Diadumene leucolena is a small, pale sea anemone (family Diadumenidae) found in rocky intertidal and subtidal habitats of the North American Atlantic coast, reproducing asexually by spontaneous transverse fission (pedal laceration) enabling rapid colonization of bare substrates. The species native versus introduced status varies by locality, and it contributes to research into diadumenid systematics and invasion ecology. Research on this species advances understanding of the molecular basis of asexual reproduction and range expansion in marine invertebrates. Genomic data have been generated for this species and are available in public databases, enabling comparative studies of cnidarian evolution and ecology.