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This orthogroup contains 231 genes from 137 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 231 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR13703 | SMAD | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0000981 Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0071144 Cellular Component | heteromeric SMAD protein complex | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0070411 Molecular Function | I-SMAD binding | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0060395 Biological Process | SMAD protein signal transduction | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0030509 Biological Process | BMP signaling pathway | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0030154 Biological Process | cell differentiation | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0009653 Biological Process | anatomical structure morphogenesis | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0007179 Biological Process | transforming growth factor beta receptor signaling pathway | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0006357 Biological Process | regulation of transcription by RNA polymerase II | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0006355 Biological Process | regulation of DNA-templated transcription | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| GO | GO:0000978 Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 186 / 231 | 80.5% | 100.0% of 186 | ≥80% support |
| Pfam | PF03166 | MH2 | 167 / 231 | 72.3% | 89.8% of 186 | ≥50% support |
| Pfam | PF03165 | MH1 | 157 / 231 | 68.0% | 84.4% of 186 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 167 / 231 | 72.3% | 89.8% of 186 | ≥50% support |
| GO | GO:0005667 Cellular Component | transcription regulator complex | 158 / 231 | 68.4% | 85.0% of 186 | ≥50% support |
| KEGG | K04501 | SMAD4 — AGE-RAGE signaling pathway in diabetic complications | 146 / 231 | 63.2% | 100.0% of 146 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Hemicorallium imperiale | evm.model.Chr20.471 | XP_028402521.1 | mothers against decapentaplegic homolog 4-like [Dendronephthya gigantea] | Q13485 Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX | JBrowse |
