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This orthogroup contains 228 genes from 136 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 228 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR21092 | NICASTRIN | 197 / 228 | 86.4% | 99.5% of 198 | ≥80% support |
| Pfam | PF05450 | Nicastrin | 187 / 228 | 82.0% | 94.9% of 197 | ≥80% support |
| GO | GO:0005887 Cellular Component | plasma membrane | 197 / 228 | 86.4% | 99.5% of 198 | ≥80% support |
| GO | GO:0016020 Cellular Component | membrane | 197 / 228 | 86.4% | 99.5% of 198 | ≥80% support |
| GO | GO:0016485 Biological Process | protein processing | 197 / 228 | 86.4% | 99.5% of 198 | ≥80% support |
| Pfam | PF18266 | Ncstrn_small — Nicastrin small lobe | 181 / 228 | 79.4% | 91.9% of 197 | ≥50% support |
| KEGG | K06171 | NCSTN — Alzheimer disease | 160 / 228 | 70.2% | 99.4% of 161 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Eunicella cavolini | ENSLDHP00000035633.1 | CAB3995124.1 | Nicastrin [Paramuricea clavata] | Q92542 Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2 | JBrowse |
| Eunicella cavolini | ENSLDHP00000035649.1 | CAB3995124.1 | Nicastrin [Paramuricea clavata] | Q92542 Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2 | JBrowse |
