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This orthogroup contains 287 genes from 140 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 287 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR13451 | CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81 | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0000712 Biological Process | resolution of meiotic recombination intermediates | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0000727 Biological Process | double-strand break repair via break-induced replication | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0006302 Biological Process | double-strand break repair | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0006308 Biological Process | DNA catabolic process | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0008821 Molecular Function | crossover junction DNA endonuclease activity | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0031573 Biological Process | mitotic intra-S DNA damage checkpoint signaling | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0048257 Molecular Function | 3'-flap endonuclease activity | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| GO | GO:0048476 Cellular Component | Holliday junction resolvase complex | 232 / 287 | 80.8% | 100.0% of 232 | ≥80% support |
| Pfam | PF02732 | ERCC4 | 195 / 287 | 67.9% | 85.2% of 229 | ≥50% support |
| Pfam | PF21136 | MUS81-like_WH — Crossover junction endonuclease MUS81-like, winged helix domain | 190 / 287 | 66.2% | 83.0% of 229 | ≥50% support |
| Pfam | PF21292 | EME1-MUS81_C — EME1/MUS81, C-terminal | 165 / 287 | 57.5% | 72.1% of 229 | ≥50% support |
| GO | GO:0003677 Molecular Function | DNA binding | 195 / 287 | 67.9% | 84.1% of 232 | ≥50% support |
| GO | GO:0004518 Molecular Function | nuclease activity | 195 / 287 | 67.9% | 84.1% of 232 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Montipora capitata | g2159.t1 | KAJ7360130.1 | Crossover junction endonuclease mus81 [Desmophyllum pertusum] | Q640B4 Structure-specific endonuclease subunit MUS81 OS=Xenopus tro | JBrowse |
