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This orthogroup contains 294 genes from 145 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 294 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR14025 | FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER | 216 / 294 | 73.5% | 92.7% of 233 | ≥50% support |
| Pfam | PF00271 | Helicase_C — Helicase conserved C-terminal domain | 191 / 294 | 65.0% | 78.9% of 242 | ≥50% support |
| Pfam | PF16783 | FANCM-MHF_bd — FANCM to MHF binding domain | 170 / 294 | 57.8% | 70.3% of 242 | ≥50% support |
| Pfam | PF02732 | ERCC4 | 156 / 294 | 53.1% | 64.5% of 242 | ≥50% support |
| GO | GO:0009378 Molecular Function | four-way junction helicase activity | 214 / 294 | 72.8% | 87.7% of 244 | ≥50% support |
| GO | GO:0043138 Molecular Function | 3'-5' DNA helicase activity | 214 / 294 | 72.8% | 87.7% of 244 | ≥50% support |
| GO | GO:0000400 Molecular Function | four-way junction DNA binding | 213 / 294 | 72.5% | 87.3% of 244 | ≥50% support |
| GO | GO:0036297 Biological Process | interstrand cross-link repair | 213 / 294 | 72.5% | 87.3% of 244 | ≥50% support |
| GO | GO:0045003 Biological Process | double-strand break repair via synthesis-dependent strand annealing | 213 / 294 | 72.5% | 87.3% of 244 | ≥50% support |
| GO | GO:0005524 Molecular Function | ATP binding | 202 / 294 | 68.7% | 82.8% of 244 | ≥50% support |
| GO | GO:0006281 Biological Process | DNA repair | 193 / 294 | 65.7% | 79.1% of 244 | ≥50% support |
| GO | GO:0003677 Molecular Function | DNA binding | 182 / 294 | 61.9% | 74.6% of 244 | ≥50% support |
| GO | GO:0004518 Molecular Function | nuclease activity | 158 / 294 | 53.7% | 64.8% of 244 | ≥50% support |
| KEGG | K10896 | FANCM — DNA repair and recombination proteins | 159 / 294 | 54.1% | 97.0% of 164 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Montipora capitata | g2548.t1 | XP_044162822.1 | Fanconi anemia group M protein homolog [Acropora millepora] | Q8BGE5 Fanconi anemia group M protein homolog OS=Mus musculus OX=10 | JBrowse |
