 | ≥50% support |
| KEGG | K02599 | NOTCH1 — Endocrine resistance | 152 / 295 | 51.5% | 96.8% of 157 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Eunicella cavolini | ENSLDHP00000014735.1 | XP_028407580.1 | neurogenic locus notch homolog protein 1-like isoform X1 [Dendronephthya gigantea] | Q04721 Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX= | JBrowse |
| Eunicella cavolini | ENSLDHP00000014745.1 | XP_028407580.1 | neurogenic locus notch homolog protein 1-like isoform X1 [Dendronephthya gigantea] | Q04721 Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX= | JBrowse |
| Eunicella cavolini | ENSLDHP00000014754.1 | XP_028407580.1 | neurogenic locus notch homolog protein 1-like isoform X1 [Dendronephthya gigantea] | Q04721 Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX= | JBrowse |
