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This orthogroup contains 320 genes from 140 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 320 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR22884 | SET DOMAIN PROTEINS | 274 / 320 | 85.6% | 98.6% of 278 | ≥80% support |
| Pfam | PF00855 | PWWP | 251 / 320 | 78.4% | 89.3% of 281 | ≥50% support |
| Pfam | PF00856 | SET | 245 / 320 | 76.6% | 87.2% of 281 | ≥50% support |
| Pfam | PF17907 | AWS | 244 / 320 | 76.3% | 86.8% of 281 | ≥50% support |
| Pfam | PF17982 | C5HCH — NSD Cys-His rich domain | 166 / 320 | 51.9% | 59.1% of 281 | ≥50% support |
| GO | GO:0005634 Cellular Component | nucleus | 249 / 320 | 77.8% | 95.8% of 260 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 247 / 320 | 77.2% | 95.0% of 260 | ≥50% support |
| GO | GO:0042054 Molecular Function | histone methyltransferase activity | 244 / 320 | 76.3% | 93.9% of 260 | ≥50% support |
| KEGG | K11424 | WHSC1, MMSET, NSD2 — Chromosome and associated proteins | 209 / 320 | 65.3% | 98.6% of 212 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Mastigias papua | BRAKERKYLP00000012306.1 | XP_027041944.1 | histone-lysine N-methyltransferase NSD2-like isoform X1 [Pocillopora damicornis] | O96028 Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9 | JBrowse |
| Mastigias papua | BRAKERKYLP00000012409.1 | XP_031551003.1 | histone-lysine N-methyltransferase NSD2-like isoform X2 [Actinia tenebrosa] | O96028 Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9 | JBrowse |
