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This orthogroup contains 265 genes from 145 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 265 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR16777 | PROTEIN ECT2 | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 239 / 265 | 90.2% | 100.0% of 239 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 239 / 265 | 90.2% | 100.0% of 239 | ≥80% support |
| GO | GO:0005085 Molecular Function | guanyl-nucleotide exchange factor activity | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:2000431 Biological Process | regulation of cytokinesis, actomyosin contractile ring assembly | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0090630 Biological Process | activation of GTPase activity | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0043547 Biological Process | positive regulation of GTPase activity | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0007399 Biological Process | nervous system development | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0005938 Cellular Component | cell cortex | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0005096 Molecular Function | GTPase activator activity | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| GO | GO:0000281 Biological Process | mitotic cytokinesis | 238 / 265 | 89.8% | 99.6% of 239 | ≥80% support |
| Pfam | PF00621 | RhoGEF | 209 / 265 | 78.9% | 89.7% of 233 | ≥50% support |
| Pfam | PF21242 | ECT2_PH — ECT2, PH domain | 204 / 265 | 77.0% | 87.6% of 233 | ≥50% support |
| Pfam | PF12738 | PTCB-BRCT — twin BRCT domain | 187 / 265 | 70.6% | 80.3% of 233 | ≥50% support |
| Pfam | PF21243 | ECT2_BRCT0 — ECT2, BRCT0 domain | 153 / 265 | 57.7% | 65.7% of 233 | ≥50% support |
| GO | GO:0035556 Biological Process | intracellular signal transduction | 191 / 265 | 72.1% | 79.9% of 239 | ≥50% support |
| KEGG | K20704 | ECT2, ARHGEF31 — Membrane trafficking | 178 / 265 | 67.2% | 99.4% of 179 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Nematostella vectensis | XP_032231100.2 | XP_032231100.2 | protein ECT2 [Nematostella vectensis] | Q9H8V3 Protein ECT2 OS=Homo sapiens OX=9606 GN=ECT2 PE=1 SV=4 | JBrowse |
