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This orthogroup contains 123 genes from 110 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 123 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR16318 | GAMMA-SECRETASE SUBUNIT PEN-2 | 103 / 123 | 83.7% | 100.0% of 103 | ≥80% support |
| Pfam | PF10251 | PEN-2 — Presenilin enhancer-2 subunit of gamma secretase | 114 / 123 | 92.7% | 100.0% of 114 | ≥80% support |
| GO | GO:0070765 Cellular Component | gamma-secretase complex | 103 / 123 | 83.7% | 100.0% of 103 | ≥80% support |
| KEGG | K06170 | PSENEN, PEN2 — Alzheimer disease | 95 / 123 | 77.2% | 99.0% of 96 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Montipora efflorescens | ENSTIFP00000020370.1 | XP_020609652.1 | gamma-secretase subunit PEN-2-like [Orbicella faveolata] | Q6QI68 Gamma-secretase subunit PEN-2 OS=Rattus norvegicus OX=10116 | JBrowse |
