Gene Family

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Member genes
2,575
Species
145
Sequences
2,575
Best annotation support
90.7%

Consensus functional annotation

No term is shared by every member gene — the best-supported term below covers 90.7% of the 2,575 members.

Support counts the member genes carrying the term. % of genes is that count over all 2,575 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.

Source Term Name / description Support % of genes % annotated Consistency
PfamPF00010HLH — Helix-loop-helix DNA-binding domain2335 / 2,57590.7%99.9%
of 2,337
≥80% support
GOGO:0046983
Molecular Function
protein dimerization activity2337 / 2,57590.8%100.0%
of 2,338
≥80% support
GOGO:0000981
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific2321 / 2,57590.1%99.3%
of 2,338
≥80% support
GOGO:0006357
Biological Process
regulation of transcription by RNA polymerase II2156 / 2,57583.7%92.2%
of 2,338
≥80% support
PANTHERPTHR23349BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST1851 / 2,57571.9%79.7%
of 2,324
≥50% support
GOGO:0000977
Molecular Function
RNA polymerase II transcription regulatory region sequence-specific DNA binding1851 / 2,57571.9%79.2%
of 2,338
≥50% support
GOGO:0032502
Biological Process
developmental process1851 / 2,57571.9%79.2%
of 2,338
≥50% support
📊 Total members in OG0000221: 19 (filtered to NVECT · show all species)
Show: genes per page

Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.

Species Gene ID Top NCBI-NR hit
(accession)
Top NCBI-NR hit description
(source organism)
Top UniProt hit
(Swiss-Prot)
Genome browser
Nematostella vectensisXP_001628329.2XP_001628329.2transcription factor atoh8 [Nematostella vectensis]Q96SQ7
Transcription factor ATOH8 OS=Homo sapiens OX=9606 GN=ATOH8
JBrowse
Nematostella vectensisXP_001632876.2XP_001632876.2heart- and neural crest derivatives-expressed protein 2 [Nematostella vectensis]P57102
Heart- and neural crest derivatives-expressed protein 2 OS=D
JBrowse
Nematostella vectensisXP_001634988.2XP_001634988.2transcription factor 15 [Nematostella vectensis]Q6QHK4
Factor in the germline alpha OS=Homo sapiens OX=9606 GN=FIGL
JBrowse
Nematostella vectensisXP_032218720.1XP_032218720.1T-cell acute lymphocytic leukemia protein 1 [Nematostella vectensis]Q90YI8
T-cell acute lymphocytic leukemia protein 1 OS=Takifugu rubr
JBrowse
Nematostella vectensisXP_032218908.2XP_032218908.2T-cell acute lymphocytic leukemia protein 1 homolog [Nematostella vectensis]O93507
T-cell acute lymphocytic leukemia protein 1 homolog OS=Danio
JBrowse
Nematostella vectensisXP_032225258.1XP_032225258.1achaete-scute homolog 4 [Nematostella vectensis]Q6XD76
Achaete-scute homolog 4 OS=Homo sapiens OX=9606 GN=ASCL4 PE=
JBrowse
Nematostella vectensisXP_032226875.2XP_032226875.2achaete-scute homolog 2 [Nematostella vectensis]Q90259
Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE
JBrowse
Nematostella vectensisXP_032237760.2XP_032237760.2helix-loop-helix protein 2 isoform X3 [Nematostella vectensis]Q90259
Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE
JBrowse
Nematostella vectensisXP_032237799.1XP_032237799.1heart- and neural crest derivatives-expressed protein 1 [Nematostella vectensis]Q64279
Heart- and neural crest derivatives-expressed protein 1 OS=M
JBrowse
Nematostella vectensisXP_032240324.1XP_032240324.1twist-related protein [Nematostella vectensis]P13903
Twist-related protein OS=Xenopus laevis OX=8355 GN=twist1 PE
JBrowse
Nematostella vectensisXP_032240365.1XP_032240365.1transcription factor 15 [Nematostella vectensis]P79782
Transcription factor 15 OS=Gallus gallus OX=9031 GN=TCF15 PE
JBrowse
Nematostella vectensisXP_032240383.2XP_032240383.2uncharacterized protein LOC116619576 [Nematostella vectensis]–JBrowse
Nematostella vectensisXP_032241075.1XP_032241075.1transcription factor Atoh1 [Nematostella vectensis]P48985
Transcription factor Atoh1 OS=Mus musculus OX=10090 GN=Atoh1
JBrowse
Nematostella vectensisXP_032241076.1XP_032241076.1transcription factor Atoh1 [Nematostella vectensis]Q60430
Neurogenic differentiation factor 1 OS=Mesocricetus auratus
JBrowse
Nematostella vectensisXP_032241387.2XP_032241387.2pancreas transcription factor 1 subunit alpha [Nematostella vectensis]Q7ZSX3
Pancreas transcription factor 1 subunit alpha OS=Danio rerio
JBrowse
Nematostella vectensisXP_048578975.1XP_048578975.1helix-loop-helix protein 2 isoform X1 [Nematostella vectensis]Q90259
Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE
JBrowse
Nematostella vectensisXP_048578976.1XP_032237760.2helix-loop-helix protein 2 isoform X3 [Nematostella vectensis]Q90259
Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE
JBrowse
Nematostella vectensisXP_048580329.1XP_048580329.1pancreas transcription factor 1 subunit alpha-like [Nematostella vectensis]Q7ZSX3
Pancreas transcription factor 1 subunit alpha OS=Danio rerio
JBrowse
Nematostella vectensisXP_048587899.1XP_048587899.1T-cell acute lymphocytic leukemia protein 1-like [Nematostella vectensis]Q90YI8
T-cell acute lymphocytic leukemia protein 1 OS=Takifugu rubr
JBrowse
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