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Support counts the member genes carrying the term. % of genes is that count over all 11 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45754 | METHYLENETETRAHYDROFOLATE REDUCTASE | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| Pfam | PF02219 | MTHFR — Methylenetetrahydrofolate reductase | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0004489 Molecular Function | methylenetetrahydrofolate reductase (NAD(P)H) activity | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0006555 Biological Process | methionine metabolic process | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0009086 Biological Process | methionine biosynthetic process | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0035999 Biological Process | tetrahydrofolate interconversion | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| GO | GO:0071949 Molecular Function | FAD binding | 10 / 11 | 90.9% | 100.0% of 10 | ≥80% support |
| KEGG | K00297 | metF, MTHFR — One carbon pool by folate | 8 / 11 | 72.7% | 100.0% of 8 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Hydra oligactis | HOLI00002.G17461 | MBC7696576.1 | methylenetetrahydrofolate reductase [NAD(P)H] [Burkholderiales bacterium] | O67422 5,10-methylenetetrahydrofolate reductase OS=Aquifex aeolicus | JBrowse |
| Hydra oligactis | HOLI00059.G25589 | WP_105261334.1 | methylenetetrahydrofolate reductase [NAD(P)H] [Rhodoferax sp. TS-BS-61-7] | O67422 5,10-methylenetetrahydrofolate reductase OS=Aquifex aeolicus | JBrowse |
| Hydra oligactis | HOLI01087.G37578 | WP_094291648.1 | methylenetetrahydrofolate reductase [NAD(P)H] [Acidovorax kalamii] | Q9JZQ3 5,10-methylenetetrahydrofolate reductase OS=Neisseria mening | JBrowse |
