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This orthogroup contains 249 genes from 142 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 249 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR15749 | FANCONI-ASSOCIATED NUCLEASE 1 | 220 / 249 | 88.4% | 99.6% of 221 | ≥80% support |
| GO | GO:0004518 Molecular Function | nuclease activity | 220 / 249 | 88.4% | 99.6% of 221 | ≥80% support |
| GO | GO:0036297 Biological Process | interstrand cross-link repair | 220 / 249 | 88.4% | 99.6% of 221 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 217 / 249 | 87.2% | 98.2% of 221 | ≥80% support |
| GO | GO:0008409 Molecular Function | 5'-3' exonuclease activity | 217 / 249 | 87.2% | 98.2% of 221 | ≥80% support |
| GO | GO:0017108 Molecular Function | 5'-flap endonuclease activity | 217 / 249 | 87.2% | 98.2% of 221 | ≥80% support |
| GO | GO:0070336 Molecular Function | flap-structured DNA binding | 217 / 249 | 87.2% | 98.2% of 221 | ≥80% support |
| Pfam | PF21170 | FAN1_TPR — Fanconi-associated nuclease 1, TPR domain | 177 / 249 | 71.1% | 82.7% of 214 | ≥50% support |
| Pfam | PF08774 | VRR_NUC — VRR-NUC domain | 170 / 249 | 68.3% | 79.4% of 214 | ≥50% support |
| Pfam | PF21315 | FAN1_HTH — FAN1, HTH domain | 166 / 249 | 66.7% | 77.6% of 214 | ≥50% support |
| GO | GO:0016788 Molecular Function | hydrolase activity, acting on ester bonds | 170 / 249 | 68.3% | 76.9% of 221 | ≥50% support |
| GO | GO:0003676 Molecular Function | nucleic acid binding | 159 / 249 | 63.9% | 72.0% of 221 | ≥50% support |
| KEGG | K15363 | FAN1, MTMR15 — DNA repair and recombination proteins | 134 / 249 | 53.8% | 97.8% of 137 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Eunicella cavolini | ENSLDHP00000040356.1 | XP_046860759.1 | fanconi-associated nuclease 1-like isoform X1 [Xenia sp. Carnegie-2017] | Q1LWH4 Fanconi-associated nuclease 1 OS=Danio rerio OX=7955 GN=fan1 | JBrowse |
| Eunicella cavolini | ENSLDHP00000040371.1 | XP_046860764.1 | fanconi-associated nuclease 1-like isoform X2 [Xenia sp. Carnegie-2017] | Q1LWH4 Fanconi-associated nuclease 1 OS=Danio rerio OX=7955 GN=fan1 | JBrowse |
| Eunicella cavolini | ENSLDHP00000040386.1 | XP_046860759.1 | fanconi-associated nuclease 1-like isoform X1 [Xenia sp. Carnegie-2017] | Q1LWH4 Fanconi-associated nuclease 1 OS=Danio rerio OX=7955 GN=fan1 | JBrowse |
