Diploria labyrinthiformis, the grooved brain coral (family Mussidae), is a massive dome-forming scleractinian coral widespread on Caribbean reefs, characterized by sinuous valleys and ridges resembling brain folds with large polyps extending along shared valleys. The species is one of the most prominent reef-builders in the Caribbean and is notable for its long lifespan, with some colonies estimated to be over 500 years old. It is considered Least Concern by the IUCN, though it remains vulnerable to bleaching, disease, and storm damage. Genomic data have been generated for this species and are available in public databases, enabling comparative studies of cnidarian evolution and ecology.