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This orthogroup contains 236 genes from 141 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 236 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR46803 | E3 UBIQUITIN-PROTEIN LIGASE CHIP | 207 / 236 | 87.7% | 98.6% of 210 | ≥80% support |
| Pfam | PF04564 | U-box | 196 / 236 | 83.1% | 93.3% of 210 | ≥80% support |
| Pfam | PF18391 | CHIP_TPR_N — CHIP N-terminal tetratricopeptide repeat domain | 195 / 236 | 82.6% | 92.9% of 210 | ≥80% support |
| GO | GO:0000209 Biological Process | protein polyubiquitination | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0006515 Biological Process | protein quality control for misfolded or incompletely synthesized proteins | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0043161 Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0045862 Biological Process | positive regulation of proteolysis | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0051087 Molecular Function | protein-folding chaperone binding | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0061630 Molecular Function | ubiquitin protein ligase activity | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0071218 Biological Process | cellular response to misfolded protein | 207 / 236 | 87.7% | 98.1% of 211 | ≥80% support |
| GO | GO:0004842 Molecular Function | ubiquitin-protein transferase activity | 196 / 236 | 83.1% | 92.9% of 211 | ≥80% support |
| GO | GO:0005515 Molecular Function | protein binding | 196 / 236 | 83.1% | 92.9% of 211 | ≥80% support |
| GO | GO:0016567 Biological Process | protein ubiquitination | 196 / 236 | 83.1% | 92.9% of 211 | ≥80% support |
| Pfam | PF12895 | ANAPC3 — Anaphase-promoting complex, cyclosome, subunit 3 | 158 / 236 | 67.0% | 75.2% of 210 | ≥50% support |
| KEGG | K09561 | STUB1, CHIP — Ubiquitin system | 174 / 236 | 73.7% | 98.9% of 176 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Millepora alcicornis | ENSCIQP00000007372.1 | XP_002169066.2 | E3 ubiquitin-protein ligase CHIP [Hydra vulgaris] | Q5ZHY5 E3 ubiquitin-protein ligase CHIP OS=Gallus gallus OX=9031 GN | JBrowse |
| Millepora alcicornis | ENSCIQP00000007384.1 | XP_002169066.2 | E3 ubiquitin-protein ligase CHIP [Hydra vulgaris] | Q9WUD1 E3 ubiquitin-protein ligase CHIP OS=Mus musculus OX=10090 GN | JBrowse |
