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This orthogroup contains 225 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 225 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR11630 | DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER | 193 / 225 | 85.8% | 98.5% of 196 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 201 / 225 | 89.3% | 99.5% of 202 | ≥80% support |
| GO | GO:0003677 Molecular Function | DNA binding | 200 / 225 | 88.9% | 99.0% of 202 | ≥80% support |
| GO | GO:0042555 Cellular Component | MCM complex | 200 / 225 | 88.9% | 99.0% of 202 | ≥80% support |
| GO | GO:0005524 Molecular Function | ATP binding | 200 / 225 | 88.9% | 99.0% of 202 | ≥80% support |
| GO | GO:0032508 Biological Process | DNA duplex unwinding | 194 / 225 | 86.2% | 96.0% of 202 | ≥80% support |
| GO | GO:0017116 Molecular Function | single-stranded DNA helicase activity | 193 / 225 | 85.8% | 95.5% of 202 | ≥80% support |
| GO | GO:0003697 Molecular Function | single-stranded DNA binding | 193 / 225 | 85.8% | 95.5% of 202 | ≥80% support |
| GO | GO:0006268 Biological Process | DNA unwinding involved in DNA replication | 192 / 225 | 85.3% | 95.1% of 202 | ≥80% support |
| GO | GO:0043138 Molecular Function | 3'-5' DNA helicase activity | 192 / 225 | 85.3% | 95.1% of 202 | ≥80% support |
| GO | GO:1902975 Biological Process | mitotic DNA replication initiation | 192 / 225 | 85.3% | 95.1% of 202 | ≥80% support |
| GO | GO:0000727 Biological Process | double-strand break repair via break-induced replication | 192 / 225 | 85.3% | 95.1% of 202 | ≥80% support |
| GO | GO:0006270 Biological Process | DNA replication initiation | 188 / 225 | 83.6% | 93.1% of 202 | ≥80% support |
| GO | GO:1905775 Biological Process | obsolete negative regulation of DNA helicase activity | 188 / 225 | 83.6% | 93.1% of 202 | ≥80% support |
| Pfam | PF00493 | MCM | 179 / 225 | 79.6% | 87.8% of 204 | ≥50% support |
| Pfam | PF14551 | MCM_N — MCM N-terminal domain | 179 / 225 | 79.6% | 87.8% of 204 | ≥50% support |
| Pfam | PF17207 | MCM_OB — MCM OB domain | 178 / 225 | 79.1% | 87.3% of 204 | ≥50% support |
| Pfam | PF17855 | MCM_lid — MCM AAA-lid domain | 173 / 225 | 76.9% | 84.8% of 204 | ≥50% support |
| Pfam | PF12619 | MCM2_N — Mini-chromosome maintenance protein 2 | 166 / 225 | 73.8% | 81.4% of 204 | ≥50% support |
| GO | GO:0006260 Biological Process | DNA replication | 156 / 225 | 69.3% | 77.2% of 202 | ≥50% support |
| KEGG | K02540 | MCM2 — Chromosome and associated proteins | 170 / 225 | 75.6% | 98.8% of 172 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Mastigias papua | BRAKERKYLP00000015990.1 | XP_047122833.1 | DNA replication licensing factor mcm2-like [Hydra vulgaris] | P55861 DNA replication licensing factor mcm2 OS=Xenopus laevis OX=8 | JBrowse |
