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This orthogroup contains 335 genes from 139 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 335 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45833 | METHIONINE SYNTHASE | 301 / 335 | 89.9% | 100.0% of 301 | ≥80% support |
| GO | GO:0008705 Molecular Function | methionine synthase activity | 304 / 335 | 90.8% | 100.0% of 304 | ≥80% support |
| GO | GO:0009086 Biological Process | methionine biosynthetic process | 304 / 335 | 90.8% | 100.0% of 304 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 301 / 335 | 89.9% | 99.0% of 304 | ≥80% support |
| GO | GO:0046653 Biological Process | tetrahydrofolate metabolic process | 299 / 335 | 89.3% | 98.4% of 304 | ≥80% support |
| GO | GO:0050667 Biological Process | homocysteine metabolic process | 299 / 335 | 89.3% | 98.4% of 304 | ≥80% support |
| Pfam | PF02965 | Met_synt_B12 — Vitamin B12 dependent methionine synthase, activation domain | 257 / 335 | 76.7% | 84.5% of 304 | ≥50% support |
| Pfam | PF02574 | S-methyl_trans — Homocysteine S-methyltransferase | 232 / 335 | 69.3% | 76.3% of 304 | ≥50% support |
| Pfam | PF02310 | B12-binding — B12 binding domain | 231 / 335 | 69.0% | 76.0% of 304 | ≥50% support |
| Pfam | PF00809 | Pterin_bind — Pterin binding enzyme | 226 / 335 | 67.5% | 74.3% of 304 | ≥50% support |
| Pfam | PF02607 | B12-binding_2 — B12 binding domain | 223 / 335 | 66.6% | 73.4% of 304 | ≥50% support |
| GO | GO:0031419 Molecular Function | cobalamin binding | 241 / 335 | 71.9% | 79.3% of 304 | ≥50% support |
| GO | GO:0046872 Molecular Function | metal ion binding | 238 / 335 | 71.0% | 78.3% of 304 | ≥50% support |
| GO | GO:0044237 Biological Process | obsolete cellular metabolic process | 231 / 335 | 69.0% | 76.0% of 304 | ≥50% support |
| GO | GO:0042558 Biological Process | pteridine-containing compound metabolic process | 226 / 335 | 67.5% | 74.3% of 304 | ≥50% support |
| GO | GO:0008270 Molecular Function | zinc ion binding | 210 / 335 | 62.7% | 69.1% of 304 | ≥50% support |
| KEGG | K00548 | metH, MTR — Cobalamin transport and metabolism | 230 / 335 | 68.7% | 99.6% of 231 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Mastigias papua | BRAKERKYLP00000017781.1 | XP_048585706.1 | methionine synthase [Nematostella vectensis] | Q4JIJ3 Methionine synthase OS=Bos taurus OX=9913 GN=MTR PE=2 SV=1 | JBrowse |
