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This orthogroup contains 247 genes from 135 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 247 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR31441 | FOLLICULIN FAMILY MEMBER | 223 / 247 | 90.3% | 100.0% of 223 | ≥80% support |
| GO | GO:0005096 Molecular Function | GTPase activator activity | 223 / 247 | 90.3% | 100.0% of 223 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 223 / 247 | 90.3% | 100.0% of 223 | ≥80% support |
| GO | GO:1904263 Biological Process | positive regulation of TORC1 signaling | 223 / 247 | 90.3% | 100.0% of 223 | ≥80% support |
| GO | GO:0000122 Biological Process | negative regulation of transcription by RNA polymerase II | 222 / 247 | 89.9% | 99.6% of 223 | ≥80% support |
| GO | GO:0030511 Biological Process | positive regulation of transforming growth factor beta receptor signaling pathway | 222 / 247 | 89.9% | 99.6% of 223 | ≥80% support |
| Pfam | PF16692 | Folliculin_C — Folliculin C-terminal domain | 196 / 247 | 79.4% | 88.7% of 221 | ≥50% support |
| Pfam | PF11704 | Folliculin — Vesicle coat protein involved in Golgi to plasma membrane transport | 195 / 247 | 79.0% | 88.2% of 221 | ≥50% support |
| KEGG | K09594 | FLCN, BHD — Renal cell carcinoma | 151 / 247 | 61.1% | 98.7% of 153 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Lophelia pertusa | OS493_002231-T1 | KAJ7375458.1 | hypothetical protein OS493_002231 [Desmophyllum pertusum] | Q3B7L5 Folliculin OS=Bos taurus OX=9913 GN=FLCN PE=2 SV=1 | JBrowse |
