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This orthogroup contains 234 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 234 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR11540 | MALATE AND LACTATE DEHYDROGENASE | 209 / 234 | 89.3% | 100.0% of 209 | ≥80% support |
| Pfam | PF00056 | Ldh_1_N — lactate/malate dehydrogenase, NAD binding domain | 196 / 234 | 83.8% | 93.3% of 210 | ≥80% support |
| Pfam | PF02866 | Ldh_1_C — lactate/malate dehydrogenase, alpha/beta C-terminal domain | 191 / 234 | 81.6% | 91.0% of 210 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 209 / 234 | 89.3% | 99.5% of 210 | ≥80% support |
| GO | GO:0030060 Molecular Function | L-malate dehydrogenase (NAD+) activity | 209 / 234 | 89.3% | 99.5% of 210 | ≥80% support |
| GO | GO:0006099 Biological Process | tricarboxylic acid cycle | 203 / 234 | 86.8% | 96.7% of 210 | ≥80% support |
| GO | GO:0005739 Cellular Component | mitochondrion | 201 / 234 | 85.9% | 95.7% of 210 | ≥80% support |
| GO | GO:0016491 Molecular Function | oxidoreductase activity | 196 / 234 | 83.8% | 93.3% of 210 | ≥80% support |
| GO | GO:0003824 Molecular Function | catalytic activity | 192 / 234 | 82.1% | 91.4% of 210 | ≥80% support |
| GO | GO:0016616 Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 192 / 234 | 82.1% | 91.4% of 210 | ≥80% support |
| GO | GO:0006108 Biological Process | malate metabolic process | 164 / 234 | 70.1% | 78.1% of 210 | ≥50% support |
| GO | GO:0016615 Molecular Function | malate dehydrogenase activity | 164 / 234 | 70.1% | 78.1% of 210 | ≥50% support |
| GO | GO:0019752 Biological Process | carboxylic acid metabolic process | 147 / 234 | 62.8% | 70.0% of 210 | ≥50% support |
| KEGG | K00026 | MDH2 — Cysteine and methionine metabolism | 156 / 234 | 66.7% | 98.7% of 158 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Lophelia pertusa | OS493_009316-T1 | KAJ7373988.1 | malate DEHYDROGENASE, NAD-dependent [Desmophyllum pertusum] | Q5NVR2 Malate dehydrogenase, mitochondrial OS=Pongo abelii OX=9601 | JBrowse |
